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Study on the genotoxicity of the polycyclic aromatic hidrocarbon (PAH) benzo[a]pyrene in the food chain: prey-predator interaction

Grant number: 07/01012-1
Support type:Regular Research Grants
Duration: June 01, 2007 - May 31, 2009
Field of knowledge:Physical Sciences and Mathematics - Oceanography - Biological Oceanography
Principal researcher:Phan van Ngan
Grantee:Phan van Ngan
Home Institution: Instituto Oceanográfico (IO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The Policyclyc aromatic hydrocarbons (PAHs) are organic pollutants usually found in coastal environments and the marine organisms can be suitable indicators of these contaminants in ecosystems. The PAHs biotransformation performed by different animals invertebrates and vertebrates, yields reactive oxygen substances (ROS), which are responsible for genotoxicity, may be produced through the trophic chain contamination. At this project, the Benzo[a]pyrene genotoxicity will be experimentally assessed through the prey-predator relationship, in which seabob shrimp Xiphopenaeus kroyeri 24h exposed to different benzo[a]pyrene concentrations will be fed by fat snook fish Centropomus parallelus, for 15 days. The rate of contamination will be investigated through the benzo[a]pyrene and bile metabolites concentrations of the muscle and bile of X. kroyeri and C. parallels, respectively. The genotoxicity degree will be determined by the Comet Assay, micronuclei and nuclear abnormality of cells from hemolymph and blood of X. kroyeri and C. parallelus, respectively. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, ARTHUR JOSE; ALVES SANTOS, THAIS CRUZ; GOMES, VICENTE; BICEGO, MARCIA CARUSO; RIZZATTI DE ALBERGARIA BARBOSA, ANA CECILIA; CAMPOS ROCHA PASSOS, MARIA JOSE DE ARRUDA; HASUE, FABIO MATSU; NGAN, PHAN VAN. Assessment of trophic transfer of benzo(a)pyrene genotoxicity from the post-larval pink shrimp F. brasiliensis to the juvenile Florida pompano T. carolinus. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 34, n. 3, p. 969-976, . (07/01012-1, 06/03925-1)
DA SILVA ROCHA, ARTHUR JOSE; GOMES, VICENTE; CAMPOS ROCHA PASSOS, MARIA JOSE DE ARRUDA; HASUE, FABIO MATSU; ALVES SANTOS, THAIS CRUZ; BICEGO, MARCIA CARUSO; TANIGUCHI, SATIE; NGAN, PHAN VAN. EROD activity and genotoxicity in the seabob shrimp Xiphopenaeus kroyeri exposed to benzo[a]pyrene (BaP) concentrations. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 34, n. 3, p. 995-1003, . (07/01012-1, 06/03925-1)

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