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Thyroid evaluation in patients with hepatitis C infection: correlation to CTLA-4 gene polymorphisms

Grant number: 06/06080-2
Support Opportunities:Regular Research Grants
Duration: February 01, 2007 - January 31, 2010
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Suemi Marui
Grantee:Suemi Marui
Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Hepatitis caused by virus C (HCV) correlates to thyroid diseases not only because of interferon-alpha (IFNa) treatment, but also due to common association to thyroid autoimmunity. Finding elevated incidence of thyroid peroxidase antibodies in patients with HCV denotes a genetic susceptibility to autoimmune disorder. CTLA-4 gene is enrolled in preservation of immune tolerance and polymorphisms in this gene are known to be associated to thyroid autoimmune disease, especially Graves’ disease. Thyrotoxicosis related to IFNa has misdiagnosis between destructive thyrotoxicosis and Graves’ disease. Color-doppler ultrasonography might help in distinguish both and therefore start the right treatment. Considering CTLA-4 polymorphisms as genetic markers of thyroid disease in HCV patients, this project aims to characterize prospectively clinical aspects of thyroid disorders in patients infected with HCV before, during and after IFNa treatment associated or not to ribavirin and correlate the presence of thyroid disorder in these patients to CTLA-4 polymorphisms. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SEGURO DANILOVIC, DEBORA LUCIA; MENDES-CORREA, MARIA CASSIA; CHAMMAS, MARIA CRISTINA; ZAMBRINI, HEVERTON; BARROS, RAFFAELLE K.; MARUI, SUEMI. Thyroid disturbance related to chronic hepatitis C infection: role of CXCL10. ENDOCRINE JOURNAL, v. 60, n. 5, p. 583-590, . (06/06080-2)
DANILOVIC, DEBORA L. S.; MENDES-CORREA, MARIA C.; LIMA, ERIKA U.; ZAMBRINI, HEVERTON; BARROS, RAFFAELLE K.; MARUI, SUEMI. Correlations of CTLA-4 gene polymorphisms and hepatitis C chronic infection. LIVER INTERNATIONAL, v. 32, n. 5, p. 803-808, . (06/06080-2)
SEGURO DANILOVIC, DEBORA LUCIA; MENDES-CORREA, MARIA CASSIA; CHAMMAS, MARIA CRISTINA; ZAMBRINI, HEVERTON; MARUI, SUEMI. Thyroid hormonal disturbances related to treatment of hepatitis C with interferon-alpha and ribavirin. Clinics, v. 66, n. 10, p. 1757-1763, . (06/06080-2)

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