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Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)


The present study consists of two major subprojects. The first will evaluate new risk factors for preterm birth, such as components of two causality chains, i.e., the neuroendocrine and immune-inflammatory hypotheses. According to the first hypothesis, stress during pregnancy may favor the release of corticotrophin releasing factor (CRH) and the induction of preterm delivery potentiated by CRH gene polymorphisms. According to the second hypothesis, maternal infections may be potentiated by genetic susceptibility, promoting the liberation of inflammatory mediators leading to preterm birth. These hypotheses will be tested in a case-control study within a cohort started during the 5th month of prenatal care in a convenience sample covering 3.000 births in two cities, São Luís (MA) and Ribeirão Preto (SP). This cohort will be re-interviewed at birth and during the 1st year of life. The second subproject will evaluate indicators of perinatal health and their reflexes on preterm and low birth weight rates, comparing them to data for cohorts studied over the last thirty years in the two municipalities. We will also evaluate the impact of preterm birth and other birth conditions on growth, development of insulin resistance, neurological and behavioral alterations, risk factors for allergy and wheezing, and changes in oral health. This evaluation will be performed by interviewing the mothers, by anthropometric evaluation and blood collection for biochemical evaluation and by genetic studies of the children, by the application of allergy skin test and by dental evaluation. This cohort will be started at birth, covering a representative sample of 6000 births in São Luís and 7.500 births in Ribeirão Preto and will be re-evaluated during the first year of Iife. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Un batallón de nacimientos precoces 
Early-term births on the rise 
Before it’s time 
Antes de tiempo 
Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (22)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUNHA, GKP; BASTOS, L. B.; FREITAS, S. F.; CAVALLI, R. C.; QUINTANA, S. M. Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v. 129, n. 2 OCT 2021. Web of Science Citations: 2.
LUIZON, MARCELO R.; CONCEICAO, IZABELA M. C. A.; VIANA-MATTIOLI, SARAH; CALDEIRA-DIAS, MAYARA; CAVALLI, RICARDO C.; SANDRIM, VALERIA C. Circulating MicroRNAs in the Second Trimester From Pregnant Women Who Subsequently Developed Preeclampsia: Potential Candidates as Predictive Biomarkers and Pathway Analysis for Target Genes of miR-204-5p. FRONTIERS IN PHYSIOLOGY, v. 12, SEP 22 2021. Web of Science Citations: 0.
CRUZ DA SILVA QUEIROZ, RAFAELLE CRISTINA; DE SOUSA QUEIROZ, REJANE CHRISTINE; HERNANDES ROCHA, THIAGO AUGUSTO; SILVA, FRANCELENA DE SOUSA; DOS SANTOS, IZANI GONCALVES; DA SILVA, ISAIAS PEREIRA; DA SILVA, NUBIA CRISTINA; BARBIERI, MARCO ANTONIO; PEREIRA SARAIVA, MARIA DA CONCEICAO; MOURA DA SILVA, ANTONIO AUGUSTO. Vaccination services and incomplete vaccine coverage for children: a comparative spatial analysis of the BRISA cohorts, Sao Luis (Maranhao State) and Ribeirao Preto (Sao Paulo State), Brazil. Cadernos de Saúde Pública, v. 37, n. 6 2021. Web of Science Citations: 0.
F.M.M. BERNARDO; E.C.A. VEIGA; S.M. QUINTANA; F.J.A. CAMAYO; R.F.L. BATISTA; M.T.S.S.B. ALVES; H. BETTIOL; M.A. BARBIERI; V.C. CARDOSO; R.C. CAVALLI. Association of genitourinary infections and cervical length with preterm childbirth. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. -, 2021. Web of Science Citations: 0.
GRANDI, CARLOS; RODRIGUES, LIVIA DOS S.; ARAGON, DAVI C.; CARMONA, FABIO; CARDOSO, VIVIANE C. Weight/length ratio references and newborn body composition estimation at birth from a Brazilian cohort. Jornal de Pediatria, v. 97, n. 6, p. 610-616, 2021. Web of Science Citations: 1.
I.C. RODRIGUES; C. GRANDI; V.M.F. SIMÕES; R.F.L. BATISTA; L.S. RODRIGUES; V.C. CARDOSO. Metabolic profile during pregnancy in BRISA birth cohorts of Ribeirao Preto and Sao Luis, Brazil. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. -, 2021. Web of Science Citations: 0.
J.M.A. BARBOSA; A.A.M. DA SILVA; G. KAC; V.M.F. SIMÕES; H. BETTIOL; R.C. CAVALLI; M.A. BARBIERI; C.C.C. RIBEIRO. Is soft drink consumption associated with gestational hypertension? Results from the BRISA cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. -, 2021. Web of Science Citations: 1.
K.S.D. TROMBE; L.S. RODRIGUES; L.M.P. NASCENTE; V.M.F. SIMÕES; R.F.L. BATISTA; R.C. CAVALLI; C. GRANDI; V.C. CARDOSO. Is birth weight associated with pregestational maternal BMI? BRISA Cohort, Ribeirao Preto, Brazil. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. -, 2021. Web of Science Citations: 0.
L.A.B. MARTINS; E.C.A. VEIGA; C.C.C. RIBEIRO; V.M.F. SIMÕES; V.C. CARDOSO; H. BETTIOL; M.A. BARBIERI; R.C. CAVALLI. Uterine vascular resistance and other maternal factors associated with the risk of developing hypertension during pregnancy. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. -, 2021. Web of Science Citations: 0.
M.E.A. NEGRÃO; P.R.H. ROCHA; M.C.P. SARAIVA; M.A. BARBIERI; V.M.F. SIMÕES; R.F.L. BATISTA; A.A. FERRARO; H. BETTIOL. Association between tobacco and/or alcohol consumption during pregnancy and infant development: BRISA Cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. 10252-0, 2021. Web of Science Citations: 0.
OLIVEIRA SOUZA, MARILIA CRISTINA; SARAIVA, MARIA CONCEICAO PEREIRA; HONDA, MASATO; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; BARBOSA, FERNANDO; KANNAN, KURUNTHACHALAM. Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth. Environmental Research, v. 187, AUG 2020. Web of Science Citations: 0.
VIANA-MATTIOLI, SARAH; NUNES, PRISCILA; CAVALLI, RICARDO; SANDRIM, VALERIA. Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, APR 28 2020. Web of Science Citations: 0.
BARBOSA, RAPHAEL; SOARES BRITTO ALVES, MARIA TERESA SEABRA; NATHASJE, IAN; CHAGAS, DEYSIANNE; SIMOES, VANDA FERREIRA; SILVA, LEONARDO. Factors Associated with Inadequate Birth Intervals in the BRISA Birth Cohort, Brazil. Revista Brasileira de Ginecologia e Obstetrícia, v. 42, n. 2, p. 67-73, FEB 2020. Web of Science Citations: 0.
ROCHA, PAULO RICARDO H.; SARAIVA, MARIA DA C. P.; BARBIERI, MARCO A.; FERRARO, ALEXANDRE A.; BETTIOL, HELOISA. Association of preterm birth and intrauterine growth restriction with childhood motor development: Brisa cohort, Brazil. INFANT BEHAVIOR & DEVELOPMENT, v. 58, FEB 2020. Web of Science Citations: 0.
LÍGIA MOSCHEN DE PAULA NASCENTE; CARLOS GRANDI; DAVI CASALE ARAGON; VIVIANE CUNHA CARDOSO. Medidas placentárias e sua associação com o peso ao nascer em uma coorte brasileira. Revista Brasileira de Epidemiologia, v. 23, 2020-02-21.
JOÃO ROBERTO R. PIMENTA; CARLOS GRANDI; DAVI C. ARAGON; VIVIANE CUNHA CARDOSO. Comparison of birth weight, length, and head circumference between the BRISA-RP and Intergrowth-21st cohorts. Jornal de Pediatria, v. 96, n. 4, p. 511-519, Ago. 2020. Web of Science Citations: 0.
CALDEIRA-DIAS, MAYARA; MONTENEGRO, MARCELO F.; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE C.; CAVALLI, RICARDO C.; SANDRIM, VALERIA C. Resveratrol improves endothelial cell markers impaired by plasma incubation from women who subsequently develop preeclampsia. HYPERTENSION RESEARCH, v. 42, n. 8, p. 1166-1174, AUG 2019. Web of Science Citations: 0.
MAGNANI, PEDRO SERGIO; BETTIOL, HELOISA; MOURA DA SILVA, ANTONIO AUGUSTO; BARBIERI, MARCO ANTONIO; DE CARVALHO CAVALLI, RICARDO; OLIVEIRA BRITO, LUIZ GUSTAVO. Urinary incontinence between 12 and 24months postpartum: a cross-sectional study nested in a Brazilian cohort from two cities with different socioeconomic characteristics. INTERNATIONAL UROGYNECOLOGY JOURNAL, v. 30, n. 6, p. 1003-1011, JUN 2019. Web of Science Citations: 0.
DE REZENDE, MARCOS GONCALVES; GARCIA-LEAL, CYBELE; SILVA DE SA, MARCOS FELIPE; CAVALLI, RICARDO DE CARVALHO; DEL-BEN, CRISTINA MARTA. Withdrawal of plasma estradiol is associated with increased anxiety reported by women in the first 12 hours after delivery. PSYCHONEUROENDOCRINOLOGY, v. 101, p. 67-71, MAR 2019. Web of Science Citations: 1.
MARQUES, MELINA RODERO; GRANDI, CARLOS; DE PAULA NASCENTE, LIGIA MOSCHEN; CAVALLI, RICARDO CARVALHO; CARDOSO, VIVIANE CUNHA. Placental morphometry in hypertensive disorders of pregnancy and its relationship with birth weight in a Latin American population. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 13, p. 235-241, JUL 2018. Web of Science Citations: 1.
SANDRIM, VALERIA C.; CALDEIRA-DIAS, MAYARA; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE CUNHA; CAVALLI, RICARDO CARVALHO. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 0.
ROSA, CARLOS E.; SOARES, JAIR C.; FIGUEIREDO, FELIPE P.; CAVALLI, RICARDO C.; BARBIERI, MARCO A.; SCHAUFELBERGER, MARISTELA S.; SALMON, CARLOS E. G.; DEL-BEN, CRISTINA M.; SANTOS, ANTONIO C. Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 265, p. 18-25, JUL 30 2017. Web of Science Citations: 13.

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