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Synthesis of Drugs and bioactive substances from Morita-Baylis-Hillman adducts

Grant number: 06/06347-9
Support Opportunities:Regular Research Grants
Duration: January 01, 2007 - June 30, 2009
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Fernando Antonio Santos Coelho
Grantee:Fernando Antonio Santos Coelho
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


This research project has as main proposal the development of new synthetic strategies for the preparation of drugs and bioactive substances from natural sources. To achieve this proposal we intend to use Morita-Baylis-Hillman adducts as starting materials for the chemical transformations required. These adducts are easily prepared from commercial aldehydes and due to its synthetic versatility, they could be easily transformed into differents substances. This research project has also as proposal demonstrate the synthetic versatility of the Morita-Baylis-Hillman adducts and develop new technologies for a strategic brazilian industrial area, which is brazilian pharmaceutical industry. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PORTO, RICARDO S.; AMARANTE, GIOVANNI W.; CAVALLARO, MAYRA; POPPI, RONEI J.; COELHO, FERNANDO. Improved catalysis of Morita-Baylis-Hillman reaction. The strong synergic effect using both an imidazolic ionic liquid and a temperature. Tetrahedron Letters, v. 50, n. 11, p. 1184-1187, . (06/06347-9, 05/02373-2)
FERREIRA, BRUNO R. V.; PIROVANI, RODRIGO V.; SOUZA-FILHO, LUIS G.; COELHO, FERNANDO. Najera oxime-derived palladacycles catalyze intermolecular Heck reaction with Morita-Baylis-Hillman adducts. An improved and highly efficient synthesis of alpha-benzyl-beta-ketoesters. Tetrahedron, v. 65, n. 36, p. 7712-7717, . (06/06347-9)
PIROVANI, RODRIGO V.; FERREIRA, BRUNO R. V.; COELHO, FERNANDO. Highly Functionalized Spirocyclohexadienones from Morita-Baylis-Hillman Adducts. Synlett, n. 14, p. 2333-2337, . (06/06347-9)
AMARANTE‚ G.W.; REZENDE‚ P.; CAVALLARO‚ M.; COELHO‚ F.. Acyloins from Morita-Baylis-Hillman adducts: an alternative approach to the racemic total synthesis of bupropion. Tetrahedron Letters, v. 49, n. 23, p. 3744-3748, . (06/06347-9, 05/02373-2)

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