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Effect of erosive challenges and neutralizing agents on enamel microhardness: in vitro and in situ studies

Grant number: 06/04550-1
Support Opportunities:Regular Research Grants
Duration: December 01, 2006 - November 30, 2007
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Mônica Campos Serra
Grantee:Mônica Campos Serra
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


As the prevalence of non-carious destructive processes is rising, more emphasis is given to establish a better understanding of their risk factors and to develop appropriate preventive strategies.In vitro studies are important to the comprehension of the formation mechanism and to evaluate, in a controlled manner, factors related to the progression, prevention and control of the erosive wear. The firs in vitro investigation aims to establish adequate protocols to induce eroded lesions in bovine teeth, which would be relevant to further studies since bovine substrate has advantages of availability and larger sizes and flatter surfaces than human teeth.Considering that alkaline substances could neutralize acids in the oral cavity, the second in vitro study will access whether a baking soda solution has a neutralizing potential, able to influence the mineral equilibrium of eroded teeth. Clinically, several factors may interfere on the mineral content of enamel such as protective effect of saliva, acquired salivary pellicle, temperature and pH changes, and effects of foods and drinks on the oral environment. Whether the baking soda-containing dentifrices has some effect, under clinical influences, on the eroded enamel will be assessed on the in situ experiment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FURTADO MESSIAS, DANIELLE CRISTINE; NOGUEIRA MARTINS, MARA ELIZA; SERRA, MONICA CAMPOS; TURSSI, CECILIA PEDROSO. Feasibility of Using Sodium Bicarbonate Solution as a Damage-limiting Strategy for Erosion Lesions. ORAL HEALTH & PREVENTIVE DENTISTRY, v. 6, n. 2, p. 155-158, . (06/04550-1)

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