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Guided tissue regeneration: in vitro biocompatibility of a novel membrane of the composite poly(vinylidene-trifluoroethylene) /barium titanate

Grant number: 06/00779-4
Support Opportunities:Regular Research Grants
Duration: July 01, 2006 - June 30, 2008
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Márcio Mateus Beloti
Grantee:Márcio Mateus Beloti
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Guided tissue regeneration (GTR) is a technique that uses a barrier membrane, which can allow the repopulation of local sites by their own cells. The aim of this project is investigated the in vitro biocompatibility of a novel membrane of the composite poly(vinylidene-trifluoroethytele)/barium titanate (P(VDF-TrFE)/BT). Osteoblasts, fibroblasts and keratinocytes, cells that will be in contact with the membrane during GTR, will be cultivated on P(VDF-TrFE)/BT and e-PTFE (control) membranes and the following parameters will be evaluated: cell adhesion, proliferation, and viability, apoptosis, total protein content, collagen content, alkaline phosphatase (ALP) activity, and bone-like nodule formation for cultures of osteoblasts and fibroblasts; cell adhesion, proliferation, viability, and apoptosis for keratinocytes culture. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEIXEIRA, L. N.; CRIPPA, G. E.; LEFEBVRE, L. -P.; DE OLIVEIRA, P. T.; ROSA, A. L.; BELOTI, M. M.. The influence of pore size on osteoblast phenotype expression in cultures grown on porous titanium. International Journal of Oral and Maxillofacial Surgery, v. 41, n. 9, p. 1097-1101, . (06/00779-4)

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