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Synthesis and biological evaluation of dihydropyranones: anguinomicyn and fostriecin and goniothalamin analogues

Grant number: 06/00368-4
Support Opportunities:Regular Research Grants
Duration: May 01, 2006 - October 31, 2009
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Ronaldo Aloise Pilli
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The research proposal aims to develop the synthesis and to investigate the biological profile (cytotoxic activity against human cancer cell lines and phosphatase inhibition)of several compounds displaying the dihydropyranone moiety. We will focus on the synthesis and biological activities of (S)-goniothalamin analogues, fostriecine analogues and anguinomicin C. For anguinomycin C we aim to establish its relative and absolute configuration by total synthesis. (AU)

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