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Use of nanocarriers containing photosensitive dyes and other derived and growing factors applied to the photodynamic process in the health areas

Grant number: 08/53719-4
Support Opportunities:Research Projects - Thematic Grants
Duration: December 01, 2008 - February 28, 2013
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Antonio Claudio Tedesco
Grantee:Antonio Claudio Tedesco
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Ésper Abrão Cavalheiro


An enormous variety of new therapies has been emerging in the last years as a consequence of progresses in the field of the sciences and the new technologies applied to biological systems. The common fact to all of this proposed new therapeutics is that in many of them that come as innovation is basically the rediscovered of old drugs as ‘new design’. It understands as a ‘new design’, new and efficient systems of drug delivery system, used with the intention of resuscitating old and excellent active drugs, which in the course of time left of being used due to the amount of side effects detected after long time of attendance, as well as, no viability of production and other factors. This new tendency has been found support and partnership in pharmaceutical industries of medium and great capacity, which noticed that the modifications of the vehicle of administration for some drugs can provide new strategies in the market of products that have been in market for years, with the in vivo test and therapeutic efficiency proved. Besides, the wide accumulation of scientific knowledge for each active drug will help in the agility of the technology transfer process. Allied to this new tendency appears new therapies based in a control and precise activation process of the drugs, be modulated by complementary agents as light (in the case of the photodynamic process), or magnetic field (in the case of the hyperthermia effects), or still for other external agents to not incorporate directly in the drug-DDS complex. Such new therapeutics is focused in treatment of cancer and other pathologies, as examples, dentistry, veterinary, neurological diseases, neuro-orthopedical and, more recently, the tissue engineering. Associated to these news DDS we can incorporate many biocompatible markers that will allow to monitor the biodistribution of the drug in the body, and in many cases also to address the accumulation of the same ones to the biological target (as cells, tissue, organs, and microorganisms). This concept has already been applied with success in the treatment of the skin cancer with very good results obtained in clinical trial developed in tree ambulatory structures already existent in the country. In the dentistry the studies and treatments for carie and, endodontic and periodontic diseases already reached also clinical status in several research centers (Sao Paulo, Ribeirao Preto). In the other areas, as veterinary, neurology and neuro-orthopedics, the studies alive in (small animals) are running very well and they should allow studies phase one ( in human) very soon . The research project proposes here the development of new drug delivery systems for application of drugs and active principles to four areas of the health. Standing out: I-Oncology (skin cancer and other neoplastic diseases), deepening the studies in this area and expanding them for deeper skin cancer, and for other cancer tissue, as lap, bladder, prostate and mamma; II- Tissue Engineering, using the experiences and these success of 35 year of studies involving photodynamic therapies applied to the cancer, to treat and to modulate her restoration of other countless cuttaneous process as wound repair, as well as, restoring the activity of the cuttaneous transplanted tissue in patients that need this new technology; Ill-Neuro-orthopedics, making the use of these new nanoestructured systems associates with biocompatible carbon nanotubes, to allow the restoration of terminal nervous and neuronal growth in outlying organs; IV-Neurological Disturbances (oncology and epilepsy), gone back to study of neoplastic diseases of cerebral trunk cancer through experimental models treated with photosensitive drug nanocarries in a special way to over the brain blood barrier. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PRIMO, F. L.; DE PAULA, L. B.; DE SIQUEIRA-MOURA, M. P.; TEDESCO, A. C.. Photobiostimulation on Wound Healing Treatment by ClAlPc-nanoemulsion from a Multiple-Wavelength Portable Light Source on a 3D-Human Stem Cell Dermal Equivalent. Current Medicinal Chemistry, v. 19, n. 30, p. 5157-5163, . (08/53719-4)
VACCARI, C. B.; CERIZE, N. N. P.; MORAIS, P. C.; RE, M. I.; TEDESCO, A. C.. Biocompatible Magnetic Microspheres for Use in PDT and Hyperthermia. Journal of Nanoscience and Nanotechnology, v. 12, n. 6, p. 5111-5116, . (08/53719-4)
SEGUIER, SYLVIE; SOUZA, SERGIO L. S.; SVERZUT, ANNA C. V.; SIMIONI, ANDREZA R.; PRIMO, FERNANDO L.; BODINEAU, AGNES; CORREA, VANI M. A.; COULOMB, BERNARD; TEDESCO, ANTONIO C.. Impact of photodynamic therapy on inflammatory cells during human chronic periodontitis. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 101, n. 3, p. 348-354, . (08/53719-4)
PEREIRA RIBEIRO, JEFFERSON BRUNO; MIRANDA-VILELA, ANA LUISA; GRAZIANI, DANIEL; DE AGUIAR GOMES, MISLEIA RODRIGUES; SANTAREM AMORIM, ANA ANGELICA; GARCIA, RAFAELA DEBASTIANI; DE SOUZA FILHO, JOSE; TEDESCO, ANTONIO CLAUDIO; PRIMO, FERNANDO LUCAS; MOREIRA, JONATHAN ROSA; et al. Evaluation of the efficacy of systemic miltefosine associated with photodynamic therapy with liposomal chloroaluminium phthalocyanine in the treatment of cutaneous leishmaniasis caused by Leishmania (L.) amazonensis in C57BL/6 mice. Photodiagnosis and Photodynamic Therapy, v. 13, p. 282-290, . (08/53719-4)
FEUSER, PAULO EMILIO; FERNANDES, ANDRIELLE CASTILHO; NELE, MARCIO; VIEGAS, ALEXANDRE DA CAS; RICCI-JUNIOR, EDUARDO; TEDESCO, ANTONIO CLAUDIO; SAYER, CLAUDIA; HERMES DE ARAUJO, PEDRO HENRIQUE. Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 135, p. 357-364, . (08/53719-4)
BOLFARINI, GISELE C.; SIQUEIRA-MOURA, MARIGILSON P.; DEMETS, GREGOIRE J. F.; TEDESCO, ANTONIO C.. Preparation, characterization, and in vitro phototoxic effect of zinc phthalocyanine cucurbit[7]uril complex encapsulated into liposomes. DYES AND PIGMENTS, v. 100, p. 162-167, . (08/53719-4)
LEANDRO, FERNANDA Z.; MARTINS, JULIA; FONTES, APARECIDA M.; TEDESCO, ANTONIO C.. Evaluation of theranostic nanocarriers for near-infrared imaging and photodynamic therapy on human prostate cancer cells. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 154, p. 341-349, . (13/50181-1, 08/53719-4)
SIMIONI, ANDREZA RIBEIRO; PRIMO, FERNANDO L.; TEDESCO, ANTONIO CLAUDIO. Silicon(IV) phthalocyanine-loaded-nanoparticles for application in photodynamic process. JOURNAL OF LASER APPLICATIONS, v. 24, n. 1, . (08/53719-4)
DE PAULA, LEONARDO B.; PRIMO, FERNANDO L.; PINTO, MARCELO R.; MORAIS, PAULO C.; TEDESCO, ANTONIO C.. Combination of hyperthermia and photodynamic therapy on mesenchymal stem cell line treated with chloroaluminum phthalocyanine magnetic-nanoemulsion. Journal of Magnetism and Magnetic Materials, v. 380, p. 372-376, . (14/14231-7, 08/53719-4)
DE PAULA, L. B.; PRIMO, F. L.; JARDIM, D. R.; MORAIS, P. C.; TEDESCO, A. C.. Development, characterization, and in vitro trials of chloroaluminum phthalocyanine-magnetic nanoemulsion to hyperthermia and photodynamic therapies on glioblastoma as a biological model. Journal of Applied Physics, v. 111, n. 7, . (08/53719-4)
FALQUEIRO, A. M.; SIQUEIRA-MOURA, M. P.; JARDIM, D. R.; PRIMO, F. L.; MORAIS, P. C.; MOSINIEWICZ-SZABLEWSKA, E.; SUCHOCKI, P.; TEDESCO, A. C.. In vitro cytotoxicity of Selol-loaded magnetic nanocapsules against neoplastic cell lines under AC magnetic field activation. Journal of Applied Physics, v. 111, n. 7, . (09/13208-3, 08/53719-4)
FERREIRA, D. M.; SAGA, Y. Y.; ALUICIO-SARDUY, E.; TEDESCO, A. C.. Chitosan Nanoparticles for Melanoma Cancer Treatment by Photodynamic Therapy and Electrochemotherapy Using Aminolevulinic Acid Derivatives. Current Medicinal Chemistry, v. 20, n. 14, p. 1904-1911, . (08/53719-4)
SIQUEIRA-MOURA, MARIGILSON P.; PRIMO, FERNANDO L.; ESPREAFICO, ENILZA M.; TEDESCO, ANTONIO C.. Development, characterization, and photocytotoxicity assessment on human melanoma of chloroaluminum phthalocyanine nanocapsules. Materials Science & Engineering C-Materials for Biological Applications, v. 33, n. 3, p. 1744-1752, . (08/53719-4)
PRIMO, F. L.; DA COSTA REIS, M. B.; PORCIONATTO, M. A.; TEDESCO, A. C.. In Vitro Evaluation of Chloroaluminum Phthalocyanine Nanoemulsion and Low-Level Laser Therapy on Human Skin Dermal Equivalents and Bone Marrow Mesenchymal Stem Cells. Current Medicinal Chemistry, v. 18, n. 22, p. 3376-3381, . (08/53719-4)

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