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Novel analytical strategies for studies involving biomolecules


Novel analytical strategies involving bio-molecules, such as e.g. enzymes, metalloenzymes and metalloproteins will be implemented, with emphasis to use of biomarkers for evaluating tolerance to oxidative stress. Analytical procedures will be developed for the determination of anti-oxidants, markers of oxidative damage, metals and proteins; novel non-destructive methodologies for fast in-situ analysis in biological materials presenting high heterogeneity in structure and high variability in shape. The feasibility of exploiting isotope fractioning for evaluation of biochemical processes involving metals and biomolecules will be investigated. Furthermore, multi-pumping flow systems will be designed for direct analyses of the protein spots as well as for implementing mini-columns of biomaterials for pesticide determination. The acquired knowledge will be disseminated and the project development will be evaluated and re-directioned through workshops involving all the participants. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FORTES, PAULA R.; FERES, MARIO A.; ZAGATTO, ELIAS A. G.; LIMA, JOSE L. F. C.. Sequential injections as an alternative to gradient exploitation for implementing differential kinetic analysis in a flow injection system. Talanta, v. 81, n. 4-5, p. 1409-1412, . (06/03859-9, 06/07309-3)
VIDA, ANA C. F.; SASAKI, MILTON K.; GOMES, TACIANA F.; SILVA, CLAUDINEIA R.; FERES, MARIO A.; ZAGATTO, E. A. G.. Zone trapping/merging zones in flow analysis: A novel approach for rapid assays involving relatively slow chemical reactions. Talanta, v. 85, n. 1, p. 259-263, . (10/00972-4, 06/07309-3)
BAPTISTAO, MARIANA; DE CARVALHO ROCHA, WERICKSON FORTUNATO; POPPI, RONEI JESUS. Quality control of the paracetamol drug by chemometrics and imaging spectroscopy in the near infrared region. Journal of Molecular Structure, v. 1002, n. 1-3, p. 167-171, . (06/07309-3)
CARLOS, CAMILA; MARETTO, DANILO A.; POPPI, RONEI J.; SATO, MARIA INES Z.; OTTOBONI, LAURA M. M.. Fourier transform infrared microspectroscopy as a bacterial source tracking tool to discriminate fecal E. coli strains. Microchemical Journal, v. 99, n. 1, p. 15-19, . (06/07309-3)
ROCHA‚ W.F.C.; POPPI‚ R.J.. Multivariate control charts based on net analyte signal (NAS) and Raman spectroscopy for quality control of carbamazepine. Analytica Chimica Acta, v. 705, n. 1, p. 35-40, . (06/07309-3)
SILVA, CLAUDINEIA R.; BARROS, VALDEMIR A. F.; BASSO, LUIZ C.; ZAGATTO, ELIAS A. G.. Spectrophotometric flow injection monitoring of sulfide during sugar fermentation. Talanta, v. 85, n. 3, p. 1703-1705, . (10/00972-4, 06/07309-3)
CARNEIRO, RENATO LAJARIM; POPPI, RONEI JESUS. Infrared imaging spectroscopy and chemometric tools for in situ analysis of an imiquimod pharmaceutical preparation presented as cream. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 118, p. 215-220, . (06/07309-3)
VALDERRAMA, PATRICIA; POPPI, RONEI JESUS. Determination of propranolol enantiomers in plasma and urine by spectrofluorimetry and second-order standard addition method. Analytica Chimica Acta, v. 651, n. 1, p. 31-35, . (06/07309-3)
FRACASSI DA SILVA, JOSE ALBERTO; DE CASTRO, NATHAN VITORAZZI; DE JESUS, DOSIL PEREIRA; FARIA, ADRIANA F.; DE SOUZA, MARCUS V. N.; LEAL DE OLIVEIRA, MARCONE AUGUSTO. Fast determination of ethambutol in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. ELECTROPHORESIS, v. 31, n. 3, p. 570-574, . (06/07309-3)
DIAS, A. C. B.; FIGUEIREDO, E. C.; GRASSI, V.; ZAGATTO, E. A. G.; ARRUDA, M. A. Z.. Molecularly imprinted polymer as a solid phase extractor in flow analysis. Talanta, v. 76, n. 5, p. 988-996, . (06/07309-3)
CARNEIRO, RENATO LAJARIM; POPPI, RONEI JESUS. Homogeneity study of ointment dosage forms by infrared imaging spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, v. 58, p. 42-48, . (06/07309-3)
SABIN, GUILHERME P.; BREITKREITZ, MARCIA C.; DE SOUZA, ANDRE M.; DA FONSECA, PATRICIA; CALEFE, LUPERCIO; MOFFA, MARIO; POPPI, RONEI J.. Analysis of pharmaceutical pellets: An approach using near-infrared chemical imaging. Analytica Chimica Acta, v. 706, n. 1, p. 113-119, . (06/07309-3)
SABIN, GUILHERME POST; DE CARVALHO ROCHA, WERICKSON FORTUNATO; POPPI, RONEI JESUS. Study of the similarity between distribution maps of concentration in near-infrared spectroscopy chemical imaging obtained by different multivariate calibration approaches. Microchemical Journal, v. 99, n. 2, p. 542-547, . (06/07309-3)
FERES‚ M.A.; FORTES‚ P.R.; ZAGATTO‚ E.A.G.; SANTOS‚ J.L.M.; LIMA‚ J.L.F.C.. Multi-commutation in flow analysis: Recent developments and applications. Analytica Chimica Acta, v. 618, n. 1, p. 1-17, . (06/07309-3, 06/03859-9, 06/03718-6)

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