| Grant number: | 98/11119-7 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Duration: | January 01, 1999 - February 29, 2004 |
| Field of knowledge: | Biological Sciences - Biochemistry - Molecular Biology |
| Principal Investigator: | Carlos Frederico Martins Menck |
| Grantee: | Carlos Frederico Martins Menck |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Pesquisadores principais: | Márcio de Castro Silva Filho ; Marie-Anne van Sluys |
| Associated scholarship(s): | 01/00963-6 - Complementation of the DNA repair deficiency in human cells by transducing the gene XPC cDNA with recombinant adenovirus,
BP.MS 01/01728-0 - Complementation of the DNA repair deficiency in human cells by transducing the gene XPA cDNA with recombinant adenovirus, BP.PD 99/03419-3 - Complementation of the DNA repair deficiency in human cells by transferring the gene XPC with recombinant adenovirus, BP.IC |
Abstract
The proposal aims to study different aspects of the Molecular Biology of the repair of injured DNA in various systems. In animal cells we are developing genetic vectors to intervene in the repair system and thus obtain information on how these act on some levels, such as, for example, apoptosis, mutagenesis and recombination. In plants we are trying to identify functions of two genes (araXPB and thi1) cloned by us in the repair of DNA, either through in vitro trials or in the construction of transgenetic plants modified by these genes. Finally, we are continuing the previous work in which we studied the repair mechanisms of bacterial DNA responsible for the protection of the genome against lesions induced by singlet oxygen. (AU)
| Articles published in Pesquisa FAPESP Magazine about the research grant: |
| Subtle damage from the sun |
| Los sutiles daños causados por el Sol |
| Subtle damage from the sun |
| Articles published in Agência FAPESP Newsletter about the research grant: |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |