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Recognition of carbohydrates: roles played in the parasite-host realtionship

Abstract

The importance of the participation of sugar recognition for the relationship established between host and pathogens motivates our proposal to study the protein-carbohydrate interactions on the following situations: a) to identify and to characterize parasite lectins, evaluating their capacity to interfere with host defense mechanisms. We intend to study the pathogens Paracoccidioides brasiliensis, Toxoplasma gondii and Shistosoma mansoni; b) to evaluate the role of two mammalian lectins-NNCF and galectin-3 on the relationship between the host and two different protozoa, Trypanosoma cruzi and Leishmania major; c) to evaluate the adjuvant effect exerted by a plant lectin, which is believed to induce, through the stimulus of IL-12 production, protection against L. major and T gondii infection. Lectins will be used as tools in the following satellite projects: a) to study mast cell recruitment, stimulated by lectins; b) to isolate the IFN-Y receptor of T gondii. The importance of the participation of sugar recognition for the relationship established between host and pathogens motivates our proposal to study the protein-carbohydrate interactions on the following situations: a) to identify and to characterize parasite lectins, evaluating their capacity to interfere with host defense mechanisms. We intend to study the pathogens Paracoccidioides brasiliensis, Toxoplasma gondii and Shistosoma mansoni; b) to evaluate the role of two mammalian lectins, NNCF and galectin-3 on the relationship between the host and two different protozoa, Trypanosoma cruzi and Leishmania major; c) to evaluate the adjuvant effect exerted by a plant lectin, which is believed to induce, through the stimulus of IL-12 production, protection against L. major and T gondii infection. Lectins will be used as tools in the following satellite projects: a) to study mast cell recruitment, stimulated by lectins; b) to isolate the IFN-Y receptor of T gondii. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RUAS, LUCIANA P.; CARVALHO, FERNANDA C.; ROQUE-BARREIRA, MARIA-CRISTINA. ArtinM offers new perspectives in the development of antifungal therapy. FRONTIERS IN MICROBIOLOGY, v. 3, . (06/60642-2, 00/09333-2)
COLTRI, KELY C.; OLIVEIRA, LEANDRO L.; RUAS, LUCIANA P.; VENDRUSCOLO, PATRICIA E.; GOLDMAN, MARIA HELENA; PANUNTO-CASTELO, ADEMILSON; ROQUE-BARREIRA, MARIA-CRISTINA. Protection against Paracoccidioides brasiliensis infection conferred by the prophylactic administration of native and recombinant ArtinM. Medical Mycology, v. 48, n. 6, p. 792-799, . (06/60642-2, 00/09333-2)
LOURENÇO‚ E.V.; PEREIRA‚ S.R.; FAÇA‚ V.M.; COELHO-CASTELO‚ A.A.M.; MINEO‚ J.R.; ROQUE-BARREIRA‚ M.C.; GREENE‚ L.J.; PANUNTO-CASTELO‚ A.. Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin. GLYCOBIOLOGY, v. 11, n. 7, p. 541-547, . (00/09333-2)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

COMPOSIÇÃO FARMACÊUTICA PARA PREVENIR E CICATRIZAR LESÕES EPITELIAIS, COMPOSIÇÃO FARMACÊUTICA IMUNOMODULADORA, COMPOSIÇÃO FARMACÊUTICA PARA TRATAR TOXOPLASMOSE, COMPOSIÇÃO FARMACÊUTICA, COMPOSIÇÃO INSETICIDA, INSETICIDA, USO DE LECTINA KM+ PARA TRATAR CICATRIZAÇÕES, USO DE LECTINA KM+ PARA TRATAR TOXOPLASMOSE, USO DE LECTINA KM+ PARA PREPARAR MEDICAMENTO PARA TRATAR TOXOPLASMOSE, USO DE LECTINA KM+ PARA PREPARAR MEDICAMENTO IMUNOMODULADOR, USO DA LECTINA KM+ PARA PREPARAR MEDICAMENTO ANTI-BACTERIANO, USO DE LECTINA KM+ PARA PREPARAR MEDICAMENTO ANTI-VIRAL, MÉTODO DE EXPRESSÃO, VETOR DE DNA, ORGANISMO RECOMBINANTE, SEQÜÊNCIA DE NUCLEOTÍDEOS, PROTEÍNAS, ANTICORPO E PLASMÍDEO PI0301547-5 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Luis Lamberti Pinto da Silva; Ademilson Panunto Castelo; Maria Helena de Souza Goldman; Maria Cristina Roque Antunes Barreira; Ricardo Santos de Oliveira; Marcelo Dias Baruffi; Jeanne Blanco de Molfetta Machado - May 2003, 19

COMPOSICION FARMACEUTICA QUE COMPRENDE LECTINA KM+ AR044389 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Luis Lamberti Pinto da Silva; Ademilson Panunto Castelo; Maria Helena de Souza Goldman; Maria Cristina Roque Antunes Barreira; Ricardo Santos de Oliveira; Marcelo Dias Baruffi; Jeanne Blanco de Molfetta Machado - May 2004, 18

COMPOSIÇÃO FARMACÊUTICA PARA PREVENIR RODOCOCOSE EQÜINA, VACINA PARA PREVENÇÃO DE RODOCOCOSE EQÜINA, USO DE LINHAGEM ATENUADA BACTERIANA PARA PREPARAR VACINA PARA PREVENÇÃO DA RODOCOCOSE EQÜINA, USO DE LINHAGEM ATENUADA BACTERIANA PARA PREPARAR COMPOSIÇÃO FARMACÊUTICA PARA PREVENÇÃO DA RODOOCCOSE EQÜINA, PROCESSO DE PREPARAÇÃO DE LINGUAGEM ATENUADA BACTERIANA PI0506364-7 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) . Maria Cristina Roque Antunes Barreira; Marcelo Brocchi; Aline Ferreira de Oliveira Pereira; Luciana Colbachini Ferraz; Ana Carolina Rusca Correa Porto; Luis Eduardo dos Santos Ferraz - December 2005, 21