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Phytochemistry and chemical ecology: search for starter compounds for new insecticidal, fungicidal and bactericidal drugs for control of plant pests

Abstract

The central theme of this Project is isolation and structure elucidation of plant secondary metabolites and the application of findings to the investigation of a wide range of problems including: 1. The ecological importance of secondary metabolites in shaping Citrus/insect/fungus/bacteria/enzymes interactions. In order to attend this subject the objectives are: a) The search of target compounds for antibacterial drug design to Xyllela fastidiosa; b) The search of target compounds for insecticide drug design to insect vector of Xyllela fastidiosa; c) The search of target compounds for fungicide drug design to Guignardia citricarpa; d) In order to determine if secondary metabolites present in Citrus limon stock could be translocated to the C. sinensis graft, the biosynthesis of coumarins will be studied by prenyltransferase; e) The ecological importance of secondary metabolites in shaping Citrus/Apis mellifera. 2. The ecological importance of secondary metabolites in chaping Meliaceae/H. grandella: In order to attend this subject the objectives are: a) The search of target compounds for insecticide drug design to H. grandella in Swietenia macrophylla; b) The search of target compounds for insecticide drug design to H. grandella in Khaya ivorensis; c) The search of target compounds for insecticide drug design to H. grandella in Azadirachta indica grafted on Melia azedarach; d) Syntheses and characterization of female pheromone of H. grandella and their use in Meliaceae plantation. 3. The ecological importance of secondary metabolites in shaping Meliaceae/Termites: in order to attend this subject the objectives are: a) The search of target compounds for insecticide drug design to Heterotermes tenuis in Meliaceae resistant to termites; b) Syntheses and characterization of female pheromone of H. grandella and their application. (AU)

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