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Peptidergic pathways involved in the organization of feeding behavior

Grant number: 04/13849-5
Support Opportunities:Research Projects - Thematic Grants
Duration: May 01, 2005 - April 30, 2010
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Jackson Cioni Bittencourt
Grantee:Jackson Cioni Bittencourt
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Últimos )
Gilberto Fernando Xavier
Pesquisadores principais:
( Antigos )
Newton Sabino Canteras
Associated scholarship(s):07/56975-9 - Study of melanin-concentrating hormone (MCH) immunoreactive inputs of nucleus acumbens, in rats Long-Evans , BP.MS


Feeding behavior is an essential part of the energy balance control. It allows the maintenance of health and an adequate body weight. In the last years, the description of leptin action as a lipostatic or satiety factor in the hypotha1amus originated a burst of information about its action in food intake control and related disorders (obesity and anorexia). In parallel, an increasing number of peptides and receptors implicated in energy homeostasis have invaded the field. In this regard, melanin-concentrating hormone (MCH) has been related to the tonic control of feeding. MCH neurons are located in the hypothalamus, what made it a natural candidate for neuroendocrine, autonomic and behavioral control of the homeostasis and species subsistence. Accordingly, various findings support MCH action in feeding behavior: 1) MCH mRNA is abundant in fasted animals or obese (ob/ob) mice; 2) MCH administration in the cerebral ventricles or in specific hypothalamic nuclei that express MCH receptor (MCH -IR) induces hyperphagia and increases body weight; 3) MCH knock-out mice shows decreased body weight due to hypophagia and rise in energy expenditure; 4) MCH-IR knock-out mice are lean albeit hyperphagic; 5) administration of MCH-IR specific antagonists decreases body weight gain. Intriguingly however, the brain sites where MCH mar act inducing feeding, and the cell biology of these putative systems are not completely understood. It is important to point out that feeding is a complex behavior that includes homeostatic and hedonistic mechanisms, embracing since hunger sensation until motor activity, exploratory behavior, emotional responses, anxiety, memory and learning processes. Therefore, this study attempts to investigate MCH action in various feeding aspects and the related circuitry. Initially, we plain to analyze MCH participation in spatial orientation in the search for food, using a maze paradigm and different types of food: only nutritional or with hedonic value. In addition, using the same paradigm we propose to investigate the animal performance following lesion, or injection of MCH or anti-MCH in specific brain nuclei previously identified. In these regions, we intend to investigate the neurochemistry, the occurrence of synaptic terminals using electron microscopy, and describe the synaptic characterization. Finally, we aim to look into MCH role in complex systems of search for food that include predatory behavior. (AU)

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Scientific publications (23)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AYALA, CAROLINA; RUTH VALDEZ, SUSANA; LUJAN NAVARRA MORERO, MARIA; SOAJE, MARTA; BEATRIZ CARRENO, NORMA; SILVINA SANCHEZ, MONICA; BITTENCOURT, JAKSON CIONI; ALMA JAHN, GRACIELA; ESTER CELIS, MARIA. Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats. Peptides, v. 32, n. 6, p. 1249-1254, . (04/13849-5)
MASCARO, MARCELO B.; PROSDOCIMI, FABIO C.; BITTENCOURT, JACKSON C.; ELIAS, CAROL F.. Forebrain projections to brainstem nuclei involved in the control of mandibular movements in rats. European Journal of Oral Sciences, v. 117, n. 6, p. 676-684, . (04/13849-5)
RONDINI, TATIANE ARAUJO; DONATO, JR., JOSE; RODRIGUES, BRUNO DE CRUDIS; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Chemical identity and connections of medial preoptic area neurons expressing melanin-concentrating hormone during lactation. Journal of Chemical Neuroanatomy, v. 39, n. 1, p. 51-62, . (04/13849-5)
LIMA, FERNANDO F. B.; SITA, LUCIANE V.; OLIVEIRA, AMANDA R.; COSTA, HELDER C.; DA SILVA, JOELCIMAR M.; MORTARA, RENATO A.; HAEMMERLE, CARLOS A. S.; XAVIER, GILBERTO F.; CANTERAS, NEWTON S.; BITTENCOURT, JACKSON C.. Hypothalamic melanin-concentrating hormone projections to the septo-hippocampal complex in the rat. Journal of Chemical Neuroanatomy, v. 47, p. 1-14, . (07/56975-9, 04/13849-5)
BATTAGELLO, DANIELLA S.; DINIZ, GIOVANNE B.; CANDIDO, PAULO L.; DA SILVA, JOELCIMAR M.; DE OLIVEIRA, AMANDA R.; DA SILVA, KELLY R. TORRES; LOTFI, CLAUDIMARA F. P.; DE OLIVEIRA, JOSE A.; SITA, LUCIANE V.; CASATTI, CLAUDIO A.; et al. Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. FRONTIERS IN NEUROANATOMY, v. 11, . (12/08833-9, 12/03067-6, 16/02224-1, 16/02748-0, 04/13849-5, 11/09816-8, 09/06769-9)
BITTENCOURT, JACKSON; CELIS, MARIA ESTER. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides, v. 29, n. 8, p. 1441-1450, . (04/13849-5)
SITA, LUCIANE VALERIA; DINIZ, GIOVANNE BARONI; CANTERAS, NEWTON SABINO; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI. Effect of intrahippocampal administration of anti-melanin-concentrating hormone on spatial food-seeking behavior in rats. Peptides, v. 76, p. 130-138, . (04/13849-5)
GLEZER, ISAIAS; BITTENCOURT, JACKSON C.; RIVEST, SERGE. Neuronal Expression of Cd36, Cd44, and Cd83 Antigen Transcripts Maps to Distinct and Specific Murine Brain Circuits. JOURNAL OF COMPARATIVE NEUROLOGY, v. 517, n. 6, p. 906-924, . (04/13849-5, 07/53732-8)
DONATO, JR., JOSE; CAVALCANTE, JUDNEY CLEY; SILVA, RENATA JULIANA; TEIXEIRA, ALINE STAVIN; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Male and female odors induce Fos expression in chemically defined neuronal population. Physiology & Behavior, v. 99, n. 1, p. 67-77, . (04/13849-5)
DONATO, JR., JOSE; SILVA, RENATA J.; SITA, LUCIANE V.; LEE, SYANN; LEE, CHARLOTTE; LACCHINI, SILVIA; BITTENCOURT, JACKSON C.; FRANCI, CELSO R.; CANTERAS, NEWTON S.; ELIAS, CAROL F.. The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion. JOURNAL OF NEUROSCIENCE, v. 29, n. 16, p. 5240-5250, . (04/13849-5, 05/59286-4, 04/09638-9)
MOTA-ORTIZ, SANDRA REGINA; SUKIKARA, MARCIA HARUMI; BITTENCOURT, JACKSON CIONI; BALDO, MARCUS VINICIUS; ELIAS, CAROL FUZETI; FELICIO, LUCIANO FREITAS; CANTERAS, NEWTON SABINO. The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting. Behavioural Brain Research, v. 226, n. 1, p. 32-40, . (04/13849-5)
CESPEDES, ISABEL C.; DE OLIVEIRA, AMANDA R.; DA SILVA, JOELCIMAR M.; DA SILVA, ANDRE V.; SITA, LUCIANE V.; BITTENCOURT, JACKSON C.. mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration. Peptides, v. 31, n. 12, p. 2200-2208, . (04/13849-5)
ELIAS, C. F.; SITA, L. V.; ZAMBON, B. K.; OLIVEIRA, E. R.; VASCONCELOS, L. A. P.; BITTENCOURT, J. C.. Melanin-concentrating hormone projections to areas involved in somatomotor responses. Journal of Chemical Neuroanatomy, v. 35, n. 2, p. 188-201, . (04/13849-5)
SITA, L. V.; ELIAS, C. F.; BITTENCOURT, J. C.. Connectivity pattern suggests that incerto-hypothalamic area belongs to the medial hypothalamic system. Neuroscience, v. 148, n. 4, p. 949-969, . (04/13849-5)
CAVALCANTE, JUDNEY CLEY; BITTENCOURT, JACKSON CIONI; ELIAS, CAROL FUZETI. Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats. Brain Research, v. 1582, p. 77-90, . (05/59286-4, 04/13849-5)
DA SILVA, ANDRE V.; TORRES, KELLY R.; HAEMMERLE, CARLOS A.; CESPEDES, ISABEL C.; BITTENCOURT, JACKSON C.. The Edinger-Westphal nucleus II: Hypothalamic afferents in the rat. Journal of Chemical Neuroanatomy, v. 54, p. 5-19, . (04/13849-5)
BITTENCOURT, JACKSON C.. Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain. General and Comparative Endocrinology, v. 172, n. 2, p. 185-197, . (04/13849-5)
KOZICZ, TAMAS; BITTENCOURT, JACKSON C.; MAY, PAUL J.; REINER, ANTON; GAMLIN, PAUL D. R.; PALKOVITS, MIKLOS; HORN, ANJA K. E.; TOLEDO, CLAUDIO A. B.; RYABININ, ANDREY E.. The Edinger-Westphal Nucleus: A Historical, Structural, and Functional Perspective on a Dichotomous Terminology. JOURNAL OF COMPARATIVE NEUROLOGY, v. 519, n. 8, p. 1413-1434, . (04/13849-5)
PINATO, LUCIANA; CRUZ-MACHADO, SANSERAY DA SILVEIRA; FRANCO, DAIANE G.; CAMPOS, LEILA M. G.; CECON, ERIKA; FERNANDES, PEDRO A. C. M.; BITTENCOURT, JACKSON C.; MARKUS, REGINA P.. Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis. Brain Structure & Function, v. 220, n. 2, p. 827-840, . (04/13849-5, 11/51495-4, 07/07871-6)
RONDINI‚ T. A.; DE CRUDIS RODRIGUES‚ B.; DE OLIVEIRA‚ A. P.; BITTENCOURT‚ J. C.; ELIAS‚ C. F.. Melanin-concentrating hormone is expressed in the laterodorsal tegmental nucleus only in female rats. Brain Research Bulletin, v. 74, n. 1/3, p. 21-28, . (04/13849-5)
DOS SANTOS JUNIOR, EDMILSON D.; DA SILVA, ANDRE V.; DA SILVA, KELLY R. T.; HAEMMERLE, CARLOS A. S.; BATAGELLO, DANIELLA S.; DA SILVA, JOELCIMAR M.; LIMA, LEANDRO B.; DA SILVA, RENATA J.; DINIZ, GIOVANNE B.; SITA, LUCIANE V.; et al. The centrally projecting Edinger-Westphal nucleus-I: Efferents in the rat brain. Journal of Chemical Neuroanatomy, v. 68, p. 22-38, . (07/56975-9, 04/13849-5, 08/02771-6, 11/09816-8)
PACHECO FERREIRA, JOZELIA GOMES; BITTENCOURT, JACKSON CIONI; ADAMANTIDIS, ANTOINE. Melanin-concentrating hormone and sleep. CURRENT OPINION IN NEUROBIOLOGY, v. 44, p. 152-158, . (16/19845-9, 10/52068-0, 04/13849-5, 15/05990-4)

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