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Nitric oxide releasing hydrogels and vascular prosthesis for cardiovascular applications

Grant number: 22/14645-2
Support Opportunities:Research Projects - Thematic Grants
Duration: January 01, 2024 - December 31, 2028
Field of knowledge:Interdisciplinary Subjects
Convênio/Acordo: Netherlands Organisation for Scientific Research (NWO)
Principal Investigator:Marcelo Ganzarolli de Oliveira
Grantee:Marcelo Ganzarolli de Oliveira
Principal researcher abroad: Patricia Dankers
Institution abroad: Eindhoven University of Technology (TU/e), Netherlands
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Pesquisadores principais:
Amedea Barozzi Seabra ; Andrei Carvalho Sposito
Associated researchers:Ana Luíza Garcia Millás Massaguer ; Anthal Smits ; Julieta Irene Paez

Abstract

Acute and chronic coronary artery diseases are leading causes of deaths worldwide, demanding new advanced healthcare strategies to mitigate this risk, including the development of materials and inter/trans-disciplinary approaches to treat coronary artery occlusion or stenosis. Hence, the main aim of this project is the development of new polymeric biomaterials for applications in the field of cardiovascular regenerative medicine, including a) stimuli-responsive hydrogels capable of undergoing in situ gelation and promoting the dual delivery of proteins and nitric oxide as therapeutics after topical application, and b) photocurable and bioresorbable nitric oxide-releasing polyesters and hydrogels for the 3D printing of polymeric intracoronary stents and vascular prosthesis. The methodology will include the synthesis and characterization of the responsive polymeric materials and the evaluation of their efficacy and beneficial actions in vitro, in vivo and ex-vivo models. The consolidated experience of the research team, which combines backgrounds in chemistry, materials science, biomedical engineering, and medicine, will be crucial to achieving this goal. We envision that the proposed inter/trans-disciplinary approach and the new biomaterials to be developed will bring significant advances in the rapidly expanding field of regenerative cardiovascular applications, to either attenuate the lesions due to myocardial infarction (MI) or regenerate the damaged heart after MI. (AU)

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