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The role of celular prion protein in physiological and pathological processes II


The cellular prion protein has been receiving a lot of evidence in the literature not only because its involvement in prion diseases but also due to is biological relevance. Through it is important to note that our group is giving an important contribution in this last aspect. In our previous project we characterized 3 PrPc ligands: laminin and vitronectin at the extracellular matrix and STI1 at the cell surface. The cellular functions related with these interactions and part of the triggered cell signaling were also determined. These results point to a PrPc pleiotropic function probably through a macromolecular complex formed with its ligands. An important result obtained in our last project was the tinding of arare polymorphism at PRNP which is present in 23% of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Furthermore, patients with MTLE-HS showing this variant alIele had five fold greater chance of remaining intractable after temporal lobectomy. Thus, our results point to many events that must be approached in arder to map all the biological functions related to the celIular prion protein… (AU)

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El portero de las células 
Gatekeeper to the cells 
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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, TIAGO G.; SILVA, IARA R.; COSTA-SILVA, BRUNO; LEPIQUE, ANA PAULA; MARTINS, VILMA R.; LOPES, MARILENE H.. Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein. Stem Cells, v. 29, n. 7, p. 1126-1136, . (03/13189-2, 07/08410-2, 09/14027-2)
LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; MURAS, ANGELITA G.; MANCINI, GABRIEL L.; CASTRO, ROSA M. P. S.; RIBEIRO, KARINA C. B.; BRENTANI, RICARDO R.; LINDEN, RAFAEL; MARTINS, VILMA R.. Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. JOURNAL OF NEUROSCIENCE, v. 25, n. 49, p. 11330-11339, . (03/13189-2)
LIMA, FLAVIA R. S.; ARANTES, CAMILA P.; MURAS, ANGELITA G.; NOMIZO, REGINA; BRENTANI, RICARDO R.; MARTINS, VILMA R.. Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation. Journal of Neurochemistry, v. 103, n. 6, p. 2164-2176, . (03/13189-2)
ERLICH, RAFAEL B.; KAHN, SUZANA A.; LIMA, FLÁVIA R. S.; MURAS, ANGELITA G.; MARTINS, RODRIGO A. P.; LINDEN, RAFAEL; CHIARINI, LUCIANA B.; MARTINS, VILMA R.; MOURA NETO, VIVALDO. STI1 promotes glioma proliferation through AUPK and PI3K pathways. Glia, v. 55, n. 16, p. 1690-1698, . (03/13189-2)
LOBÃO-SOARES‚ B.; BIANCHIN‚ M.M.; LINHARES‚ M.N.; CARQUEJA‚ C.L.; TASCA‚ C.I.; SOUZA‚ M.; MARQUES‚ W.; BRENTANI‚ R.; MARTINS‚ V.R.; SAKAMOTO‚ A.C.; et al. Normal brain mitochondrial respiration in adult mice lacking cellular prion protein. Neuroscience Letters, v. 375, n. 3, p. 203-206, . (99/07124-8, 03/13189-2)
NICO‚ P.B.C.; LOBÃO-SOARES‚ B.; LANDEMBERGER‚ M.C.; MARQUES‚ W.; TASCA‚ C.I.; DE MELLO‚ C.F.; WALZ‚ R.; CARLOTTI‚ C.G.; BRENTANI‚ R.R.; SAKAMOTO‚ A.C.; et al. Impaired exercise capacity‚ but unaltered mitochondrial respiration in skeletal or cardiac muscle of mice lacking cellular prion protein. Neuroscience Letters, v. 388, n. 1, p. 21-26, . (03/13189-2)
LOBÃO-SOARES‚ B.; WALZ‚ R.; CARLOTTI JR‚ C.G.; SAKAMOTO‚ A.C.; CALVO‚ F.; TERZIAN‚ A.L.B.; SILVA‚ J.A.; WICHERT-ANA‚ L.; COIMBRA‚ N.C.; BIANCHIN‚ M.M.. Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice. Behavioural Brain Research, v. 183, n. 1, p. 87-94, . (03/13189-2)
MEOTTI‚ F.C.; CARQUEJA‚ C.L.; GADOTTI‚ V.M.; TASCA‚ C.I.; WALZ‚ R.; SANTOS‚ A.R.S.. Involvement of cellular prion protein in the nociceptive response in mice. Brain Research, v. 1151, p. 84-90, . (03/13189-2)
MAGLIO‚ L.E.; MARTINS‚ V.R.; IZQUIERDO‚ I.; RAMIREZ‚ O.A.. Role of cellular prion protein on LTP expression in aged mice. Brain Research, v. 1097, n. 1, p. 11-18, . (03/13189-2)
NICO‚ P.B.C.; DE-PARIS‚ F.; VINADÉ‚ E.R.; AMARAL‚ O.B.; ROCKENBACH‚ I.; SOARES‚ B.L.; GUARNIERI‚ R.; WICHERT-ANA‚ L.; CALVO‚ F.; WALZ‚ R.; et al. Altered behavioural response to acute stress in mice lacking cellular prion protein. Behavioural Brain Research, v. 162, n. 2, p. 173-181, . (03/13189-2)
ROMANO, SEBASTIAN A.; CORDEIRO, YRAIMA; LIMA, LUIS MAURICIO T. R.; LOPES, MARILENE H.; SILVA, JERSON L.; FOGUEL, DEBORA; LINDEN, RAFAEL. Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1. FASEB JOURNAL, v. 23, n. 12, p. 4308-4316, . (03/13189-2)
ARANTES, CAMILA; NOMIZ, REGINA; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; LIMA, FLAVIA R. S.; MARTINS, VILMA R.. Prion Protein and Its Ligand Stress Inducible Protein 1 Regulate Astrocyte Development. Glia, v. 57, n. 13, p. 1439-1449, . (03/13189-2)
COIMBRA‚ É.R.; REZEK‚ K.; ESCORSI-ROSSET‚ S.; LANDEMBERGER‚ M.C.; CASTRO‚ R.M.; VALADÃO‚ M.N.; GUARNIERI‚ R.; VELASCO‚ T.R.; TERRA-BUSTAMANTE‚ V.C.; BIANCHIN‚ M.M.; et al. Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. Epilepsy & Behavior, v. 8, n. 3, p. 635-642, . (03/13189-2)
COITINHO, ADRIANA S.; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; ROSSATO, JANINE I.; FREITAS, ADRIANA R.; CASTRO, CIBELE C.; CAMMAROTA, MARTIN; BRENTANI, RICARDO R.; IZQUIERDO, IVAN; MARTINS, VILMA R.. Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1. Neurobiology of Disease, v. 26, n. 1, p. 282-290, . (03/13189-2)

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