Research Grants 23/07458-4 - Periodontite, Biomarcadores - BV FAPESP
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Effect of Periodontitis treatment on the worsening of heart failure: a randomized clinical trial

Grant number: 23/07458-4
Support Opportunities:Regular Research Grants
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:José Roberto Cortelli
Grantee:José Roberto Cortelli
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade de Taubaté (UNITAU). Taubaté , SP, Brazil
Associated researchers: Davi Romeiro Aquino ; Gilson Fernandes Ruivo ; Marissol Fernandes Oliveira ; Ruy Felipe Melo Viégas ; Sheila Cavalca Cortelli

Abstract

Heart failure (HF) is a rapidly growing public health issue with an estimated prevalence of > 40 million individuals globally; while periodontitis affects 50% of people in general, and its most severe form affects approximately 11% of the population. The primary objective of this study is to evaluate the effect of periodontal therapy on blood levels of NT-proBNP at 3 and at 6 months. Secondary aims are the relation between biomarker blood levels and a) functional classes and b) its salivary levels. Antibodies against P. gingivalis besides species' levels will be also determined initially and at 3 and 6 months. As 44 participants must complete the study, 50 individuals over 35 years of age will be included and randomly assigned to dental scaling and root planing (n = 25 group) or control (n = 25). Blood, salivary, microbiological and immune examinations will be performed in addition to the periodontal treatment of scaling and root planning. Clinical data will be obtained both for initial diagnosis and disease staging and for longitudinal follow-up. NT-proBNP and antibodies against P. gingivalis will be evaluated by enzyme immunoassay using commercially available kits while P. gingivalis levels will be determined by quantitative polymerase chain reaction (qPCR). (AU)

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