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Development of innovative therapies and diagnostic tools for veterinary oncology

Abstract

The increase over the years in the number of people with cancer and cancer deaths, as well as the existence of cancers in different organs with heritable causes or not, are very similar to what happens in other animal species, especially those sharing the human environment as dogs and cats. In Brazil there are 55,1 and 24,7 million living dogs and cats respectively. Considering that 1 in 4 dogs develop cancer, there are almost 14 million living dogs that will develop cancer at some point in their lives. A big issue in veterinary oncology is the limited number of treatment options as well as early diagnosis and accurate tests. Therefore, the aim of this project will be the development of innovative therapies and molecular tests for improved cancer treatment in animals, addressing 5 scientific and technological challenges: (1) Development of high throughput screening (HTS) for comparative oncology studies and assessment of innovative cancer therapies; (2) Production of oncolytic recombinant NDV viruses for animal cancers; (3) Phase 1 clinical trial of Oncolytic NDV in tumor bearing dogs; (4) Development of NGS immunosequencing for use as liquid biopsy to monitor minimal residual disease in dogs with high-grade multicentric lymphoma and; (5) Development of a molecular panel for personalized cancer therapy in dogs. This proposal has top international and national associated researchers, and the requested resources are mostly for the acquisition of consumables and scholarships. (AU)

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