Development of applied multiplex electrochemical systems for detection of biomarkers related to cardiovascular diseases

Abstract

Multiplex electrochemical systems are technologies that allow the simultaneous detection of several biomarkers in a single biological sample, such as blood or urine, or the determination of the same compound with several electrodes, providing high data reproduction. In these systems, several electrodes can be prepared that can react in a specific way with the different biomarkers present in a specific sample, producing an electrochemical signal that can be measured and quantified. Biomarkers are substances that indicate the presence or progression of a disease. They can be proteins, enzymes, lipids, nucleic acids or metabolites, among others. The early and accurate detection of these biomarkers is essential for the diagnosis, prognosis and monitoring of several diseases, including cardiovascular ones. Cardiovascular diseases are illnesses that affect the heart and blood vessels, such as atherosclerosis, high blood pressure, acute myocardial infarction, arrhythmias and heart failure. The detection of specific biomarkers for these diseases can help in the early identification of symptoms, in the differential diagnosis and in monitoring the effectiveness of the treatment. Thus, the development of multiplex electrochemical systems for the detection of biomarkers related to cardiovascular diseases represents an important tool in diagnostic medicine, which can contribute to the prevention, treatment and control of these diseases. In this context, the present project aims at the development of platforms printed by serigraphy and 3D of multiplex systems, with up to 8 working electrodes for the detection of different analytes related to cardiovascular problems. (AU)