Development of polysaccharide membrane containing plant extract for pressure Ulcer treatment

Abstract

Pressure ulcers are injuries to the skin or tissue that usually occur as a result of other diseases that lead to the patient's loss of mobility, which is bedridden, leading to pressure in a specific area and decreased blood circulation. These lesions have different levels of depth of damage caused to the skin, which can affect muscles and bones. This problem causes serious pain, impairing the quality of life of patients in addition to increasing the mortality rate. In this context, it is essential that new formulations for topical use be developed for the prevention and treatment of pressure ulcers, aimed at relieving pain, preventing microbiological contamination, in addition to a more efficient and low-cost healing. Therefore, the present project proposes the development of a membrane for the healing of pressure ulcers, using carrageenan and açaí seed extract, natural raw materials with great healing potential, but little explored so far. In addition to this fact, silicone will be used in the formulation that allows it to adhere to the skin and not the wound, which promotes greater relief to the patient, in addition to containing an agent with antimicrobial activity, which will avoid microbiological contamination. This formulation will be developed with pain relief and functional effects in mind, increasing patient comfort. The developed membrane will be analyzed regarding its appearance, morphology, physicochemical and microbiological properties, mucoadhesiveness, cytotoxicity and healing potential. (AU)