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Multi-omic analysis of metabolism and microbiota of healthy and sick dogs and cats


The larger terminology concept defines multi-omics as the sum of information obtained by the "omics" sciences, at the same time the microbiome has been associated with health status and the risk of developing diseases. These points together suggest that the genetic richness of diverse microbial symbionts may play an extremely important role. In particular, the variation of metabolism and the microbiome can jointly encode essential results for health and fitness, that is, recent years of scientific research have demonstrated the importance of microorganisms in the health and disease of organisms, in addition, the recent The development of molecular techniques and the expansion of knowledge that provide metabolic information is also moving at an accelerated pace, thus allowing the sum of this information and the joint evaluation of the results obtained. In this way, based on the immense advance on the frontier of international knowledge, the objective of the present proposal is to explore, through this proposal, in a pioneering way, the multi-omic analysis of the metabolism and microbiome of healthy and sick dogs and cats, characterizing the fecal microbiota. , identifying genetic and metabolic variations through the "omics" sciences (lipidomics and metabolomics) and drawing multiple parallels between these two factors and other information such as body composition. Therefore, the project aims to explore three main themes, which encompass the main diseases that affect companion animals (obesity, chronic kidney disease and cancer), working with both species (dogs and cats) and therefore fragmenting the project into 6 sub-themes. for acting. The objective is still, possibly due to the originality and boldness of the proposals, to use the potential of animals as a model for human medicine and even allow the identification of new biomarkers of intra-species and inter-species disease. (AU)

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