Grant number: | 23/05450-6 |
Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
Principal Investigator: | Ademar Benévolo Lugão |
Grantee: | Ademar Benévolo Lugão |
Visiting researcher: | Slawomir Kadlubowski |
Visiting researcher institution: | Lodz University of Technology, Poland |
Host Institution: | Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil |
Abstract
Associate Professor Dr. Slawomir Kadlubowski will participate as a collaborator or advisor in 10 projects of the Center for Chemistry and Environment (CQMA) at the Nuclear and Energy Research Institute (IPEN), supporting their development. He is co-supervisor of the doctoral project entitled "Comparative study of different methodologies for the synthesis of nanogels as potential drug carriers" carried out in partnership between Brazil and Poland. In May 2019, the visiting researcher was in Brazil directing the development of nanogels using gamma irradiation by cobalt 60 source and high-energy electron beam and implementing protocols for the characterization of these structures by Static Light Scattering (SLS) in addition to assisting in characterizations additional nanogels. In 2018 and 2022 he received the student of this project in his laboratory for the development of PVP nanogels using an electron accelerator. This collaboration between the laboratories generated the scientific articles entitled "Synthesis of poly(N-vinyl pyrrolidone)(PVP) nanogels by gamma irradiation using different saturation atmospheres" and "An updated review of macro, micro, and nanostructured hydrogels for biomedical and pharmaceutical applications". Continuing the established partnership, on his new visit to Brazil, the visiting researcher will accompany the development of nanogels using ultraviolet (UV) radiation, an unprecedented study that could generate nanogels with unique characteristics, architecture and functionality, thus enabling new applications of this material in the pharmaceutical field. Additionally, he will support the development and characterization of hydrogels for application as dressings for burns and skin ulcers and the synthesis induced by ionizing radiation of papain-based nanocarriers. He will assist in the development of a new gold nanoparticle (AuNP) using human albumin (ASH) and epigallocatechin gallate (EGCG) and will assist in the development of mucoadhesive hydrogels for the administration of chemotherapy and/or immunotherapeutics containing gold nanoparticles coated with papain. Parallel to activities involving research projects, Dr. Slawomir Kadlubowski will also teach a short course entitled "Use of radiation in the development of nanostructures for health area" addressing the following topics: Radiation chemistry of polymers (Equations and calculations for synthesis of nanogels - planning, analysis of the results; crosslinking of a polymer in solution - Gx, Dg based on Mw and degradation of a polysaccharide - GS based on Mv or Mw for solid state and solution), Basic analytical methods to study polymers (molecular weight: viscometry, light scattering, GPC), Radiation synthesis , properties and applications of nanogels ( structure of macromolecules, hydrogels, nanohydrogel, interpolymer complexes, kinetics and synthesis, microgels and nanogels). He will participate in the doctoral defense as co-supervisor of the work entitled "Comparative study of different methodologies for the synthesis of nanogels as potential drug carriers" and will collaborate in the preparation of a postdoctoral research project to be developed in partnership between Brazil and Poland and entitled "Development of nanogels for the treatment of retinitis pigmentosa by gene therapy" for submission to national and international research support agencies. The PhD Kadlubowski is a professor at Lodz University of Technology at the Institute of Applied Radiation Chemistry with in-depth expertise in radiation chemistry and structural polymer modification and radiation processing of polymers, and specific expertise in the area of nanotechnology with a focus on the development and characterization of hydrogels and nanogels prepared with ionizing radiation. Such experience will provide excellent support in the development of the projects in which he will participate. (AU)
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