Local anesthetics effect on the metabolism of nervous cells in culture and in tissues, as evaluated by NMR-based metabolomics.

Abstract

Metabolomics study the quantitative changes in low molecular weight metabolites that occur in biological samples such as biofluids, cells and tissues. Nuclear Magnetic Resonance (NMR) and Mass spectroscopy are the two main techniques in metabolomic studies. This request is intended to find the financial support for a short-time visit (14 days - from October 8th to 21rst 2023) of Iola F. Duarte (Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, Portugal), an expert in NMR-based metabolomics to the Biomembranes group of University of Campinas (Unicamp) in order to: 1) Discuss previous NMR results, prepare publications and plan future research collaboration NMR-based metabolomics with the applicant (E.P); 2) give practical (hands-on) NMR-based metabolomics classes for graduate students of the "Molecular and Cellular Biophysics Techniques" course; 3) Give the lecture "Metabolomic insights into the metabolic interplay in the tumor microenvironment" in the seminars of the Dept of Biochemistry and Tissue Biology/Unicamp and at the "NMR-based metabolomics from cells to clinics" symposium, during the XLVII Annual Meeting of the Brazilian Biophysical Society (XLVII SBBf) at Unicamp Convention Center. (AU)