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The Antimicrobial Resistance Institute of São Paulo (The Aries Project)

Grant number: 21/10599-3
Support Opportunities:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: May 01, 2023 - April 30, 2028
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Arnaldo Lopes Colombo
Grantee:Arnaldo Lopes Colombo
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Pesquisadores principais:
Adriano Massuda ; Ana Cristina Gales ; Elbert Einstein Nehrer Macau ; Moacir de Miranda Oliveira Junior ; Nilton Erbet Lincopan Huenuman ; Sergio Schenkman
Associated researchers:Ademar Arthur Chioro dos Reis ; Aline Mariane de Faria ; Anete Pereira de Souza ; Antonio Carlos Campos Pignatari ; Camila Bertini Martins ; Carlos Magno Castelo Branco Fortaleza ; Christiane de Arruda Rodrigues ; Cláudia Sofia Frias Pinto ; Daielly Melina Nassif Mantovani ; Daniela Goncales Galasse Rando ; Décio Luis Semensatto Junior ; Elize Massard da Fonseca ; Fabio Augusto Faria ; Felipe Mendes Borini ; Flávia Cristina Martins Queiroz Mariano ; Gabriela de Brelaz ; Geórgia Christina Labuto Araújo ; Gustavo Henrique Goldman ; Iran Malavazi ; João Nóbrega de Almeida Júnior ; Katherine Keenan ; Leandro Augusto Calixto ; Lilian Berton ; Luiz Sidney Longo Junior ; Marcos Gonçalves Quiles ; Mirian Chieko Shinzato ; Patricia Sartorelli ; Rodrigo Cayô da Silva ; Simone Georges El Khouri Miraglia ; Suzan Pantaroto de Vasconcellos ; Wagner Luiz Batista ; Welington Luiz de Araújo
Associated scholarship(s):24/03612-1 - Evaluation of the role of the two-component system in the cell signaling of echinocandin resistant Candida glabrata, BP.PD
24/02476-7 - Exploring different statistical approaches to assess the relationship between microbial resistance and climate change in Brazil., BP.PD
24/02579-0 - Estimation of the Burden of Disease of Infections caused by Resistant Microbials in Brazil, BP.PD
+ associated scholarships 23/18292-0 - BiocinBR: Bacteriocin research platform to combat pathogens resistant to critical priority antimicrobials in Brazil, BP.DR
24/00892-3 - Investigation of the involvement of the VPS51 protein in the late complex and its role in drug resistance in Candida tropicalis, BP.DR
23/16216-4 - Genomic investigation of probiotics/bacteriocins for the treatment of antimicrobial-resistant pathogens, BP.PD
23/15368-5 - Frequency of pathogenic fungi isolates in recreational coastal water from the state of São Paulo (Pillar 2 - Project 4 - Work Package 5), BP.IC
23/16522-8 - Evaluation of the role of soil as a reservoir and dissemination of pathogenic fungi in surrounding areas of the main hospitals in the city of São Paulo, BP.IC
23/14561-6 - Differences among healthy, sick and MDR colonized patient's gut microbiome and the effect of Fecal Microbiota Transplantation as a therapeutic strategy to restore the gut microbiome., BP.PD
23/10416-1 - Use of the CRISPR-Cas12 methodology for the diagnosis of infectious bacteria in a hospital environment, BP.DR - associated scholarships


Antimicrobial resistance (AMR) has been considered one of the main threats to the human race in the 21st century. We are facing an unstoppable fast-forward instance of Darwinian adaptation through natural selection, in which microbes are constantly evolving to survive antimicrobials. As part of their natural behavior, they adapt continuously. They will succeed unless we develop effective approaches to control and prevent further AMR spread. We propose to establish the Antimicrobial Resistance Institute of São Paulo (ARIES) that will join researchers from 5 universities in São Paulo with experts from public organizations (EMBRAPA, CETESB) and representatives of the Ministry of Agriculture, Livestock and Food Supply, Ministry of Health, Brazilian Health Regulatory Agency (ANVISA) and Pan American Health Organization (PAHO). Working together in a pioneering enterprise, they will fight against AMR implementing the concepts of Global Health and One Health. Mitigation of the AMR threat requires a multidisciplinary approach that recognizes and interferes in the drivers of AMR in the human-animal-environment interface. ARIES will count on five main pillars to achieve our key objectives: 1) Socio-Environmental Observatory and Data Science Center: surveillance of ecosystems involved in the emergence and spread of AMR; 2) Characterization of microbial evolution, mechanisms of AMR and microorganism fitness and pathogenicity; 3) Development and validation of new strategies for control and prevention of AMR in humans, animals, and environment; 4) Translation of the successful initiatives to Business and Public Health Policies; and 5) Diffusion of ARIES - Knowledge in connection with Society, Education and Dissemination. ARIES will not only contribute to elaborate a more sophisticated and comprehensive surveillance system able to early detect the emergence of AMR in the context of One Health, but also generate new strategies to respond, contain, and prevent the resistant infections across healthcare settings, food, and communities. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAES, TACIANA G. S.; BARROS, LUCELIA A.; SILVA, RICARDO SANTOS; GONZALEZ, MARIO H.; CARRILHO, ELMA N. V. M.; LABUTO, GEORGIA. Synthesis and characterization of biochars modified with natural deep eutectic solvent (NADES) for dipyrone removal from aqueous medium. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 35, p. 18-pg., . (22/06823-8, 21/06471-1, 21/14759-5, 21/14791-6, 20/12263-0, 21/10599-3, 20/14419-7, 22/08358-0)

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