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Local and systemic effects of radiopacifiers from reparative dental materials


Endodontic reparative materials use radiopacifiers containing metals in their composition allowing follow-up examination through imageology. These materials have different levels of solubility due to their hydraulic characteristic and a crucial concern is that a local migration of radiopacifying elements to the adjacent tissues from these materials has been reported to dentine and connective tissue. However, no study has considered the potential influence of leachates derived from radiopacifying agents after the use of these materials on the elemental systemic levels. The aim of this study is to evaluate - including the materials characterization, in vitro effects on cell cultures and in vivo effects in an animal model (Wistar rats) with subcutaneous and bone implantation - the use of reparative materials containing radiopacifiers based on bismuth, tantalum, tungsten, and zirconium. In addition, two experimental formulations containing alternative radiopacifiers will be evaluated in relation to systemic migration. All methodologies will be compared with pure tricalcium silicate without the addition of radiopacifier and, for the in vivo tests, negative control animals will serve for comparisons without any implantation procedure. It is expected with the present proposal to point out a composition of radiopacified endodontic repair material as inert as possible and systemically safe, inhibiting the systemic migration and accumulation. The establishment of the number of samples was obtained through sample size calculation for each quantitative test and the results obtained will be statistically analysed for normality to obtain the multiple comparisons. (AU)

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