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Continuous improvement of vaccines: Center for Viral Surveillance and Serological Assessment (CeVIVAS)

Grant number: 21/11944-6
Support Opportunities:Research Grants - Science Centers for Development
Duration: June 01, 2022 - May 31, 2027
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Sandra Coccuzzo Sampaio Vessoni
Grantee:Sandra Coccuzzo Sampaio Vessoni
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
Daniel Carvalho Pimenta ; Eliana Faquim de Lima Mauro ; Geraldo Santana Magalhães ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Simone Kashima Haddad
Associated researchers:Alex Ranieri Jerônimo Lima ; Claudia Renata dos Santos Barros ; Daniel José Galafasse Lahr ; David Schlesinger ; Dimas Tadeu Covas ; Elaine Cristina Marqueze ; Evaldo Stanislau Affonso de Araujo ; Evandra Strazza Rodrigues Sandoval ; Heidge Fukumasu ; Hugo Aguirre Armelin ; Igor Cabral Corrêa ; Jayme Augusto de Souza-Neto ; Joao Paulo Fumio Whitaker Kitajima ; Jose Salvatore Leister Patane ; Jounghyeok Kwon ; Julia Pinheiro Chagas da Cunha ; Keith Crandall ; Luiz Carlos Junior Alcantara ; Luiz Lehmann Coutinho ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Marta Giovanetti ; Maurício Lacerda Nogueira ; Nancy Starobinas ; Rejane Maria Tommasini Grotto ; Svetoslav Nanev Slavov ; Vincent Louis Viala
Associated scholarship(s):24/03645-7 - Identification and sequencing of peptides derived from the hypervariable region of vaccination-induced antibodies, BP.PD
23/15913-3 - Bioinformatics in the phylogenetic, phylogeographic, and epidemiological analysis of the evolution of Influenza viruses in Brazil, BP.TT
23/13992-3 - Implementation of a platform for analyzing the cellular immunity induced by immunizers produced by the Butantan Institute: Protective cellular immunity in response to viral infections, BP.PD
+ associated scholarships 23/14852-0 - Impact of different dengue genotypes on the pathophysiology and severity of the disease: a multi-omics approach to the disease and which biological factors lead to its worsening., BP.DR
23/07688-0 - Comparative phylogenetics, phylogeography and epidemiology applied in understanding the evolution of COVID-19, Influenza, and Dengue viruses in Brazil, BP.PD
23/08965-7 - Genomic surveillance of Influenza A and B viruses circulating in the city of São Paulo between 2023 and 2025, BP.DR
23/11920-5 - Development of a pipeline for continuous improvement of monoclonal antibodies for therapeutic use in diseases caused by influenza and SARS-CoV-2., BP.PD
23/11334-9 - Production of pseudoviral particles to evaluate neutralizing antibodies, BP.PD
23/09546-8 - Development of Biosensor for Rapid Diagnosis of Dengue Serotypes, BP.TT
22/16349-1 - Genomic surveillance and viral quasispecies reconstruction of dengue virus in an endemic region, BP.DR - associated scholarships


Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many factors, such as the individual's characteristics, demographic and immunological matters, and the circulating pathogens. Instituto Butantan evidenced its potential for rapid response during the COVID-19 pandemic, when its Scientific Development Center faced the challenges with technical adequacies and management training to integrate scientific and administrative sectors, such as the Municipal and State Health Departments. Based on this successful experience, this project aims to monitor some of these factors to obtain a continuous improvement of viral vaccines for Influenza, COVID-19, and Dengue. To that end, we begin with constant genomic surveillance of the circulating Influenza, SARS-CoV-2, and DENV viruses in the State of São Paulo, in the country, and neighboring countries. The data obtained will allow (i) studies on the evolutionary history of these viruses and (ii) knowing the viral variants circulating in the studied regions. To know the protective capacity of the vaccines used, we will investigate whether (i) sera from vaccinated individuals neutralize the infection of circulating variants and (ii) how is the cellular response of vaccinated individuals against the viral strain used in the immunization and against the variants circulating in the population. This work will allow the creation of a biobank of viral variants, a library of vaccinated individuals, and a bank of mononuclear cells isolated from the peripheral blood of vaccinated individuals that can also be used in future projects. In parallel, we will analyze the effectiveness of vaccines according to sociodemographic, health, and environmental data, comparing the effectiveness of vaccines according to viral variants. The results obtained will be continuously sent to bodies in the three administrative branches: municipal, state, and federal spheres, to contribute significantly to the decision-making of public policies. As a result, we will continuously provide data to the health system so it can face the challenges posed by the viruses studied herein with subsidies more rigorous than before. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Butantan’s dengue vaccine is 80% effective 
La vacuna contra el dengue producida en Brasil por el Instituto Butantan de São Paulo posee una eficacia del 80 % 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAVALCANTE SOUZA, JULIANA VANESSA; SANTOS, HAZERRAL DE OLIVEIRA; LEITE, ANDERSON BRANDAO; GIOVANETTI, MARTA; BEZERRA, RAFAEL DOS SANTOS; DE CARVALHO, ENEAS; TODAO BERNARDINO, JARDELINA DE SOUZA; VIALA, VINCENT LOUIS; HADDAD, RODRIGO; CICCOZZI, MASSIMO; et al. Viral Metagenomics for the Identification of Emerging Infections in Clinical Samples with Inconclusive Dengue, Zika, and Chikungunya Viral Amplification. Viruses-Basel, v. 14, n. 9, p. 8-pg., . (17/23205-8, 18/15826-5, 21/09446-8, 21/11944-6, 20/13194-1, 19/08528-0)
VAZQUEZ, CYNTHIA; ALCANTARA, LUIZ CARLOS JUNIOR; FONSECA, VAGNER; LIMA, MAURICIO; XAVIER, JOILSON; ADELINO, TALITA; FRITSCH, HEGGER; CASTRO, EMERSON; DE OLIVEIRA, CARLA; SCHUAB, GABRIEL; et al. Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay. Viruses-Basel, v. 15, n. 6, p. 14-pg., . (21/11944-6)
SLAVOV, SVETOSLAV NANEV; LIMA DE LA-ROQUE, DEBORA GLENDA; MENDES DA COSTA, PERICLES NATAN; RODRIGUES, EVANDRA STRAZZA; SANTOS, ELAINE VIEIRA; BORGES, JOSIANE SERRANO; EVARISTO, MARIANE; MACONETTO, JULIANA DE MATOS; MARQUES, ADRIANA APARECIDA; MILHOMENS, JONATHAN; et al. Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil. Viruses-Basel, v. 14, n. 10, p. 12-pg., . (14/50947-7, 18/15826-5, 20/10127-1, 20/06441-2, 19/22155-2, 17/26950-6, 21/11944-6, 13/08135-2)
GIOVANETTI, MARTA; VAZQUEZ, CYNTHIA; LIMA, MAURICIO; CASTRO, EMERSON; ROJAS, ANALIA; FUENTE, ANDREA GOMEZ DE LA; AQUINO, CAROLINA; CANTERO, CESAR; FLEITAS, FATIMA; TORALES, JUAN; et al. Rapid Epidemic Expansion of Chikungunya Virus East/Central/ South African Lineage, Paraguay. Emerging Infectious Diseases, v. 29, n. 9, p. 5-pg., . (21/11944-6)

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