Serological survey for SARS-CoV-2 and viral detection in children with chronic kidney disease in renal replacement therapy and kidney transplantation

Abstract

Chronic Kidney Disease (CKD) is characterized by slow, progressive and irreversible loss of kidney functions. With End Stage Renal Disease (ESRD) installed, the kidney no longer performs its metabolic, endocrine and excretion functions, which leads the patient to uremic condition and the need for a method of Renal Replacement Therapy (RRT). Among the RRT methods currently available, we have dialysis (hemodialysis and peritoneal dialysis) in addition to kidney transplantation. Despite the innumerable advances in Renal Replacement Therapy and in the care of this population, patients can present several complications, such as cardiovascular, metabolic and infectious by bacteria, viruses and fungus. In recent years, some studies have demonstrated the detection of several herpesviruses in the saliva of patients with ESRD and in kidney transplant recipients. With the emergence of the pandemic caused by SARS-CoV-2, it became urgent to understand its pathophysiology and interaction with other pathogens in different clinical situations, especially in those individuals who have risk factors for COVID-19. However, a gap is identified in the literature, since there are no published studies that elucidate the occurrence of infection and the oral excretion of human herpesviruses and the new Coronavirus in the child population in RRT. Therefore, it's necessary to study these phenomena and relate them to the clinical variables related to RRT, in order to characterize the risk factors and protective factors for such an occurrence. This is an observational, longitudinal, prospective, analytical, cohort study, which will be developed with the population of chronic kidney in RRT in the Pediatric Nephrology Service of São Paulo Hospital, of Federal University of São Paulo (UNIFESP). (AU)