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Tailoring colloids through supramolecular interactions: from fundamentals to applications

Grant number: 21/12071-6
Support Opportunities:Research Projects - Thematic Grants
Duration: July 01, 2022 - June 30, 2027
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Watson Loh
Grantee:Watson Loh
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Pesquisadores principais:
Camila Alves de Rezende ; Edvaldo Sabadini ; Fernando Carlos Giacomelli ; Maria Isabel Felisberti ; Mateus Borba Cardoso
Associated researchers:Caio Gomide Otoni ; Emily Cranston ; Francois Genès Tournilhac ; Jorge Fernando Jordão Coelho ; Maria Vamvakaki ; Orlando Jose Rojas Gaona ; Srinivasa Raghavan
Associated grant(s):24/01646-6 - Collaboration on the study if polyelectrolyte complexes, AV.EXT
23/14830-7 - In situ flow SAXS characterization of surfactant aggregates through the digestive process, AP.R SPRINT
23/06435-0 - Discussions on rheology and structure in surfactant aggregates, AV.EXT
23/01427-0 - Vitrimers based on acrylic and vinylic polymers crosslinked via dynamic ester and amide bonds: development, processing, formulation and recycling, AP.R
23/01620-4 - Sustainable technologies for the artwork conservation based on cellulose and lignin nanomaterials, AP.R
23/00919-6 - Thermodynamic modeling of the formation of giant micelles, AP.R
22/14113-0 - Multi-user equipment approved in grant 2021/ 12071-6: Masuko Grinder (shear mill and rotary micro pulverizer), AP.EMU
22/14066-2 - Multiuser equipment approved in grant 21/12076-1: Quartz Crystal Microbalance with Dissipation (QCM-D), AP.EMU - associated grants
Associated scholarship(s):24/01827-0 - Magnitudes of thermodynamic forces that result in the formation of giant micelles, BP.IC
24/00101-6 - Micro and nanoplastics under photodegradation conditions: interactions with persistent organic pollutants, cells and bacteria in a synchrotron approach, BP.DR
23/13208-0 - Nano-bio interactions between silica nanoparticles and biologically relevant proteins: scientific and technological contributions based on the use of synchrotron research, BP.DR
+ associated scholarships 23/14838-8 - Nanocellulose-based hydrogels for cleaning surfaces of artworks, BP.MS
23/10643-8 - Multicompartmentalized hydrogels as models of functional prototissues, BP.PD
23/08883-0 - Enzyme encapsulation strategies using coacervates in the nanometric domain, BP.IC
23/07122-6 - Cellulose nanocrystals and nanofibrils grafted with poly(2-alkyl-oxazolines), BP.DD
23/07740-1 - Compact polyelectrolyte complexes from polysaccharidic precursors, BP.DD
23/06914-6 - Vitrimerization of Renewable Macromolecules and Nanoparticles: Bio-Based Materials Assembled via Dynamic Covalent Chemistry, BP.PD
23/02144-1 - Dynamics of silica nanoparticles in complex biological fluids through the XPCS technique, BP.PD
22/14668-2 - Engineering polymersomes of selective permeability towards nanoreactors for biocatalysis, BP.PD
23/00103-6 - Deciphering the cellular destiny of silica nanoparticles in human cells by X-ray nanotomography, BP.DD
22/13895-5 - Complex coacervate core micelles and polyelectrolyte complexes for gene therapies: unrevealing thermodynamics and structural features, optimizing biological responses, BP.PD
22/13395-2 - Surface Engineering of Gold Sols towards the Control over Protein Corona Features, BP.PD
22/11455-8 - Magnetic Drawing for the Optimized Production of Artifical Polymeric Cilia, BP.IC
22/05465-0 - Reprocessable and natural polymeric networks based on dynamic covalent bonds between cellulose nanofibers, BP.DR
22/08780-4 - Swimming supraparticles: controlling the motility of nanocellulose/yeast supraparticles through surface chemistry, BP.IC
22/09381-6 - Experimental techniques for research in colloids: small angle X-ray scattering, QCM-D for adsorption and assessment of colloidal stability, BP.TT - associated scholarships


This project aims at achieving controlled association of varied colloids through either hydrophobic, electrostatic, or covalent bonds (or their combination) to tailor their characteristics, preferably in a reversible fashion. The envisaged functional colloidal objects span from surfactant and/or polymer aggregates, to nanoparticles of inorganic nature (mostly silica) or derived from renewable nanomaterials such as nanocelluloses, nanolignins, and nanochitins. The processes to be investigated include the preparation of polymer/surfactant aggregates for encapsulation of biomolecules and model drugs, preparation of nanomaterials under confinement, rheological control of fluids, model systems for bioactive materials, responsive polymers, and multiscale association materials. In summary, we are proposing a series of studies to be jointly developed by a group of researchers of wide expertise, with the common focus on understanding how colloidal systems may be tailored to achieve new properties and functionalities. (AU)

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PERIN, GIOVANNI B. B.; FELISBERTI, MARIA I. I.. Polyesters Inspired by Glycerides: Enzymatic Polycondensation, Structure, Properties, and Nanoparticle Preparation. MACROMOLECULES, v. 56, n. 17, p. 10-pg., . (21/12071-6, 15/25406-5)
FERREIRA, LARISSA FERNANDA; PICCO, AGUSTIN SILVIO; GALDINO, FLAVIA ELISA; CALUMBY ALBUQUERQUE, LINDOMAR JOSE; BERRET, JEAN-FRANCOIS; CARDOSO, MATEUS BORBA. Nanoparticle-Protein Interaction: Demystifying the Correlation between Protein Corona and Aggregation Phenomena. ACS APPLIED MATERIALS & INTERFACES, v. 14, n. 25, p. 11-pg., . (17/02145-7, 18/09555-9, 21/12071-6, 20/00767-3, 14/21910-8, 19/24894-7, 15/25406-5)
MATTOS, BRUNO D. D.; ZHU, YA; TARDY, BLAISE L. L.; BEAUMONT, MARCO; RIBEIRO, ANA CAROLINA R.; MISSIO, ANDRE L.; OTONI, CAIO G. G.; ROJAS, ORLANDO J. J.. Versatile Assembly of Metal-Phenolic Network Foams Enabled by Tannin-Cellulose Nanofibers. Advanced Materials, v. N/A, p. 10-pg., . (21/12071-6)
RIBEIRO, IRIS RENATA SOUSA; DA SILVA, RAQUEL FRENEDOSO; RABELO, RENATA SANTOS; MARIN, TALITA MIGUEL; BETTINI, JEFFERSON; CARDOSO, MATEUS BORBA. Flowing through Gastrointestinal Barriers with Model Nanoparticles: From Complex Fluids to Model Human Intestinal Epithelium Permeation. ACS APPLIED MATERIALS & INTERFACES, v. 15, n. 30, p. 11-pg., . (21/12071-6, 15/25406-5, 17/21318-0)
SILVA, SIMONE S.; RODRIGUES, LUISA C.; FERNANDES, EMANUEL M.; DA COSTA, DIANA SOARES; VILLALVA, DENISE G.; LOH, WATSON; REIS, RUI L.. Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach. MARINE DRUGS, v. 21, n. 7, p. 15-pg., . (19/12665-3, 21/12071-6, 15/25406-5, 18/08045-7)
DU, HAIQIN; KALEM, SANDRA; HUIN, CECILE; ILLY, NICOLAS; TRESSET, GUILLAUME; GIACOMELLI, FERNANDO CARLOS; GUEGAN, PHILIPPE. Engineering of ion permeable planar membranes and polymersomes based on p-cyclodextrin-cored star copolymers. Journal of Colloid and Interface Science, v. 630, p. 12-pg., . (21/12071-6, 19/06634-8)
BATISTA, CARIN C. S.; PANICO, KARINE; TROUSIL, JIRI; JANOUSKOVA, OLGA; CASTRO, CARLOS EDUARDO DE; STEPANEK, PETR; GIACOMELLI, FERNANDO C.. Protein coronas coating polymer-stabilized silver nanocolloids attenuate cytotoxicity with minor effects on antimicrobial performance. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 218, p. 11-pg., . (19/06634-8, 21/12071-6, 17/24603-7, 19/03223-7)
GIONA, RENATA MELLO; VITORAZI, LETICIA; LOH, WATSON. Assessing the Contribution of the Neutral Blocks in DNA/Block-Copolymer Polyplexes: Poly(acrylamide) vs. Poly(ethylene Oxide). Molecules, v. 28, n. 1, p. 16-pg., . (10/00528-7, 21/12071-6, 15/25406-5)
MISSIO, ANDRE LUIZ; OTONI, CAIO G.; ZHAO, BIN; BEAUMONT, MARCO; KHAKALO, ALEXEY; KAEMAERAEINEN, TERO; SILVA, SILVIA H. F.; MATTOS, BRUNO D.; ROJAS, ORLANDO J.. Nanocellulose Removes the Need for Chemical Crosslinking in Tannin-Based Rigid Foams and Enhances Their Strength and Fire Retardancy. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 10, n. 31, p. 8-pg., . (21/12071-6)
DE OLIVEIRA, FERNANDO A.; ALBUQUERQUE, LINDOMAR J. C.; NASCIMENTO-SALES, MICHELLE; CHRISTOFFOLETE, MARCELO A.; BELLETTINI, ISMAEL C.; GIACOMELLI, FERNANDO C.. Balancing gene transfection and cytotoxicity of nucleic acid carriers with focus on ocular and hepatic disorders: evaluation of hydrophobic and hydrophilic polyethyleneimine derivatives. JOURNAL OF MATERIALS CHEMISTRY B, v. 11, n. 20, p. 16-pg., . (19/20470-8, 21/12071-6, 19/12944-0)
PERIN, GIOVANNI B.; FELISBERTI, MARIA I.. Phosphorylated Polyesters Inspired by Phospholipids: Synthesis, Characterization, and Potential Applications. Biomacromolecules, v. N/A, p. 12-pg., . (18/01562-6, 21/12071-6, 15/25406-5)
BOUCHMELLA, KARIM; LION, QUENTIN; GERVAIS, CHRISTEL; CARDOSO, MATEUS BORBA. Impact of Mesoporous Silica Functionalization Fine-Tuning on Antibiotic Uptake/Delivery and Bactericidal Activity. ACS OMEGA, v. 8, n. 13, p. 11-pg., . (21/12071-6, 15/25406-5, 14/22322-2)
YONEDA, JULIANA SAKAMOTO; CARDOSO, MATEUS BORBA. Nanoparticle-induced conformational changes in protein corona revealed by circular dichroism spectroscopy. Nanomedicine, v. 18, n. 9, p. 3-pg., . (21/12071-6)
SANTOS, MADSON R. E.; FIDELIS, CLARA L. B.; ZANDONADI, FLAVIA S.; GIACOMELLI, FERNANDO C.; FELISBERTI, MARIA ISABEL. Amphiphilic star copolymers composed of curcumin core for bacterial inactivation. Polymer International, v. N/A, p. 9-pg., . (20/15923-0, 21/12071-6, 15/25406-5)
DE OLIVEIRA, FERNANDO A.; DA SILVA BATISTA, CARIN CRISTINA; CERNOCH, PETER; SINCARI, VLADIMIR; JAGER, ALESSANDRO; JAGER, ELIEZER; GIACOMELLI, FERNANDO C.. Role of Membrane Features on the Permeability Behavior of Polymersomes and the Potential Impacts on Drug Encapsulation and Release. Biomacromolecules, v. N/A, p. 10-pg., . (21/12071-6, 19/06634-8, 19/12944-0)
DE OLIVEIRA, FERNANDO A.; BATISTA, CARIN C. S.; ALBUQUERQUE, LINDOMAR J. C.; CERNOCH, PETER; STEINHART, MILOS; SINCARI, VLADIMIR; JAGER, ALESSANDRO; JAGER, ELIEZER; GIACOMELLI, FERNANDO C.. Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing. Journal of Colloid and Interface Science, v. 635, p. 11-pg., . (17/24603-7, 16/23844-8, 19/12944-0, 19/06634-8, 21/12071-6)

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