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Development of subunit vaccines against SARS-CoV-2 based on the receptor binding domain (RBD)

Abstract

Coronavirus 2019 Disease (COVID-19) caused by SARS-CoV-2 reached a pandemic character in early 2020. According to the World Health Organization, SARS-CoV2 infection presents mild to moderate symptoms in 81% of cases, however, it can progress to severe cases leading to severe acute respiratory syndrome and death. Virus entry into host cells is mediated by Spike, a densely glycosylated protein present in the envelope of SARS-CoV-2, which interacts with the angiotensin-2 converting enzyme (ACE-2) receptor, thus promoting membrane fusion. Studies have shown that the Receptor Binding Domain (RBD), present in the Spike, is responsible for binding to the ACE-2 receptor. Antibodies specific to the RBD region have neutralizing activity and are therefore considered promising vaccine candidates. The main goal of this project is the preclinical study of recombinant proteins representing the RBD in the presence of different adjuvants. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS LUNARDELLI, VICTORIA ALVES; APOSTOLICO, JULIANA DE SOUZA; SANTOS SOUZA, HIGO FERNANDO; COIRADA, FERNANDA CAROLINE; MARTINHO, JESSICA AMARAL; ASTRAY, RENATO MANCINI; BOSCARDIN, SILVIA BEATRIZ; ROSA, DANIELA SANTORO. ZIKV-envelope proteins induce specific humoral and cellular immunity in distinct mice strains. SCIENTIFIC REPORTS, v. 12, n. 1, p. 13-pg., . (18/05320-7, 17/17471-7, 21/13004-0)
LUNARDELLI, VICTORIA ALVES SANTOS; ALMEIDA, BIANCA DA SILVA; APOSTOLICO, JULIANA DE SOUZA; REZENDE, THAIS; YAMAMOTO, MARCIO MASSAO; PEREIRA, SAMUEL SANTOS; BUENO, MARIA FERNANDA CAMPAGNARI; PEREIRA, LENNON RAMOS; CARVALHO, KARINA INACIO; SLHESSARENKO, RENATA DEZENGRINI; et al. Diagnostic and vaccine potential of Zika virus envelope protein (E) derivates produced in bacterial and insect cells. FRONTIERS IN IMMUNOLOGY, v. 14, p. 14-pg., . (21/13004-0, 17/17471-7)

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