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Investigation of reactive intermediates in complex chemical and biochemical processes


This proposal aims to expand the scope of the reactive systems evaluated by our research group (organo- and metal-based chiral catalysis) to including more complex reactive systems as polymerization reactions and the formation of drug metabolites and degradation products. To achieve these goals, the infrared ion spectroscopy (IRMPD spectroscopy) technique developed in the framework of the JP1 (2014/15962-5) and the advanced sample methods developed during the FAPESP research project (2019/25634-9) will be applied and enhanced by their synergic use with Ion Mobility Spectrometry (IMS), constituting the state-of-the-art IMS-IRMPD-MS platform for the study of convoluted reaction systems in complex matrices. These techniques would allow the differentiation of isomers in, virtually, any chemical system, enhancing the quality and scope of our research and allowing the access of external users to these state-of-the-art techniques by developing a multiuser instrument as successfully implemented during the JP1 project. This instrumentation will be used to study: I) the first steps of polybenzoxazine formation; II) the polymerization motifs of polyaniline; III) the oxidation products of the drug metoprolol and IV) the degradation products of chemotherapy agents cyclophosphamide and ifosfamide. Besides evaluating these relevant chemical species, this project will allow the production of qualified professionals for the mass spectrometry community and the development of a state-of-the-art technique that will be made available for research institutions and the private sectors. (AU)

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