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Inventorying secondary metabolism applying metabolomic strategies: contribution to the Brazilian biodiversity valuation

Grant number: 20/02207-5
Support type:BIOTA-FAPESP Program - Thematic Grants
Duration: December 01, 2021 - November 30, 2026
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Norberto Peporine Lopes
Grantee:Norberto Peporine Lopes
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Paulo Cézar Vieira
Assoc. researchers: Alan William Meerow ; Andrés Eduardo Brunetti ; Andrés Sergio Moreira Muñoz ; Antonio Campos Rocha Neto ; Célio Fernando Baptista Haddad ; Diego German Gutierrez ; Giuliano Cesar Clososki ; Guilherme Corrêa de Oliveira ; Ingrid Koch ; Jennifer Mandel ; Jimi Naoki Nakajima ; João Luis Callegari Lopes ; Juliana Massimino Feres ; Leticia Veras Costa Lotufo ; Marcelo Monge Egea ; Mariana Andrea Grossi ; Mariana Lúcio Lyra ; Pieter C Dorrestein ; Rafael Borges da Silva Valadares ; Ricardo Roberto da Silva ; Ricardo Vessecchi Lourenço ; Thais Guaratini ; Túlio Marcos Nunes


Plants and living organisms emit, detect and respond to chemical stimuli, thus creating an almost unlimited number of interactions through chemical signals. Most of these molecules are classified as secondary metabolites and are an important area of research in our country. Technological and intellectual advances in the last two decades have allowed the development of analyzes of natural products at various molecular levels, including molecular diversity and taxonomy, chemical ecology, understanding of circadian rhythms, among others. These advances have also deepened our understanding of nature to encompass interactions at various levels of organisms at different rates. Mass spectrometry instruments are important tools for investigating the incredibly diverse chemistry that is associated with these biological systems. Our ability to inventory this chemistry, using modern tools, has increased our understanding of the function of secondary metabolism. In this project, we intend to develop computer and spectrometry strategies in the universal analysis of small molecules, seeking to establish a comprehensive understanding of natural products in different biological models and seeking to add value to these substances through pharmacological evaluation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRUNETTI, ANDRES E.; BUNK, BOYKE; LYRA, MARIANA L.; FUZO, CARLOS A.; MARANI, MARIELA M.; SPROEER, CATHRIN; HADDAD, CELIO F. B.; LOPES, NORBERTO P.; OVERMANN, JOERG. olecular basis of a bacterial-amphibian symbiosis revealed by comparative genomics, modeling, and functional testin. ISME Journal, v. 16, n. 3 OCT 2021. Web of Science Citations: 1.

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