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Multi-user equipment approved in grant 2017/08684-7: BRET

Grant number: 21/06607-0
Support Opportunities:Multi-user Equipment Program
Duration: September 01, 2021 - August 31, 2028
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Principal Investigator:Célia Regina da Silva Garcia
Grantee:Célia Regina da Silva Garcia
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials, AP.TEM
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment:Processos Biológicos - Caracterização - Leitores de fluorescência (imageamento, placas)
Caracterização de Materiais - Microscopia ótica - Fluorescência
Manufacturer: Fabricante não informado
Model: Modelo não informado

Abstract

Malaria stands as the third most dangerous infectious disease after HIV/AIDS and tuberculosis that afflict mankind. The last decade studies pointed that pathogen have developed sophisticated cell signaling networks that allow for both cell-cell communication as well as sensing the external environment. In this direction, single cell protozoan parasites have to develop systems to withstand relatively large alterations in their external environments, including existing in the mammalian host with complex defense systems. In addition to depicting a complex biology, with a sexual and asexual developmental stage, malaria parasite, is exposed to distinct microenvironments within the vector cycle as well as during its development inside a vertebrate. The overall objective of this project is to understand how the parasite detects signaling from its milieu, what are the molecular components involved in transducing this signaling. We recently reported that purinergic signaling could be involved in TNF perception by P. falciparum. We plan to dissect the involvement of purinergic receptor signaling in P. falciparum cell cycle thus unraveling what is the participation of a P2X7 receptor in TNF signaling. We will use the PfGCaMP3 parasites as well as other molecular and cellular tools to understand signaling pathways in malaria parasite aiming to disrupt this signaling. (AU)

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