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Physiopathology of CO2 sensitivity: role of locus coeruleus

Grant number: 20/01702-2
Support Opportunities:Research Projects - Thematic Grants
Duration: October 01, 2021 - September 30, 2026
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Luciane Helena Gargaglioni Batalhão
Grantee:Luciane Helena Gargaglioni Batalhão
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated researchers: Antonio Egidio Nardi ; Bryan Eric Strauss ; Daniel Penteado Martins Dias ; Hélio Zangrossi Júnior ; Lynn Kristine Hartzler ; Patricia Jensen ; Raphael Escorsim Szawka ; Richard Kinkead
Associated grant(s):21/13364-7 - Multi-user equipment approved in grant 2020/01702-2: electrophysiological research microscope, AP.EMU
Associated scholarship(s):23/07978-8 - The involvement of microglia in the locus coeruleus (LC) in the sleep-wake cycle and in the respiratory and behavioral response to panicogenic stimuli, BP.MS
23/09207-9 - Locus coeruleus and CO2/pH chemosensitivity in mice: evaluation during development, sleep/wake cycle and arousal respons, BP.DR
22/08430-3 - Effect of estrous cycle on paniconegic response to CO2 in mice., BP.IC
+ associated scholarships 22/11232-9 - Physiopathology of CO2 sensitivity: role of locus coeruleus, BP.TT
21/08968-0 - Behavioral and neuroinflammatory effects caused by a simulated poverty model in mice: implications for panic disorder, BP.PD
22/05057-0 - Contribution of Locus Coeruleus (LC) glial cells in the cardiorespiratory response to hypercapnia and in the manifestation of CO2-induced panic attacks, BP.PD
21/13618-9 - Participation of calcium-activated potassium channels in respiratory, autonomic and behavioral responses to CO2/pH and in the chemosensitivity of LC neurons, BP.PD - associated scholarships


The locus coeruleus (LC) is a sexually dimorphic noradrenergic nucleus that projects throughout the brain and is the main source of central norepinephrine controlling various functions, including central chemoreception. Our group was a pioneer in demonstrating the importance of LC in ventilatory responses to CO2/pH changes in males and females and that the gain of LC neurons depends on age, being larger in young (P10) neonates. It is well known that the imbalance in noradrenergic neurotransmission modulation in this area is implicated in the emergence of numerous psychiatric disorders, including panic disorder. Patients suffering from this disorder have a higher sensitivity to CO2/pH. It is known that the brain detects acid for several reasons besides ventilatory control, and the association between hypercapnia and panic disorders is quite strong. Thus, the present project intends to provide a detailed view of the neuronal and glial factors of the LC that determine the chemosensitive gain to CO2/pH and to identify targets for possible clinical treatments of disorders involving abnormal central detection of CO2. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BIANCARDI, VIVIAN; PATRONE, LUIS GUSTAVO A.; VICENTE, MARIANE C.; MARQUES, DANUZIA A.; BICEGO, KENIA C.; FUNK, GREGORY D.; GARGAGLIONI, LUCIANE H.. Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats. Journal of Applied Physiology, v. 133, n. 2, p. 19-pg., . (12/19966-0, 20/01702-2, 12/15298-2)
BERNARDES-RIBEIRO, MARIANA H.; PATRONE, LUIS GUSTAVO A.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Role of central irisin in the cardiorespiratory and metabolic control of adult rats. FASEB JOURNAL, v. 36, p. 1-pg., . (20/01702-2)
DA SILVA JUNIOR, CARLOS APARECIDO; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; VILELA-COSTA, HELOISA H.; MARQUES, DANUZIA A.; CRISTINA-SILVA, CAROLINE; DA COSTA SILVA, KAOMA STEPHANI; BICEGO, KENIA C.; SZAWKA, RAPHAEL E.; GARGAGLIONI, LUCIANE H.. Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 474, n. 11, p. 16-pg., . (17/05318-0, 16/17681-9, 20/01702-2, 17/26367-9)
PATRONE, LUIS GUSTAVO A.; ROCHA, ALINE C. G.; BERNARDES-RIBEIRO, MARIANA; LOPES-DA-COSTA, GLEYCE; MACARI, MARCOS; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Heat stress affects breathing and metabolism of chicks incubated at high temperature. Respiratory Physiology & Neurobiology, v. 314, p. 6-pg., . (20/01702-2, 21/13370-7, 19/14646-6)
RIPAMONTE, GABRIEL C.; FONSECA, ELISA M.; VILELLA-COSTA, HELOISA H.; ZANGROSSI, HELIO, JR.; BICEGO, KENIA C.; PLUMMER, NICHOLAS W.; JENSEN, PATRICIA; GARGAGLIONI, LUCIANE H.. Locus coeruleus noradrenergic neurons mediate panic-like escape response elicited by CO2. FASEB JOURNAL, v. 36, p. 1-pg., . (20/01702-2)
DA SILVA JUNIOR, CARLOS APARECIDO; MARQUES, DANUZIA A.; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience Letters, v. 795, p. 8-pg., . (20/01702-2, 16/17681-9, 17/26367-9, 17/05318-0)

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