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Autonomic (sympathetic and parasympathetic) modulation of cardiovascular and inflammatory responses under physiopathological clinical and experimental conditions

Grant number: 20/06043-7
Support Opportunities:Research Projects - Thematic Grants
Duration: May 01, 2021 - April 30, 2026
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Helio Cesar Salgado
Grantee:Helio Cesar Salgado
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Cláudia Helena Lovato da Silva ; Michel Reis Messora ; Rubens Fazan Junior
Associated researchers:Adriana Barbosa Ribeiro ; Adriana Campos Passanezi SantAna ; Alexandre Kanashiro ; Aline Barbosa Ribeiro ; Carlos Augusto Fernandes Molina ; Carlos Ferreira dos Santos ; Elen Rizzi Sanchez ; Fábio Nelson Gava ; Heloísa Della Coletta Francescato ; José Carlos Farias Alves Filho ; Juliana Pfrimer Falcão ; Marcus Vinicius Simões ; Marina de Toledo Durand ; Michel Reis Messora ; Minna Moreira Dias Romano ; Renata Maria Lataro ; Sandra Yasuyo Fukada Alves ; Silvia Carolina Guatimosim Fonseca ; Terezila Machado Coimbra
Associated scholarship(s):23/17746-7 - Relationship among Denture Stomatitis (DS), microbial load and expression of virulence genes with cardiovascular risk: observational cross-sectional study, BP.DR
24/01181-3 - Experimental Subproject 3: Investigation of the physiopathological cardiocirculatory and inflammatory mechanisms in rats with stomatitis., BP.PD
22/07579-3 - Experimental periodontitis in genetically modified mice (VAChT and Super VAChT): cardiovascular and inflammatory aspects, BP.PD
+ associated scholarships 22/11004-6 - INFLAMMATORY AND CARDIOCIRCULATORY RESPONSES IN EXPERIMENTAL STOMATITIS, BP.IC
22/05983-1 - Autonomic modulation - sympathy and parasympathic in: chronic Periodontitis investigated by variations in cardiac frequency, BP.DD
22/04995-6 - Relationship of prevalence, microbial load of Candida species and degree of denture-related stomatitis with heart risk, BP.IC
22/00203-8 - Effect of doxycycline on cardiocirculatory autonomic control in heart failure induced by myocardial infarction in rats, BP.IC
21/08622-7 - Inflammatory and cardiovascular responses in Experimental Periodontitis, using the bilateral ligation of the first mandibular molar, in Spontaneously Hypertensive Rats (SHR), BP.PD
21/06988-4 - Relation of the Denture Stomatits (DRS) with cardiovascular risk and the effect of denture disinfection compared to local treatment on DRS remission and cardiac risk: controlled, randomized, double-blind clinical trial, BP.PD - associated scholarships

Abstract

The Autonomic Nervous System (ANS) - Sympathetic and Parasympathetic - plays a role in the physiopathogenesis of cardiovascular diseases. Overall, there is a Sympathetic Overactivity contrasting with the Attenuation of Parasympathetic Function. It has also been demonstrated an interaction between the ANS and the Immune Systems (Innate and Adaptive), despite the mechanisms involved require more conspicuous examination. Besides, the interaction between the ANS and the Immune Systems (Innate and Adaptive) in the physiopathogenesis of Stomatitis and Periodontitis remains uncertain. To develop Experimental (Myocardial Infarction, Arterial Hypertension, Heart Failure, Periodontitis, and Stomatitis) and Clinical (Periodontitis and Stomatitis) protocols, with the purpose to better characterize the interaction of the ANS and the Immune Systems (Innate and Adaptive), and their causal relationship. Experimentally, it will be used rats (Wistar, Sprague-Dawley and Spontaneously Hypertensive Rats (SHR) and mice with attenuation (VAChT KD) or overexpression (Super VAChT) of the vesicular acetylcholine transporter. Clinically, it will be studied Patients with Periodontitis or Stomatitis. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BROGNARA, FERNANDA; CASTANIA, JACI AIRTON; RIBEIRO, ALINE BARBOSA; SANTOS-JUNIOR, NILTON NASCIMENTO; SALGADO, HELIO CESAR. The Bezold-Jarisch Reflex and The Inflammatory Response Modulation in Unanesthetized Endotoxemic Rats. FRONTIERS IN PHYSIOLOGY, v. 12, . (13/20549-7, 20/06043-7, 18/10455-9, 18/20939-3, 17/05163-6)
GUIMARAES, DIOGO A.; AQUINO, NAYARA S. S.; ROCHA-RESENDE, CIBELE; JESUS, ITAMAR C. G.; SILVA, MARIO MORAIS; SCALZO, SERGIO A.; FONSECA, ROBERTA CRISTELLI; DURAND, MARINA T.; PEREIRA, VANESSA; TEZINI, GEISA C. S., V; et al. Neuronal cholinergic signaling constrains norepinephrine activity in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 322, n. 4, p. 8-pg., . (20/06043-7)
BUZINARI, TEREZA; CASTANIA, JACI; SALVADOR, SERGIO; SALGADO, HELIO. Periodontitis accelerates the development of arterial hypertension in spontaneously hypertensive rats (SHR). PHYSIOLOGY, v. 38, p. 2-pg., . (21/08622-7, 20/06043-7)
DURAND, MARINA; SANCHES, ELEN; COSTA, LUCAS; SILVA, CARLOS; BUZINARI, TEREZA; SALGADO, HELIO; FAZAN, RUBENS, JR.. Effect of doxycycline in autonomic modulation of the heart, assessed by heart rate variability, in rats with myocardial infarction. PHYSIOLOGY, v. 38, p. 2-pg., . (20/06043-7)
CESARINO, LUIZ G.; BROGNARA, FERNANDA; CASTANIA, JACI A.; SALGADO, HELIO C.. Baroreflex Activation Contributes to the Progression of the Systemic Inflammatory Response in Unanesthetized Rats. FASEB JOURNAL, v. 36, p. 1-pg., . (20/06043-7, 20/08312-5, 21/03764-8)
RIBEIRO, ALINE BARBOSA; DA SILVA, THAIS MARQUES; SANTOS-JUNIOR, NILTON NASCIMENTO; CASTANIA, JACI AIRTON; FAZAN, JR., RUBENS; SALGADO, HELIO CESAR. Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats. BMC ORAL HEALTH, v. 21, n. 1, . (18/20939-3, 18/10455-9, 20/06043-7)
RIBEIRO, ADRIANA BARBOSA; RIBEIRO, ALINE BARBOSA; DE ARAUJO, CAMILA BORBA; FORTES, CAROLINE VIEIRA; CLEMENTE, LORENA MOSCONI; OLIVEIRA PARANHOS, HELENA DE FREITAS; WATANABE, EVANDRO; SALGADO, HELIO CESAR; SILVA-LOVATO, CLAUDIA HELENA. Effect of a Hygiene Protocol on Denture-Related Stomatitis Remission, Local Inflammatory Factors, and Hemodynamic Responses by Arterial Pressure. ANTIBIOTICS-BASEL, v. 11, n. 10, p. 13-pg., . (20/06043-7, 21/06988-4)
ELEONORA NARDI CAMPOS; LORENA MOSCONI CLEMENTE; PILLAR GONÇALVES PIZZIOLO; VIVIANE DE CÁSSIA OLIVEIRA; ANA PAULA MACEDO; EVANDRO WATANABE; CLÁUDIA HELENA SILVA-LOVATO; ADRIANA BARBOSA RIBEIRO. Relation between the risk factors for the severity of denture stomatitis and quality of life of complete edentulous individuals: a cross-sectional study. Journal of Applied Oral Science, v. 31, . (21/06988-4, 20/06043-7)

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