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Analysis of different desensitizing treatments on dentin hypersensitivity: in vitro and in vivo studies

Grant number: 20/07625-0
Support Opportunities:Regular Research Grants
Duration: April 01, 2021 - March 31, 2023
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Ticiane Cestari Fagundes
Grantee:Ticiane Cestari Fagundes
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Associated researchers:Alberto Carlos Botazzo Delbem ; Juliano Pelim Pessan


Dentin hypersensitivity is frequently observed in dental practice, but no ideal treatment protocol for these cases is available in the literature. The aim of this study will be to investigate the effects of different categories of treatments for dentin hypersensitivity using the following protocols: placebo varnish (negative control - PV), fluoride varnishes (Duraphat, positive control - FV); experimental varnish (NaF 5% + 5% TMP - TV); bioactive ceramic crystalline solution (Biosilicato® - SS); amelotin solution (AS); dental adhesive system (Single Bond Universal - SB); light-cured fluoride varnish (PRG - LV). In the in vitro study (Subproject I), 140 blocks of bovine root dentin will be treated to different desensitizing treatments, and submitted to erosive-abrasive challenges. Blocks will be analyzed by dentin permeability, wear, infiltration into dentin, and dentin tubule obliteration. Cytotoxicity analysis will also be performed using protein quantification (Subproject II). Of the six treatments proposed in vitro, the three that obtain the best results will be tested in vivo, in addition to the FV group One hundred and ninety-two teeth (48 for each treatment) with exposed root with dentin hypersensitivity (without cavity) will be treated in a randomized and parallel study (Subproject III). Each patient will be treated with the same desensitizing protocol. The degree of dentin sensitivity will be analyzed using the visual analogue scale (VAS), and computerized visual scale (CoVAS), at baseline (prior to treatment), and at 7, 15, 30 days, 6 and 12 months after treatment. The results will be subjected to specific statistical tests. It is expected that the present study will contribute to the knowledge about the mechanism involved in new desensitizing treatment, as well as to obtain an innovative and effective clinical protocol for dentin hypersensitivity. (AU)

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