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Cannabidiol (CBD) in patients with mild to moderate symptoms of coronavirus 2019: a randomized, double-blind, placebo-controlled clinical trial


The aim of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabidiol (CBD - 300 mg a day) in patients infected with SARS-CoV-2. The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: I) decrease viral load; II) modify inflammatory parameters, such as cytokines, measured from serum; II) reduceclinical and emotional symptoms through daily clinical evaluation; IV) improve the quality of life and sleep; V) reduce hospitalization and worsen the severity of the disease; v) Monitor the possible adverse effects of CBD use in these patients VI) Evaluate whether CBD 300 mg can prevent depression, burnout, PTSD and other neuropsychiatric disorders in SARS-CoV-2 patients; VII) Evaluate if CBD can prevent central structural and functional abnormalities in SARS-CoV-2 patients as assessed by DTI diffusion tensor imaging and rsfMRI - resting-state functional magnetic resonance imaging. (AU)

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