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Characterization molecular and phenotypic of opportunistic bacteria: development of vaccines and drugs using subtractive proteomics

Abstract

The evolution, the increased prevalence and the spread of bacteria resistant to multiple antibiotics, aggravated by the lack of new drugs, produces a serious global problem for the control and management of infections. Molecular techniques have been used to mitigate some of these problems. Most of these techniques can be used to identify genes and genetic elements responsible for the dissemination of antibiotic resistance determinants and virulence factors, and also allow the identification of potential therapeutic candidates that can be used in the clinical management of infected patients. Therefore, we are proposing molecular studies on the antimicrobial resistance profile; virulence; phylogenetic analyzes; sequencing, and genome analysis of opportunistic bacteria such as Serratia marcescens, Klebsiella pneumoniae and Staphylococci strains. We also intend, through subtractive proteomics and reverse vaccinology techniques, to find potential drug targets and vaccine candidates that can be used against S. marcescens, an opportunistic pathogen, that have become multidrug resistant (MDR) and have been associated with serious infections and high mortality rate. The data obtained will provide important information about the reservoirs of resistance and virulence genes, the genetic relationships, and will be useful for identification of new therapeutic compounds against MDR bacteria. (AU)

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