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Melatonin physiology and pathophysiology, basic and clinical studies: characterization of the primary and secundary Hypomelatoninemia Syndromes

Grant number: 19/24327-5
Support type:Research Projects - Thematic Grants
Duration: February 01, 2021 - January 31, 2026
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:José Cipolla Neto
Grantee:José Cipolla Neto
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Adriana Aparecida Siviero Miachon ; Andrea Maria Cappellano ; Angela Maria Spinola Castro ; Angelo Rafael Carpinelli ; Ariane Ferreira Machado Avelar ; Bruno Halpern ; Carolina Beltrame Del Debbio ; Clarissa Bueno ; Claudia Roberta de Castro Moreno ; Cristoforo Scavone ; DIEGO DE CASTRO DOS SANTOS ; Elaine Cristina Marqueze ; Elisa Mitiko Kawamoto Iwashe ; Fernanda Gaspar Do Amaral ; Fernanda Marques da Cunha ; Fernando Maurício Francis Abdalla ; Gisele Giannocco ; Jackson Cioni Bittencourt ; Kátia de Angelis Lobo D Avila ; Leandro Campos de Brito ; Leticia Maria Santoro Franco Azevedo Soster ; Luciana Aparecida Campos Baltatu ; Maria Lucia Cardillo Corrêa Giannella ; Maria Paz Loayza Hidalgo ; Maria Regina Lopes Sandoval ; Maria Tereza Nunes ; Maristela de Oliveira Poletini ; Nasjla Saba da Silva ; Ovidiu Constantin Baltatu ; Raphael Escorsim Szawka ; Raquel Chacon Ruiz Martinez ; Rubens Gisbert Cury ; Solange Castro Afeche ; Taiza Stumpp Teixeira
Associated scholarship(s):21/09923-0 - The role of melatonin on the heritable variation in the endocrine pancreas of the offspring of rats in hypomelatoninemia during pregnancy: From B cell transdifferentiation to epigenetics., BP.PD


Using a new conceptual framework of analysis of melatonin physiology and pathophysiology, the aim of this project is to study the Hypomelatoninemia Syndrome, either primary or secondary. The project is divided in three groups of research. The first group aims to study the consequences of the absence and therapeutic replacement of melatonin onseveral aspects of pregnancy physiology and fetal development and programming. In addition of studying maternal pancreatic remodelling, melatonin synthesis and maternal neurogenesis, the offspring (male and female) will be studied just after weaning, as young and during the aging process. The physiological and pathophysiological areas included in this experimental study are glucose metabolism, lipid metabolism, energy metabolism, male and female reproduction, thyroid endocrinology, cardiovascular system and blood pressure regulation, circadian rhythmicity, learning ability, neural plasticity and neural susceptibility to drug action. The second group of research aims to characterize the human Hypomelatoninemic Syndrome, either primary or secondary, in several clinical conditions. The patients (pinealectomized, Diabetes type 1, Parkinson Disease, Autism and Bipolar Disorders) will be studied on glucose, lipid and energy metabolism, cardiovascular system, blood pressure regulation and heart rate variability, in addition to sleep and circadian rhythmicity. Moreover, the correlation between environmental illumination, melatonin synthesis and individual and transgenerational health will be considered in three situations: ICU patients, physiological adaptation to acute aerobic exercise and metabolic health and neural development of children born to mothers that worked during the night when pregnant. Finaly, in a third group of research the aim is to study the balance between pineal melatonin and local produced melatonin on retinal and cerebral coroid plexus functions. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, R. P. O.; NEHME, P. X. S. A.; MARQUEZE, E. C.; AMARAL, F. G.; CIPOLLA-NETO, J.; MORENO, C. R. C.. High social jetlag is correlated with nocturnal inhibition of melatonin production among night workers. CHRONOBIOLOGY INTERNATIONAL, v. 38, n. 8, p. 1170-1176, . (14/50457-0, 19/24327-5, 16/11155-3)

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