Advanced search
Start date
Betweenand

Super resoulution microscopies applied to the study of tirosin kinase 2 (PTK2) and miosin V family roles in the DNA damage response in cardiomiocites under genotoxic stress

Grant number: 20/11824-8
Support Opportunities:Regular Research Grants
Duration: March 01, 2021 - February 29, 2024
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Andre Alexandre de Thomaz
Grantee:Andre Alexandre de Thomaz
Host Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Aline Mara dos Santos

Abstract

Cardiovascular complications of anticancer therapies have emerged as a critical problem in public health, especially if we consider that cancer survival rate is increasing in the last years. Cardiotoxicity due to chemotherapy, like treatment with doxorubicin (doxo), is a serious condition, which can evolve to chronic cardiopathy leading to death. Studies focused on signaling activated by anticancer therapies have been showing an important role of the protein tyrosine kinase 2 (PTK2) in the cellular survival and resistance, however, this signaling is not well understood. This research proposal aims to investigate the molecular basis of this cellular resistance and survival, by verifying the interaction between PTK2 with proteins associated with DNA damage response, such as PARP1 and MRE11. It is also our objective to elucidate the transport mechanism of PTK2 in the cytoplasm and nucleus and to verify the role of the molecular motor family of myosins V in the DNA damage response. Our results could contribute to the understanding of the mechanisms in which PTK2 promotes cellular survival after doxo treatment and to the establishment of new treatments to cancer with decreasing deleterious effects to the cardiac function. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, MARIANA CONCEICAO; FABIANO, LILIAN CATARIM; DA COSTA SALOMAO, KARILE CRISTINA; DE FREITAS, PEDRO LUIZ ZONTA; NEVES, CAMILA QUAGLIO; BORGES, STEPHANIE CARVALHO; CARVALHO, MARIA DAS GRACAS DE SOUZA; BREITHAUPT-FALOPPA, ANA CRISTINA; DE THOMAZ, ANDRE ALEXANDRE; DOS SANTOS, ALINE MARA; et al. A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs. ANTIOXIDANTS, v. 12, n. 5, p. 21-pg., . (18/07383-6, 20/11824-8)

Please report errors in scientific publications list using this form.
X

Report errors in this page


Error details: