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Mitochondrial ion transporters as sensors and regulators in energy metabolism

Abstract

Mitochondria are the hub of energy metabolism, organelles in which carbohydrate, amino acid and lipid metabolism are completed, and most cellular ATP is produced through oxidative phosphorylation. Because of the dependence on high inner mitochondrial membrane potentials in order to sustain oxidative phosphorylation, ion transport through the inner mitochondrial membrane must be carefully regulated, and has a strong impact on metabolic processes. This project aims to understand how Ca2+ and K+ transport across the inner mitochondrial membrane regulate energy metabolism in mitochondria and the cell. Additionally, we will explore how Ca2+ and K+ transport in mitochondria are affected by nutritional and energetic status. We hope to uncover new mechanisms that regulate energy metabolism and responses to dietary nutritional states. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERNA, JULIAN D. C.; AMARAL, ANDRESSA G.; CALDEIRA DA SILVA, CAMILLE C.; MUNHOZ, ANA C.; VILAS-BOAS, ELOISA A.; MENEZES-FILHO, SERGIO L.; KOWALTOWSKI, ALICIA J.. Regulation of kidney mitochondrial function by caloric restriction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 323, n. 1, p. 15-pg., . (19/05226-3, 19/04233-6, 13/07937-8, 20/06970-5)
BARBOSA DAVID, CICERA EDNA; BRITO LUCAS, ALINE MARIA; OLIVEIRA CUNHA, PEDRO LOURENZO; PONTE VIANA, YUANA IVIA; YOSHINAGA, MARCOS YUKIO; MIYAMOTO, SAYURI; CHAVES FILHO, ADRIANO BRITO; NUNES VARELA, ANNA LIDIA; KOWALTOWSKI, ALICIA JULIANA; FACUNDO, HEBERTY TARSO. alorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertroph. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, v. 78, n. 1, p. 283-294, . (20/06970-5, 13/07937-8)
GHIROTTO, BRUNO; OLIVEIRA, DANYLLO F.; CIPELLI, MARCELLA; BASSO, PAULO J.; LIMA, JEAN; BREDA, CRISTIANE N. S.; RIBEIRO, HENRIQUE C.; SILVA, CAMILLE C. C.; SERTIE, ANDREA L.; OLIVEIRA, ANTONIO EDSON R.; et al. MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes. ANNALS OF NEUROLOGY, v. 91, n. 5, p. 18-pg., . (17/05264-7, 18/23460-0, 13/08028-1, 20/06970-5, 13/07937-8)
RAMOS, VITOR DE MIRANDA; KOWALTOWSKI, ALICIA J.; KAKIMOTO, PAMELA A.. Autophagy in Hepatic Steatosis: A Structured Review. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, . (20/06970-5, 13/07937-8, 19/18402-4, 15/25862-0)
KOWALTOWSKI, ALICIA J.. Cold Exposure and the Metabolism of Mice, Men, and Other Wonderful Creatures. PHYSIOLOGY, v. 37, n. 5, p. 7-pg., . (20/06970-5, 13/07937-8)
CABRAL-COSTA, JOAO VICTOR; KOWALTOWSKI, ALICIA J.. Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function. ESSAYS IN BIOCHEMISTRY, v. 67, n. 1, p. 13-pg., . (13/07937-8, 20/06970-5, 17/14713-0, 19/22178-2)
PEREIRA, OSVALDO; KOWALTOWSKI, ALICIA J.. Mitochondrial K+ Transport: Modulation and Functional Consequences. Molecules, v. 26, n. 10, . (20/06970-5, 13/07937-8)
PEREIRA JR, O. R.; RAMOS, V. M.; CABRAL-COSTA, J. V.; KOWALTOWSKI, A. J.. Changes in mitochondrial morphology modulate LPS-induced loss of calcium homeostasis in BV-2 microglial cells. Journal of Bioenergetics and Biomembranes, v. 53, n. 2, p. 109-118, . (19/18402-4, 19/22178-2, 20/06970-5, 17/14713-0, 18/21487-9, 13/07937-8)
CABRAL-COSTA, JOAO VICTOR; VICENTE-GUTIERREZ, CARLOS; AGULLA, JESUS; LAPRESA, REBECA; ELROD, JOHN W.; ALMEIDA, ANGELES; BOLANOS, JUAN P.; KOWALTOWSKI, ALICIA J.. Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance. Journal of Neurochemistry, v. N/A, p. 15-pg., . (13/07937-8, 17/14713-0, 20/06970-5, 19/22178-2)

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