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Pathophysiology and diagnosis of arthritogenic alphavirus infections

Grant number: 19/27333-6
Support type:Regular Research Grants
Duration: November 01, 2020 - October 31, 2022
Field of knowledge:Biological Sciences - Microbiology
Principal researcher:Luiz Tadeu Moraes Figueiredo
Grantee:Luiz Tadeu Moraes Figueiredo
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers: Nuno Miguel Rodrigues Pascoal Faria ; William Marciel de Souza


Chikungunya (CHIKV) and Mayaro (MAYV) viruses are arboviruses that cause acute and often symptomatic infections, which are associated with fever and debilitating polyarthralgia/polyarthritis. Recently, CHIKV infections have been associated with deaths in the Americas, which about 25% of these have been reported in Fortaleza, Ceará State, Brazil. On the other hand, MAYV is another endemic arthritogenic alphavirus present in the northern and central-west regions of Brazil, which are also endemic to CHIKV. Therefore, it is important to understand the immunological mechanisms of pre-existent immunity among arthritogenic alphaviruses, as well as to understand the real impact of MAYV to Brazilian's public health. Thus, we propose; (i) conduct a study of genomic epidemiology and pathophysiology in fatal CHIKV cases, (ii) elucidate the immunological mechanisms of cross-protection among circulating arthritogenic alphaviruses, and (iii) develop an accurate, sensitive and inexpensive diagnostic method for MAYV. To achieve this, we will perform a multi-platform omics analysis of fatal and non-fatal CHIKV patients to identify key virus-host interactions related to disease severity. In addition, we will evaluated the immunological mechanisms of cross-protection between arthritogenic alphaviruses using in vitro and in vivo approaches, and we will develop a low cost molecular diagnostic method of easy visualization for MAYV. Therefore, this study will shed light in the evolution, epidemiology, pathogenesis, and diagnostic development of arboviruses that cause human diseases. (AU)

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