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Investigating the evolution of satellite DNAs in holocentric chromosomes of pest species


The satellite DNAs (satDNA) are repetitive sequences organized in tandem, forming in general large arrays and comprising large portion of eukaryote genomes. They are peculiarly enriched in heterochromatic regions, mainly in centromeres. These sequences play role in chromosomal structure and recently functionality for them has been described. The genomic and chromosomal organization and the evolutionary patterns for this DNA class are well known in species with monocentric chromosomes (located centromeres). The theories about satDNA evolution, like the library hypothesis and concerted evolution were postulated in monocentric chromosomes. On the other hand, among species with holocentric chromosomes (diffuse centromere) almost no knowledge about molecular evolution of this DNA class was obtained. This group is interesting for analysis due to the disperse organization for heterochromatin that could influence the evolution of satDNAs. The study of satDNA in species with holocentric chromosomes will allow the test of hypothesis about satDNA evolution and their impact in the karyotypic organization and variability. Moreover, it will be possible the generation of broader theories about satDNA biology. In this way, in this proposal we intend to advance in the knowledge about structure and evolution of satDNAs, using as experimental models pest insects (Hemiptera and Lepidoptera) with holocentric chromosomes. Finally, we will contribute with the genome assembling of pest species that could have applicability in the future. For this aim we will use an integrative analysis combining cytogenetics, genomics (next generation sequencing) and bioinformatics. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, JAQUELINE A.; MILANI, DIOGO; FERRETTI, ANA BEATRIZ S. M.; BARDELLA, VANESSA B.; CABRAL-DE-MELLO, DIOGO C.; LOPES, DENILCE M.. The extensive amplification of heterochromatin in Melipona bees revealed by high throughput genomic and chromosomal analysis. CHROMOSOMA, v. 130, n. 4, . (20/06188-5, 19/19069-7, 18/21772-5)
CABRAL-DE-MELLO, DIOGO C.; ZRZAVA, MAGDA; KUBICKOVA, SVATAVA; RENDON, PEDRO; MAREC, FRANTISEK. The Role of Satellite DNAs in Genome Architecture and Sex Chromosome Evolution in Crambidae Moths. FRONTIERS IN GENETICS, v. 12, . (19/19069-7)
BARDELLA, VANESSA BELLINI; MILANI, DIOGO; CABRAL-DE-MELLO, DIOGO CAVALCANTI. Analysis ofHolhymenia histriogenome provides insight into the satDNA evolution in an insect with holocentric chromosomes. Chromosome Research, v. 28, n. 3-4, p. 369-380, . (19/19069-7, 18/21772-5)
MARTI, EMILIANO; MILANI, DIOGO; BARDELLA, VANESSA B.; ALBUQUERQUE, LUCAS; SONG, HOJUN; PALACIOS-GIMENEZ, OCTAVIO M.; CABRAL-DE-MELLO, DIOGO C.. Cytogenomic analysis unveils mixed molecular evolution and recurrent chromosomal rearrangements shaping the multigene families on Schistocerca grasshopper genomes. Evolution, v. 75, n. 8, p. 2027-2041, . (14/11763-8, 19/19069-7)
MENEZES, RODOLPHO S. T.; CABRAL-DE-MELLO, DIOGO C.; MILANI, DIOGO; BARDELLA, VANESSA B.; ALMEIDA, EDUARDO A. B.. The relevance of chromosome fissions for major ribosomal DNA dispersion in hymenopteran insects. JOURNAL OF EVOLUTIONARY BIOLOGY, v. 34, n. 9, . (15/02432-0, 14/11763-8, 19/19069-7, 18/09666-5, 16/21098-7)
CABRAL-DE-MELLO, DIOGO CAVALCANTI; MAREC, FRANTISEK. Universal fluorescence in situ hybridization (FISH) protocol for mapping repetitive DNAs in insects and other arthropods. Molecular Genetics and Genomics, v. 296, n. 3, . (19/19069-7)

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