Advanced search
Start date
Betweenand

Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics

Grant number: 19/05856-7
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2020 - January 31, 2025
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Cristiane Yumi Koga Ito
Grantee:Cristiane Yumi Koga Ito
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
Pesquisadores principais:
Konstantin Georgiev Kostov ; Rodrigo Savio Pessoa
Associated researchers:Gabriela de Morais Gouvêa Lima ; Helena Maria Marcolla Araujo ; Marcelo Vidigal Caliari ; Marcia Hiromi Tanaka ; Marcia Pinto Alves Mayer ; Paulo Francisco Guerreiro Cardoso ; Simone Duarte ; Thalita Mayumi Castaldelli Nishime ; William Chiappim Junior
Associated grant(s):23/02410-3 - Emerging applications of atmospheric cold plasmas in medical and dentistry fields, AV.BR
Associated scholarship(s):23/12059-1 - Effectiveness of water activated by dielectric barrier discharge (DBD) plasma as an irrigating agent in endodontics, BP.MS
22/00266-0 - EVALUATION OF ANTIMICROBIAL ACTIVITY OF POLYMETHYLMACRYLATE (PMMA) COATED WITH THIN FILMS OF Al2O3 GROWN BY PLASMA-ACTIVATED WATER-ENHANCED ATOMIC LAYER DEPOSITION FOR DENTAL APPLICATION, BP.DR
23/10438-5 - Application of nebulized plasma activated water as an effective antimicrobial agent in the inactivation of biofilms of clinically relevant microbial species, BP.IC
+ associated scholarships 23/02268-2 - Generation and characterization of different liquids activated with plasma for use in endodontic treatment, BP.PD
22/13141-0 - Activation of deionized water and saline solution by jet of plasma generated in surfatron reactor, BP.IC
21/09335-1 - Polycaprolactone-based electrotrophied nanofibers, cellulose nanocrystals and Melaleuca alternifolia essential oil for tissue regeneration, BP.DR
21/14181-3 - Development and study of a plasma system generated by dielectric barrier discharge (DBD) for continuous activation of liquids applied in dental treatments, BP.PD
21/05351-2 - Study of properties of cold atmospheric plasma jet designed for inactivation of different microorganisms and healing of living tissues, BP.TT
21/03620-6 - Application and characterization of a gliding arc plasma jet in the activation of liquids for applications related to Dentistry, BP.IC
21/02680-5 - Study of cold plasma jet operating in atmospheric pressure for biomedical applications, BP.DD
21/00046-7 - Association of L-ascorbic acid and cold atmospheric pressure plasma in the treatment of oral candidiasis: in vitro and in vivo evaluation, BP.PD
19/25652-7 - Low-temperature plasma under atmospheric pressure as an adjuvant for the treatment of Oral Mucositis, BP.DR
20/10450-7 - Exploring the potential of plasma activated liquid (PAL): characterization of plasma and application of PAL in endodontic treatment, BP.PD
20/09481-5 - Applications of non-thermal atmospheric plasmas in Dentistry: from the bench to the clinic, BP.PD - associated scholarships

Abstract

This proposal aims to investigate the use of low temperature atmospheric pressure plasma (LTAPP) in Dentistry. The general aim is to develop protocols for the application of plasma and plasma activated liquid in vivo and ex vivo for diseases of dental interest and a portable equipment for clinical use. The specific aims are to develop effective protocols to the following relevant pathological conditions in Dentistry: oral candidosis, periodontitis, dental caries, endodontic infection and oral mucositis. Protocols of direct plasma application or plasma treated liquid (PTL, indirect application) will be tested. In case of infectious diseases, the effective parameters of LTAPP against each specific pathogenic biofilm will be standardized in vitro. After, these parameters will be evaluated for cyto and genotoxicity, using the most suitable cell line for each case. The effective (maximum antimicrobial effect) and safe (lowest toxicity) will be applied in vivo or ex vivo for validation. In relation to mucositis, the protocols of direct or indirect application will be evaluated in rats treated with 5-fluorouracyl, followed by histologic and immunohistochemical analyses. Systemic toxicity of PTL will be evaluated using Drosophila melanogaster model. The plasma device to be used in this study was developed and validated by the team of this project, with the support of several publications. For this reason, it is also aim of this project to transpose the current equipment to a small and portable prototype, maintaining its potentialities. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE; MIRANDA, FELIPE; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; CARDOSO, PAULO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. Nebulized plasma-activated water has an effective antimicrobial effect on medically relevant microbial species and maintains its physicochemical properties in tube lengths from 0.1 up to 1.0 m. Plasma Processes and Polymers, v. 18, n. 11, . (19/25652-7, 19/05856-7, 20/10450-7)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; MIRANDA, FELIPE; FRAGA, MARIANA; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. ntimicrobial Effect of Plasma-Activated Tap Water on Staphylococcus aureus, Escherichia coli, and Candida albican. WATER, v. 13, n. 11, . (19/25652-7, 19/05856-7, 18/01265-1, 20/10450-7)
FIGUEIRA, LEANDRO W.; PANARIELLO, BEATRIZ H. D.; KOGA-ITO, CRISTIANE Y.; DUARTE, SIMONE. Low-Temperature Plasma as an Approach for Inhibiting a Multi-Species Cariogenic Biofilm. APPLIED SCIENCES-BASEL, v. 11, n. 2, . (19/01676-4, 19/05856-7)
DO NASCIMENTO, FELLYPE; QUADE, ANTJE; CANESQUI, MARA ADRIANA; KOSTOV, KONSTANTIN GEORGIEV. Different configurations of transferred atmospheric pressure plasma jet and their application to polymer treatment. CONTRIBUTIONS TO PLASMA PHYSICS, v. 63, n. 1, p. 14-pg., . (20/09481-5, 19/05856-7)
MUNIZ, ANA BESSA; VEGIAN, MARIANA RAQUEL DA CRUZ; LEITE, LADY DAIANE PEREIRA; DA SILVA, DIEGO MORAIS; MILHAN, NOALA VICENSOTO MOREIRA; KOSTOV, KONSTANTIN GEORGIEV; KOGA-ITO, CRISTIANE YUMI. Non-Thermal Atmospheric Pressure Plasma Application in Endodontics. BIOMEDICINES, v. 11, n. 5, p. 13-pg., . (19/05856-7)
KODAIRA, FELIPE VICENTE DE PAULA; LEAL, BRUNO HENRIQUE SILVA; TAVARES, THAYNA FERNANDES; QUADE, ANTJE; HEIN, LUIS ROGERIO DE OLIVEIRA; CHIAPPIM, WILLIAM; KOSTOV, KONSTANTIN GEORGIEV. Simultaneous Treatment of Both Sides of the Polymer with a Conical-Shaped Atmospheric Pressure Plasma Jet. POLYMERS, v. 15, n. 2, p. 14-pg., . (19/05856-7, 20/10450-7)
DO NASCIMENTO, FELLYPE; GERLING, TORSTEN; KOSTOV, KONSTANTIN GEORGIEV. On the gas heating effect of helium atmospheric pressure plasma jet. PHYSICA SCRIPTA, v. 98, n. 5, p. 15-pg., . (19/05856-7, 21/14391-8)
KODAIRA, FELIPE VICENTE DE PAULA; ALMEIDA, ANA CARLA DE PAULA LEITE; TAVARES, THAYNA FERNANDES; QUADE, ANTJE; HEIN, LUIS ROGERIO DE OLIVEIRA; KOSTOV, KONSTANTIN GEORGIEV. Study of a Conical Plasma Jet with a Cloth-Covered Nozzle for Polymer Treatment. POLYMERS, v. 15, n. 16, p. 14-pg., . (19/05856-7)
MILHAN, NOALA VICENSOTO MOREIRA; CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; VEGIAN, MARIANA RAQUEL DA CRUZ; PESSOA, RODRIGO SAVIO; KOGA-ITO, CRISTIANE YUMI. Applications of Plasma-Activated Water in Dentistry: A Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 8, p. 26-pg., . (20/10450-7, 19/25652-7, 21/00046-7, 19/05856-7)
NASCIMENTO, FELLYPE; PETROSKI, KLEBER; KOSTOV, KONSTANTIN. Effects of O-2 Addition on the Discharge Parameters and Production of Reactive Species of a Transferred Atmospheric Pressure Plasma Jet. APPLIED SCIENCES-BASEL, v. 11, n. 14, . (20/09481-5, 19/05856-7)
KOGA-ITO, CRISTIANE YUMI; KOSTOV, K. G.; MIRANDA, F. S.; MILHAN, N. V. M.; NETO, N. F. AZEVEDO; NASCIMENTO, F.; PESSOA, R. S.. Cold Atmospheric Plasma as a Therapeutic Tool in Medicine and Dentistry. PLASMA CHEMISTRY AND PLASMA PROCESSING, v. N/A, p. 37-pg., . (16/07196-6, 21/14181-3, 23/02268-2, 19/05856-7, 20/09481-5)
DO NASCIMENTO, FELLYPE; LEAL, BRUNO SILVA; QUADE, ANTJE; KOSTOV, KONSTANTIN GEORGIEV. Different Radial Modification Profiles Observed on APPJ-Treated Polypropylene Surfaces according to the Distance between Plasma Outlet and Target. POLYMERS, v. 14, n. 21, p. 17-pg., . (20/09481-5, 19/05856-7, 21/14391-8)
SAMPAIO, ALINE DA GRACA; CHIAPPIM, WILLIAM; MOREIRA MILHAN, NOALA VICENSOTO; NETO, BENEDITO BOTAN; PESSOA, RODRIGO; KOGA-ITO, CRISTIANE YUMI. Effect of the pH on the Antibacterial Potential and Cytotoxicity of Different Plasma-Activated Liquids. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 22, p. 21-pg., . (19/05856-7, 19/25652-7, 21/00046-7, 20/10450-7)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; MIRANDA, FELIPE; FRAGA, MARIANA; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. Antimicrobial Effect of Plasma-Activated Tap Water on Staphylococcus aureus, Escherichia coli, and Candida albicans. WATER, v. 13, n. 11, p. 16-pg., . (19/05856-7, 20/10450-7, 19/25652-7, 18/01265-1)
BORGES, ALINE C.; KOSTOV, KONSTANTIN G.; PESSOA, RODRIGO S.; DE ABREU, GERALDO M. A.; LIMA, GABRIELA DE M. G.; FIGUEIRA, LEANDRO W.; KOGA-ITO, CRISTIANE Y.. Applications of Cold Atmospheric Pressure Plasma in Dentistry. APPLIED SCIENCES-BASEL, v. 11, n. 5, . (19/05856-7, 18/17707-3)
PEREIRA LEITE, LADY DAIANE; CARVALHO DE OLIVEIRA, MARIA ALCIONEIA; DA CRUZ VEGIAN, MARIANA RAQUEL; SAMPAIO, ALINE DA GRACA; NISHIME, THALITA MAYUMI CASTALDELLI; KOSTOV, KONSTANTIN GEORGIEV; KOGA-ITO, CRISTIANE YUMI. Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms. Molecules, v. 26, n. 19, p. 12-pg., . (19/05856-7)

Please report errors in scientific publications list using this form.