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Advanced surface functionalizations aiming at corrosion and wear resistance and cell differentiation in Ti6Al4V ELI alloy customized mandibular prosthesis made by additive manufacturing

Grant number: 19/15441-9
Support Opportunities:Regular Research Grants
Duration: April 01, 2020 - November 30, 2022
Field of knowledge:Engineering - Mechanical Engineering - Manufacturing Processes
Convênio/Acordo: CONFAP - National Council of State Research Support Foundations
Principal Investigator:Cecilia Amelia de Carvalho Zavaglia
Grantee:Cecilia Amelia de Carvalho Zavaglia
Host Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:André Luiz Jardini Munhoz ; Anita Gaia Mazzocco ; Éder Sócrates Najar Lopes ; Guilherme Arthur Longhitano ; Luiz Henrique Martinez Antunes ; Miloslav Beres ; Rubens Maciel Filho


The temporomandibular joint (TMJ) is one of the most complex and solicited joints in human's body. It is involved in essential activities such as mastication, orality, breathing and facial expressions. When non-treatable by simple methods dysfunctions occur, the use of an implant is necessary. There are no TMJ prosthesis manufacturers in Brazil. Additive manufacturing is a technique capable of manufacturing complex geometries and patient-customized implants from medical images. In addition to geometry, an implant surface is responsible for the human's body interface. For achieving required surface properties and improve implants performance, surface finishes may be adopted. The implants surface finishes aim at improving biological response, accelerating osseointegration process, and, consequently, patient's recovery. This project will develop a jaw prosthesis with unprecedented properties in tissue regeneration area. A Ti6Al4V ELI alloy prosthesis developed by finite element analysis will be produced by additive manufacturing. Its surface will be functionalized through the processes of anodization, plasma assisted anodization and 3D bioprinting. In order to evaluate the prosthesis as an implant, microstructural, mechanical, physicochemical, morphological, electrochemical, tribological and biological (using mesenchymal stem cells) characterizations will be performed. Thus, a corrosion and wear-resistance customized prosthesis, with excellent biological properties, is intended. Furthermore, this research will feed cooperation between UFRGS and UNICAMP, developing Brazilian research. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LONGHITANO, GUILHERME ARTHUR; CONDE, ANA; ARENAS, MARIA ANGELES; JARDINI, ANDRE LUIZ; DE CARVALHO ZAVAGLIA, CECILIA AMELIA; MACIEL FILHO, RUBENS; JOSE DE DAMBORENEA, JUAN. Corrosion resistance improvement of additive manufactured scaffolds by anodizing. Electrochimica Acta, v. 366, . (19/15441-9, 20/05612-8)

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