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Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19

Abstract

The arrival of SARS-CoV-2 in Brazil in March 2020 negatively impacted the economy, generated panic in the population and disrupted our country's public and private health systems. It is evident that there is a need for rapid diagnostic / prognostic methods and therapeutic alternatives to deal with this pandemic in our country. Thus, this multidisciplinary project, which involves researchers from several units at Unicamp and other research institutions in Brazil and abroad, aims to use clinical specimens (nasopharyngeal swab, serum and frozen whole blood) already used in the diagnosis and other routine examinations and stored at the Clinical Pathology Laboratory of HC to: (1) Assess the circulation and genetic diversity of Covid-19 in Campinas; (2) Search for biomarkers that help us in the rapid diagnosis or in the prediction of fatal cases, using methodologies of proteomics, metabolomics and multiplex immunoassays; (3) Identify new antivirals through the repositioning of drugs already approved for use in humans, in addition to the discovery of new drug candidates, by computer screening tests and antiviral activity test in cell culture in a level 3 biological containment laboratory. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
El virus evoluciona 
The evolution of a virus 
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, LUCIANA C.; BENITES, BRUNO DELTREGGIA; ULAF, RAISA G.; NUNES, THYAGO A.; COSTA-LIMA, CAROLINA; ADDAS-CARVALHO, MARCELO; PROENCA-MODENA, JOSE LUIZ; GRANJA, FABIANA; DA COSTA, VITOR ANTONIO; SANTOS DUARTE, ADRIANA DA SILVA; et al. Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v. 17, n. 1, . (20/04558-0, 20/04522-5, 13/07607-8, 16/00194-8)
PASCOAL, LIVIA BITENCOURT; RODRIGUES, PATRICIA BRITO; GENARO, LIVIA MOREIRA; DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO; TOLEDO-TEIXEIRA, DANIEL AUGUSTO; PARISE, PIERINA LORENCINI; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA LOPES; GUIMARAES, PAULA VERI; BUSCARATTI, LUCAS ILDEFONSO; et al. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. GUT MICROBES, v. 13, n. 1, p. 1-9, . (20/04558-0, 20/04583-4, 20/02448-2, 20/02312-3, 19/14342-7, 20/04746-0, 17/26908-0, 20/04579-7, 20/04919-2, 19/06372-3, 13/07607-8, 20/02159-0)
BORIN, ALEXANDRE; COIMBRA, LAIS D.; BISPO-DOS-SANTOS, KARINA; NACIUK, FABRICIO F.; FONTOURA, MARINA; SIMEONI, CAMILA L.; GOMES, GIOVANNI, V; AMORIM, MARIENE R.; GRAVINA, HUMBERTO D.; SHIMIZU, JACQUELINE FARINHA; et al. Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds. VIRULENCE, v. 13, n. 1, p. 18-pg., . (20/04558-0, 16/00194-8, 19/06459-1)
CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, . (20/04558-0, 16/00194-8, 19/21301-5, 18/14389-0, 18/14933-2, 17/13981-0, 20/04836-0, 18/25468-9, 16/18445-7, 18/09383-3, 18/17176-8, 19/12000-1, 19/07544-2, 19/24251-9)
RIBEIRO, LUCIANA C.; BENITES, BRUNO DELTREGGIA; ULAF, RAISA G.; NUNES, THYAGO A.; COSTA-LIMA, CAROLINA; ADDAS-CARVALHO, MARCELO; PROENCA-MODENA, JOSE LUIZ; GRANJA, FABIANA; DA COSTA, VITOR ANTONIO; SANTOS DUARTE, ADRIANA DA SILVA; et al. Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v. 17, n. 1, p. 4-pg., . (13/07607-8, 16/00194-8, 20/04522-5, 20/04558-0)
SABINO, JANINE S.; AMORIM, MARIENE R.; DE SOUZA, WILLIAM M.; MAREGA, LIA F.; MOFATTO, LUCIANA S.; TOLEDO-TEIXEIRA, DANIEL A.; FORATO, JULIA; STABELI, RODRIGO G.; COSTA, MARIA LAURA; SPILKI, FERNANDO R.; et al. Clearance of Persistent SARS-CoV-2 RNA Detection in a NF kappa B-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report. Viruses-Basel, v. 14, n. 5, p. 10-pg., . (20/04558-0, 18/14389-0, 16/00194-8, 18/14372-0)
DE SOUZA, WILLIAM M.; MURARO, STEFANIE P.; SOUZA, GABRIELA F.; AMORIM, MARIENE R.; SESTI-COSTA, RENATA; MOFATTO, LUCIANA S.; FORATO, JULIA; BARBOSA, PRISCILLA P.; TOLEDO-TEIXEIRA, DANIEL A.; BISPO-DOS-SANTOS, KARINA; et al. lusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccine. Viruses-Basel, v. 13, n. 11, . (16/00194-8, 18/14389-0, 18/13645-3, 17/26908-0, 20/02159-0, 17/13981-0, 19/09704-7, 18/10224-7, 19/24251-9, 20/04558-0)
SALGADO, BARBARA BATISTA; MAUES, FABIO CARMONA DE JESUS; JORDAO, MAELE; PEREIRA, RENATO LEMOS; TOLEDO-TEIXEIRA, DANIEL A.; PARISE, PIERINA L.; GRANJA, FABIANA; SOUZA, HIGO FERNANDO SANTOS; YAMAMOTO, MARCIO MASSAO; CHIANG, JANNIFER OLIVEIRA; et al. Antibody cross-reactivity and evidence of susceptibility to emerging Flaviviruses in the dengue-endemic Brazilian Amazon. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v. 129, p. 10-pg., . (16/00194-8, 20/04558-0)
DE SOUZA, WILLIAM DANILO FERNANDES; ZORZELLA-PEZAVENTO, SOFIA FERNANDA GONCALVES; AYUPE, MARINA CACADOR; SALGADO, CAIO LOUREIRO; OLIVEIRA, BERNARDO DE CASTRO; MOREIRA, FRANCIELLY; DA SILVA, GUILHERME WILLIAM; MURARO, STEFANIE PRIMON; DE SOUZA, GABRIELA FABIANO; PROENCA-MODENA, JOSE LUIZ; et al. Lung Inflammation Induced by Inactivated SARS-CoV-2 in C57BL/6 Female Mice Is Controlled by Intranasal Instillation of Vitamin D. CELLS, v. 12, n. 7, p. 24-pg., . (19/13916-0, 20/04558-0, 19/07771-9, 21/12768-7, 19/12691-4, 21/06881-5)
BAGNO, FLAVIA F.; ANDRADE, LUIS A. F.; SERGIO, SARAH A. R.; PARISE, PIERINA L.; TOLEDO-TEIXEIRA, DANIEL A.; GAZZINELLI, RICARDO T.; FERNANDES, ANA P. S. M.; TEIXEIRA, SANTUZA M. R.; GRANJA, FABIANA; PROENCA-MODENA, JOSE L.; et al. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses-Basel, v. 14, n. 3, p. 9-pg., . (16/00194-8, 20/04558-0)
FARIA, NUNO R.; MELLAN, THOMAS A.; WHITTAKER, CHARLES; CLARO, INGRA M.; CANDIDO, DARLAN DA S.; MISHRA, SWAPNIL; CRISPIM, MYUKI A. E.; SALES, FLAVIA C.; HAWRYLUK, IWONA; MCCRONE, JOHN T.; et al. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science, v. 372, n. 6544, p. 815+, . (20/04558-0, 19/21568-1, 19/21301-5, 18/14389-0, 17/13981-0, 20/04272-9, 18/25468-9, 16/18445-7, 19/21858-0, 18/17176-8, 19/12000-1, 19/07544-2, 18/12579-7, 19/24251-9)
VEGA, MAITE DUHALDE; OLIVERA, DANIELA; DAVANZO, GUSTAVO GASTAO; BERTULLO, MAURICIO; NOYA, VERONICA; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; CASTRO, ICARO; AREVALO, ANA PAULA; CRISPO, MARTINA; et al. PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease. SCIENCE ADVANCES, v. 8, n. 38, p. 13-pg., . (20/04558-0, 20/04579-7)
ANDRADE, LUIS A. F.; BAGNO, FLAVIA F.; SERGIO, SARAH A. R.; PARISE, PIERINA L.; TOLEDO-TEIXEIRA, DANIEL A.; FERNANDES, ANA P. S. M.; TEIXEIRA, SANTUZA M. R.; GRANJA, FABIANA; PROENCA-MODENA, JOSE LUIZ; DA FONSECA, FLAVIO G.. Heterogeneity of humoral response patterns in mildly symptomatic, non-hospitalized COVID-19 patients: A one-year longitudinal study. Experimental Biology and Medicine, v. 248, n. 10, p. 9-pg., . (16/00194-8, 20/04558-0)
AMORIM, MARIENE R.; SOUZA, WILLIAM M.; BARROS, JR., ANTONIO C. G.; TOLEDO-TEIXEIRA, DANIEL A.; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA L.; PARISE, PIERINA L.; VIEIRA, ALINE; FORATO, JULIA; CLARO, INGRA M.; et al. Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020. Emerging Infectious Diseases, v. 27, n. 6, p. 1737-1740, . (20/04558-0, 16/00194-8, 20/02448-2, 18/14389-0, 17/13981-0, 17/26908-0, 19/24251-9, 20/02159-0)
BRUNETTI, NATALIA S.; DAVANZO, GUSTAVO G.; DE MORAES, DIOGO; FERRARI, ALLAN J. R.; SOUZA, GABRIELA F.; MURARO, STEFANIE PRIMON; KNITTEL, THIAGO L.; BOLDRINI, VINICIUS O.; MONTEIRO, LAUAR B.; VIRGILIO-DA-SILVA, JOO VICTOR; et al. SARS-CoV-2 uses CD4 to infect T helper lymphocytes. eLIFE, v. 12, p. 26-pg., . (20/04558-0, 15/15626-8, 19/06459-1, 19/04726-2, 19/16116-4, 19/05155-9, 19/13552-8, 16/18031-8, 19/00098-7, 20/04583-4, 16/00194-8, 21/08354-2, 19/17007-4, 19/22398-2, 17/01184-9, 19/14465-1, 20/04579-7, 13/08293-7, 18/14933-2, 17/23920-9, 19/06372-3, 16/24163-4, 16/23328-0, 20/04919-2, 20/04746-0)
RODRIGUES, PATRICIA BRITO; GOMES, GIOVANNI FREITAS; ANGELIM, MONARA K. S. C.; SOUZA, GABRIELA F.; MURARO, STEFANIE PRIMON; TOLEDO-TEIXEIRA, DANIEL A.; CRUZ RATTIS, BRUNA AMANDA; PASSOS, AMANDA STEPHANE; PRAL, LAIS PASSARIELO; RODOVALHO, VINICIUS DE REZENDE; et al. Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice. CELLS, v. 11, n. 16, p. 16-pg., . (20/10282-7, 20/04558-0, 20/05211-3, 19/06372-3, 20/04583-4, 20/04746-0)
BARRETO, ESTER A.; CRUZ, AMANDA S.; VERAS, FLAVIO P.; MARTINS, RONALDO; BERNARDELLI, RAFAELLA S.; PAIVA, ISADORA M.; LIMA, THAIS M.; SINGH, YOUVIKA; GUIMARAES, RAPHAEL C.; DAMASCENO, SAMARA; et al. COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 120, n. 21, p. 10-pg., . (16/00194-8, 20/05040-4, 17/08264-8, 20/04558-0)
CARMO, HELISON RAFAEL P.; YOSHINAGA, MARCOS Y.; CASTILLO, ALEJANDRO ROSELL; CHAVES-FILHO, ADRIANO BRITTO; BONILHA, ISABELLA; BARRETO, JOAQUIM; MURARO, STEFANIE PRIMON; DE SOUZA, GABRIELA FABIANO; DAVANZO, GUSTAVO GASTAO; PERROUD JR, MAURICIO W.; et al. Phenotypic changes in low-density lipoprotein particles as markers of adverse clinical outcomes in COVID-19. MOLECULAR GENETICS AND METABOLISM, v. 138, n. 4, p. 8-pg., . (20/04558-0, 20/12649-5, 16/00194-8, 13/07937-8, 18/17792-0)
CODO, ANA CAMPOS; DAVANZO, GUSTAVO GASTAO; MONTEIRO, LAUAR DE BRITO; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; VIRGILIO-DA-SILVA, JOAO VICTOR; PRODONOFF, JULIANA SILVEIRA; CARREGARI, VICTOR CORASOLLA; OLIVEIRA DE BIAGI JUNIOR, CARLOS ALBERTO; CRUNFLI, FERNANDA; et al. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1 alpha/Glycolysis-Dependent Axis. Cell Metabolism, v. 32, n. 3, p. 15-pg., . (19/00098-7, 20/04558-0, 20/04522-5, 19/06372-3, 16/18031-8, 15/15626-8, 16/23328-0, 17/01184-9, 20/04919-2, 20/04583-4, 20/04579-7, 18/22505-0, 20/04746-0)
SACCON, TATIANA DANDOLINI; MOUSOVICH-NETO, FELIPPE; LUDWIG, RAISSA GUIMARAES; CARREGARI, VICTOR CORASOLLA; DOS ANJOS SOUZA, ANA BEATRIZ; DOS PASSOS, AMANDA STEPHANE CRUZ; MARTINI, MATHEUS CAVALHEIRO; BARBOSA, PRISCILLA PASCHOAL; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; et al. SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner. NATURE COMMUNICATIONS, v. 13, n. 1, p. 15-pg., . (20/08716-9, 20/04558-0, 19/05155-9, 21/10373-5, 13/07607-8, 20/04919-2, 20/04746-0, 17/01184-9, 17/23920-9, 16/24163-4, 16/00194-8, 18/21635-8, 19/00098-7, 20/05040-4, 17/08264-8, 20/04579-7, 19/26119-0, 19/04726-2, 20/04583-4, 20/15959-5)

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