Advanced search
Start date

Modeling mosaicism in focal cortical dysplasia using cortical organoids


Focal Cortical Dysplasia (FCD) represents the most prevalent cause of severe drug-resistant epilepsy in children. Despite the considerable progress in FCD diagnosis and surgical therapy, treatment of these patients remains a challenge. Our goal is to establish a human in vitro model of FCD using cortical organoids to recapitulate brain somatic mosaicism in FCD and to have a reliable model, mimicking as much as possible the background genetic finding in the FCD patients, to screen novel anti-epileptic drugs. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: