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Mortality due to congenital syphilis in the State of São Paulo

Grant number: 19/03799-6
Support type:Research Grants - Research in Public Policies
Duration: September 01, 2019 - August 31, 2021
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Cooperation agreement: CNPq - PPSUS
Principal researcher:Carla Gianna Luppi
Grantee:Carla Gianna Luppi
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers: Adriana Sanudo ; Angela Tayra ; Beatriz da Costa Thome ; Carlos Roberto Veiga Kiffer ; Carmen Silvia Bruniera Domingues ; Daniela Testoni ; Daniela Vinhas Bertolini ; Giselle Garcia Origo ; maria aparecida da silva ; Mariana Cabral Schveitzer ; Mariza Vono Tancredi ; Marli de Fátima Prado ; Rita de Cássia Xavier Balda ; Roberto José Carvalho da Silva ; Valdir Monteiro Pinto
Associated scholarship(s):20/11370-7 - Congenital syphilis mortality in the State of São Paulo, BP.TT
19/27081-7 - Congenital syphilis mortality in the State of São Paulo, BP.TT
19/26372-8 - Congenital syphilis mortality in the State of São Paulo, BP.TT


Congenital syphilis (SC) constitutes an important public health problem due to its magnitude, transcendence and the existence of effective prevention and control measures. Between 2009 and 2016, there was a 4.7-fold increase in the incidence rate of SC (TISC) in the state of São Paulo (ESP), in 2016 3,801 cases of SC were reported, corresponding to a TISC of 6.3 cases per 1,000 live births (NV). This increase in the number of cases was accompanied by an increase in the occurrence of unfavorable outcomes of SC: abortion, stillbirth or death; in 2016 10% of the cases presented this unfavorable evolution. The objective of this study will be to investigate the unfavorable outcomes, death, stillbirth and abortion, by SC occurring in the state of São Paulo, between 2007 and 2018. Methods: the study universe will be the data for all cases reported in the ESP of SC from 2007 to 2018. Secondary data from the Sinan Disease Information System, the Mortality Information System (SIM) and the syphilis vertical transmission investigation protocol will be analyzed. The research will be conducted in three stages: database organization, historical series analysis with aggregated data; and analysis of factors associated with congenital syphilis with individual data. Expected results: The analysis and discussion of these results will allow the development of public policies to reduce the number of unfavorable outcomes related to congenital syphilis. (AU)

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