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UK:Brazil Joint Centre Partnership in Leishmaniasis (JCPiL)

Grant number: 18/14398-0
Support type:Research Projects - Thematic Grants
Duration: September 01, 2019 - August 31, 2023
Field of knowledge:Biological Sciences - Parasitology
Cooperation agreement: MRC, UKRI ; Newton Fund, with FAPESP as a partner institution in Brazil
Principal researcher:Angela Kaysel Cruz
Grantee:Angela Kaysel Cruz
Principal researcher abroad: Jeremy Mottram
Institution abroad: University of York, England
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Dario Simões Zamboni ; Hiro Goto ; Luiz Ricardo Orsini Tosi
Assoc. researchers:José Angelo Lauletta Lindoso ; Mírian Nacagami Sotto
Associated scholarship(s):21/10043-5 - Comparative computational analyses of transcriptomes and large-scale identification of interactions between RNA-binding proteins and ncRNAs and repair/recombination proteins and DNA, BP.TT
20/14059-0 - Protein RuvB-like 1: the biological relevance of putative arginine methylation in Leishmania braziliensis, BP.IC
20/01883-7 - Does signalling during DNA replication stress drive genome diversity in Leishmania?, BP.PD
 + associated scholarships 20/00087-2 - Functional validation of potential non-coding RNAs differentially expressed during Leishmania viannia braziliensis life cycle, BP.PD
20/02372-6 - Actions coordinated by the enzyme Arginine Methyltransferase 5 of Leishmania braziliensis, BP.PD
20/00088-9 - Epigenetic regulation of Leishmania gene expression, BP.PD
20/01323-1 - Evaluation of the role of inflammasomes in Leishmania infantum infection of mice, BP.TT
19/26621-8 - Evaluation of the role of inflammasomas and their signaling pathways in murine experimental infection by Leishmania infantum, BP.PD
19/25393-1 - UK:Brazil Joint Centre Partnership in Leishmaniasis (JCPiL). work plan 1 molecular pathology of leishmaniasis: towards host-directed therapy in leishmaniases, BP.PD
19/18607-5 - Computational identification and structural characterization of non-coding RNA in Leishmania braziliensis, BP.PD - associated scholarships

Abstract

Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited available treatments are repurposed from other applications, have severe side effects; including anaphylaxis, growing drug resistances and are inappropriate for the primarily juvenile leishmaniasis patients. Disease pathologies range from tegumental (mucocutaneous and cutaneous leishmaniasis) to visceral and cases in Brazil alone range from 20,000 TL to 3,500 VL per annum.The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL) will fund five inter-related projects and 3 workshops to promote research at the interface of basic and clinical science, to extend existing collaborations between UK and Brazil and to develop new partnerships and interdisciplinary ways of working. Travel will be used to cross train PIs, PDRAs and PhD students in the foremost technologies and expertise available worldwide. Studies will be focused on understanding parasite genetic diversity in the context of variations of Leishmania infectivity and virulence factor expression, mechanisms of immune evasion, diversity of host response, resultant immunopathology and sustained activation that drives chronic disease. We will investigate novel molecular targets of vulnerable pathways that are essential to Leishmania viability, optimise techniques and diagnostic markers to predict and definitively categorize patient pathology profiles to inform more bespoke, effective treatment design. Our JCPiL will create new collaborations in order to build sustainable, fundable future projects and make an impact on this deadly disease. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
An agenda for forgotten diseases 
Articles published in Agência FAPESP Newsletter about the research grant:
TITULO 
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, GABRIEL L. A.; TOSI, LUIZ R. O.; MCCULLOCH, RICHARD; BLACK, JENNIFER ANN. Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, AUG 6 2021. Web of Science Citations: 0.
CAMPAGNARO, GUSTAVO D.; NAY, EDWARD; PLEVIN, MICHAEL J.; CRUZ, ANGELA K.; WALRAD, PEGINE B. Arginine Methyltransferases as Regulators of RNA-Binding Protein Activities in Pathogenic Kinetoplastids. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 8, JUN 11 2021. Web of Science Citations: 0.
SOUZA, MARINA DE ASSIS; RAMOS-SANCHEZ, EDUARDO MILTON; MUXEL, SANDRA MARCIA; LAGOS, DIMITRIS; REIS, LUIZA CAMPOS; PEREIRA, VALERIA REGO ALVES; BRITO, MARIA EDILEUZA FELINTO; ZAMPIERI, RICARDO ANDRADE; KAYE, PAUL MARTIN; FLOETER-WINTER, LUCILE MARIA; GOTO, HIRO. miR-548d-3p Alters Parasite Growth and Inflammation in Leishmania (Viannia) braziliensis Infection. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, JUN 10 2021. Web of Science Citations: 0.
COSTA-SILVA, HELLIDA MARINA; RESENDE, BRUNO CARVALHO; UMAKI, ADRIANA CASTILHOS SOUZA; PRADO, WILLIAN; DA SILVA, MARCELO SANTOS; VIRGILIO, STELA; MACEDO, ANDREA MARA; PENA, SERGIO DANILO JUNHO; TAHARA, ERICH BIRELLI; TOSI, LUIZ RICARDO ORSINI; ELIAS, MARIA CAROLINA; ANDRADE, LUCIANA OLIVEIRA; REIS-CUNHA, JOAO LUIS; FRANCO, GLORIA REGINA; FRAGOSO, STENIO PERDIGAO; MACHADO, CARLOS RENATO. DNA Topoisomerase 3 alpha Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, MAY 13 2021. Web of Science Citations: 0.
REIS, LUIZA C.; RAMOS-SANCHEZ, EDUARDO MILTON; ARAUJO, FERNANDA N.; LEAL, ARIANE F.; OZAKI, CHRISTIANE Y.; SEVILLANO, ORLANDO R.; USCATA, BERNARDINA A.; GOTO, HIRO. Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2021, MAY 5 2021. Web of Science Citations: 1.
MENDES-AGUIAR, CAROLINA; LOPES-SIQUEIRA, CAMILLA; PETTITO-ASSIS, FABRICIO; PEREIRA-OLIVEIRA, MARCIA; DE OLIVEIRA-NETO, MANOEL PAES; PIRMEZ, CLAUDE; DA-CRUZ, ALDA MARIA; GOTO, HIRO. Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2021, MAR 30 2021. Web of Science Citations: 0.
DE CARVALHO, RENAN V. H.; LIMA-JUNIOR, DJALMA S.; DE OLIVEIRA, V, CAROLINE; ZAMBONI, DARIO S. Endosymbiotic RNA virus inhibits Leishmania-induced caspase-11 activation. ISCIENCE, v. 24, n. 1 JAN 22 2021. Web of Science Citations: 0.
OLIVIER, MARTIN; ZAMBONI, DARIO S. Leishmania Viannia guyanensis, LRV1 virus and extracellular vesicles: a dangerous trio influencing the faith of immune response during muco-cutaneous leishmaniasis. CURRENT OPINION IN IMMUNOLOGY, v. 66, n. SI, p. 108-113, OCT 2020. Web of Science Citations: 1.
ANDRADE, WARRISON A.; ZAMBONI, DARIO S. NLRC4 biology in immunity and inflammation. Journal of Leukocyte Biology, JUN 2020. Web of Science Citations: 0.
DE CARVALHO, RENAN V. H.; ZAMBONI, DARIO S. Inflammasome Activation in Response to Intracellular Protozoan Parasites. Trends in Parasitology, v. 36, n. 5, p. 459-472, MAY 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.