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Membrane photodamage by new lipophilic lumazine derivatives

Grant number: 19/12957-4
Support Opportunities:Research Grants - Visiting Researcher Grant - International
Duration: September 09, 2019 - October 21, 2019
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal Investigator:Rosangela Itri
Grantee:Rosangela Itri
Visiting researcher: Mariana Vignoni
Visiting researcher institution: Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Argentina
Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Considering the previous studies on pterin derivatives, carried out as a cooperation project between the Argentinean and Brazilian groups, this project is aimed to expand the study of lipophilic type I photosensitizers to new compounds derived from lumazine. In this way, the alkyllumazines, recently synthesized by the Argentinean group, will be here investigated according to the following particular objectives:*To study the fluorescence properties of the lumazine derivatives when they are intercalated in lipid biomembranes, investigating their possible use as fluorescent probes.*To investigate the generation of singlet oxygen after UVA irradiation of lumazine derivatives intercalated in biomembranes, helping to elucidate the mechanism of action of this new class of photosensitizers.*To explore the effects of photosensitized lipid peroxidation by lipophilic lumazine derivatives in model membranes, using different lipids as substrates and comparing efficiencies with pterin derivatives. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIGNONI, ALEJANDRO; LAYANA, CARLA; JUNQUEIRA, HELENA C.; THOMAS, ANDRES H.; ITRI, ROSANGELA; BAPTISTA, MAURICIO S.; VIGNONI, MARIANA. Alkylation of a hydrophilic photosensitizer enhances the contact-dependent photo-induced oxidation of phospholipid membranes. DYES AND PIGMENTS, v. 187, . (19/12957-4, 16/04296-0, 13/07937-8, 12/50680-5)

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