Advanced search
Start date

Membrane photodamage by new lipophilic lumazine derivatives

Grant number: 19/12957-4
Support type:Research Grants - Visiting Researcher Grant - International
Duration: September 09, 2019 - October 21, 2019
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal researcher:Rosangela Itri
Grantee:Rosangela Itri
Visiting researcher: Mariana Vignoni
Visiting researcher institution: Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Argentina
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Considering the previous studies on pterin derivatives, carried out as a cooperation project between the Argentinean and Brazilian groups, this project is aimed to expand the study of lipophilic type I photosensitizers to new compounds derived from lumazine. In this way, the alkyllumazines, recently synthesized by the Argentinean group, will be here investigated according to the following particular objectives:*To study the fluorescence properties of the lumazine derivatives when they are intercalated in lipid biomembranes, investigating their possible use as fluorescent probes.*To investigate the generation of singlet oxygen after UVA irradiation of lumazine derivatives intercalated in biomembranes, helping to elucidate the mechanism of action of this new class of photosensitizers.*To explore the effects of photosensitized lipid peroxidation by lipophilic lumazine derivatives in model membranes, using different lipids as substrates and comparing efficiencies with pterin derivatives. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items