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Evaluation of biomarkers of renal damage and inflammatory profile in elderly diabetic rats

Abstract

Diabetes mellitus type II (type II DM) is a multifactorial disease, which affects about 8.8 percent of the world's population. Its prevalence is greater in elderly individuals, since the aging promotes decrease of physiological and cellular functions. DM is characterized by persistent hyperglycemia when uncontrolled progresses to micro and macrovascular changes followed by peripheral arterial disease and chronic kidney disease (CKD). The growth of the elderly population in the world is of the utmost importance to the evaluation of the role of aging in the installation of CKD in diabetics and assess the potential of new predictive biomarkers. In this context, this project aims study candidates for early molecular markers of CKD (FGF-23, PTX-3, CD147, TNFR, MCT1 e MCT4) and associate the expression of these genes with the dosages of serum markers of renal injury patterns. It will be use the experimental model of DM induced by aloxane in Wistar rats. The animals shall be divided into: young diabetic rats (JDM), diabetic elderly (DMI), sham control young (CSJ) and sham control elderly (CSI) and samples will be collected after 30 days of confirmation of DM installation. We will use blood and urine samples to perform biochemical analyses (blood glucose, urea, creatinine, ApoA, ApoB and HbGlic; as well as microalbuminuria, creatinine and proteinuria, respectively). In addition, we will evaluate the expression of genes involved in glucose metabolism, angiogenesis and fibrosis: FGF-23, PTX-3, TNFR, MCT1, MCT4 and CD147, in blood and urine samples and in kidney tissue. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VEIGA, GLAUCIA; ALVES, BEATRIZ; PEREZ, MATHEUS; ALCANTARA, LUIZ VINICIUS; RAIMUNDO, JOYCE; ZAMBRANO, LYSIEN; ENCINA, JESSICA; PEREIRA, EDIMAR CRISTIANO; BACCI, MARCELO; MURAD, NEIF; et al. NGAL and SMAD1 gene expression in the early detection of diabetic nephropathy by liquid biopsy. Journal of Clinical Pathology, v. 73, n. 11, p. 713-721, . (18/24808-0)
ENCINAS, JESSICA FREITAS ARAUJO; PEIRO, CARLOS HENRIQUE FONCESCA; PEREZ, MATHEUS MOREIRA; RAIMUNDO, JOYCE REGINA SANTOS; DE GOIS, KATHARYNA CARDOSO; PERES, MARINA CRISTINA; DRAGHI, PATRICIA FERRANTE; ARCIA, CATHERINE GIOVANNA COSTAS; SIMOES, DIOGO PIMENTA; MURAD, NEIF; et al. Does nebivolol have renoprotective action in patients with chronic kidney disease conditions? An integrative review. European Journal of Pharmacology, v. 905, . (18/24808-0)

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