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Post-translational modifications in Chagas Disease biological processes and diagnostics: novel methodological approaches and biological applications

Grant number: 18/15549-1
Support Opportunities:Research Grants - Young Investigators Grants - Phase 2
Duration: October 01, 2019 - September 30, 2025
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Giuseppe Palmisano
Grantee:Giuseppe Palmisano
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Cláudio Romero Farias Marinho ; Maria Julia Manso Alves
Associated research grant:14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications, AP.JP
Associated grant(s):20/04923-0 - SARS-CoV-2 glycosylation: a blueprint structural insight for understanding COVID-19 pathogenesis, AP.R
19/08796-5 - Novel nanoemulsion for enhanced efficacy and better safety of benznidazole in the treatment of Chagas Disease, AP.R SPRINT
Associated scholarship(s):24/03969-7 - Development of analytical techniques in proteomics and glycoproteomics applied to Trypanosoma cruzi study., BP.TT
23/04937-9 - Technical development in proteomics: strategies and analytical techniques, BP.TT
22/09915-0 - Modulation of host N-glycosylation machinery during Trypanosoma cruzi infection, BP.DR
+ associated scholarships 22/00796-9 - Unravelling the biological role of T. cruzi protein glycosylation, BP.PD
21/14179-9 - The role of the endoplasmic reticulum in viral and parasitic virulence, BP.DD
21/14751-4 - Novel mass spectrometry-based technologies for post-translational modifications analysis, BP.PD
21/00140-3 - Development and optimization of enrichment methods for arginylated proteins in complex biological matrices, BP.DR - associated scholarships

Abstract

Chagas Disease, caused by the protozoan parasite T. cruzi, is a neglected disease, which can lead to Cardiomyopathy, neurological complications and megaviscera. Over 100 years after its description, this disease affects 8 million people and most of them do not know that they are infected. Although endemic in the South America, it has been recognized a worldwide public health problem due to global population migration. Despite the great efforts to control T. cruzi transmission and introduce novel therapeutic options, one of the unmet needs is the development of novel sensitive and specific diagnostic markers for treatment response and disease progression. Moreover, a better understanding of the T. cruzi-host interaction will aid in prioritize novel therapeutic targets. This project is divided in three parts: 1) analytical method development for post-translational modifications (PTMs); 2) elucidation of the role of protein glycosylation and arginylation in the T. cruzi-host interaction and 3) biomarker discovery for Chagas Disease. The development of novel analytical methods for PTMs analysis will offer the possibility to detect protein modifications in complex biological systems with high accuracy and sensitivity. In particular, the identification of protein glycosylation of different T. cruzi strains belonging to the seven DTUs will be evaluated and associated to the expression of specific glycosyltransferases. The large-scale analysis of the cell surface glycoproteome and glycome combined with functional assays will be used as a molecular determinant to link the T. cruzi glycosylation enzymes expression and phenotype. The characterization of protein arginylation in T. cruzi and the Tc-Ate1 enzyme involved in this process will allow us to understand the role of this poorly explored PTM in Chagas Disease biology. The third part of the project will be focused on implementing a diagnostic platform for urinary protein biomarker discovery in Chagas Disease. (AU)

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Scientific publications (42)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAWAHARA, REBECA; CHERNYKH, ANASTASIA; ALAGESAN, KATHIRVEL; BERN, MARSHALL; CAO, WEIQIAN; CHALKLEY, ROBERT J.; CHENG, KAI; CHOO, MATTHEW S.; EDWARDS, NATHAN; GOLDMAN, RADOSLAV; et al. Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. NATURE METHODS, v. 18, n. 11, p. 1304+, . (18/15549-1)
GAVINHO, BRUNO; SABATKE, BRUNA; FEIJOLI, VERONICA; ROSSI, IZADORA VOLPATO; DA SILVA, JANAINA MACEDO; EVANS-OSSES, INGRID; PALMISANO, GIUSEPPE; LANGE, SIGRUN; RAMIREZ, MARCEL IVAN. Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles FromGiardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, . (18/15549-1, 18/18257-1, 14/06863-3)
ROSA-FERNANDES, LIVIA; BARBOSA, RAQUEL HORA; DOS SANTOS, MARIA LUIZA B.; ANGELI, CLAUDIA B.; SILVA, THIAGO P.; MELO, ROSSANA C. N.; DE OLIVEIRA, GILBERTO SANTOS; LEMOS, BERNARDO; VAN EYK, JENNIFER E.; LARSEN, MARTIN R.; et al. Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome. JOURNAL OF PROTEOME RESEARCH, v. 19, n. 11, p. 4496-4515, . (18/15549-1, 18/18257-1, 14/06863-3)
RODRIGUES, MARIANE A. D.; PIMENTA, MARCELA V.; COSTA, IRIS M.; ZENATTI, PRISCILA P.; MIGITA, NATACHA A.; YUNES, JOSE A.; RANGEL-YAGUI, CARLOTA O.; DE SA, MATHEUS M.; PESSOA, ADALBERTO; COSTA-SILVA, TALES A.; et al. Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase. Biochemical Pharmacology, v. 182, . (14/06863-3, 18/18257-1, 13/08617-7, 16/25896-5, 15/07749-2, 18/15104-0, 13/08139-8, 18/15549-1)
SOUZA JUNIOR, DOUGLAS RICARDO; MARTINS SILVA, AMANDA RIBEIRO; ROSA-FERNANDES, LIVIA; REIS, LORENNA ROCHA; ALEXANDRIA, GABRIELLY; BHOSALE, SANTOSH D.; GHILARDI, FABIO DE ROSE; DALCOQUIO, TALIA FALCAO; BERTOLIN, ADRIADNE JUSTI; NICOLAU, JOSE CARLOS; et al. HDL proteome remodeling associates with COVID-19 severity. JOURNAL OF CLINICAL LIPIDOLOGY, v. 15, n. 6, p. 796-804, . (15/26722-8, 16/00696-3, 20/04923-0, 19/25702-4, 17/07725-1, 18/15549-1, 18/18257-1, 13/07937-8)
MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA F.; ROSA-FERNANDES, LIVIA; MARINHO, CLAUDIO R. F.; PALMISANO, GIUSEPPE. Protein glycosylation in extracellular vesicles: Structural characterization and biological functions. Molecular Immunology, v. 135, p. 226-246, . (18/15549-1, 18/20468-0, 18/18257-1, 20/04923-0)
MONTEIRO JUNIOR, JULIO CESAR; KRUGER, ARNE; PALMISANO, GIUSEPPE; WRENGER, CARSTEN. Transporter-Mediated Solutes Uptake as Drug Target in Plasmodium falciparum. FRONTIERS IN PHARMACOLOGY, v. 13, p. 8-pg., . (15/26722-8, 18/15549-1, 18/18257-1, 18/08820-0, 20/04923-0)
LIMA, GUILHERME MEIRA; EFFER, BRIAN; BIASOTO, HENRIQUE PELLIN; FEIJOLI, VERONICA; PESSOA, ADALBERTO; PALMISANO, GIUSEPPE; MONTEIRO, GISELE. Glycosylation of L-asparaginase from E. coli through yeast expression and site-directed mutagenesis. Biochemical Engineering Journal, v. 156, . (15/07749-2, 13/08617-7, 14/06863-3, 18/18257-1, 18/15549-1, 16/15787-4)
MULE, SIMON NGAO; COSTA-MARTINS, ANDRE GUILHERME; ROSA-FERNANDES, LIVIA; DE OLIVEIRA, GILBERTO SANTOS; RODRIGUES, CARLA MONADELI F.; QUINA, DANIEL; ROSEIN, GRAZIELLA E.; GERALDES TEIXEIRA, MARTA MARIA; PALMISANO, GIUSEPPE. PhyloQuant approach provides insights into Trypanosoma cruzi evolution using a systems-wide mass spectrometry-based quantitative protein profile. COMMUNICATIONS BIOLOGY, v. 4, n. 1, . (18/13283-4, 17/04032-5, 14/06863-3, 18/15549-1, 18/18257-1, 14/25494-9)
MULE, S. N.; MANCHOLA, N. C.; DE OLIVEIRA, G. S.; PEREIRA, M.; MAGALHAES, R. D. M.; TEIXEIRA, A. A.; COLLI, W.; ALVES, M. J. M.; PALMISANO, G.. Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix. JOURNAL OF PROTEOMICS, v. 231, . (14/25494-9, 14/10046-0, 18/03727-2, 17/04032-5, 18/18257-1, 18/13283-4, 18/15549-1, 12/03887-3)
GOMES, LAURA CORDEIRO; SANSON, MARINA CORDEIRO GOMES; BRAININ, PHILIP; DE MELO, MARIA DA CONCEICAO VIEIRA; DE SOUZA, RODRIGO MEDEIROS; MAZARO, JANAINA; LIMA, KARINE OLIVEIRA; RESENDE, JUNIA SILVA; VIEIRA, ISABELLE VICTORIA MARTINS; MESQUITA, EDINILSON DA SILVA; et al. Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon. PLoS One, v. 16, n. 7, . (18/20468-0, 18/18257-1, 18/15549-1, 15/26722-8, 14/06863-3)
CARRASCO, ALEXIS GERMAN MURILLO; OTAKE, ANDREIA HANADA; MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA FEIJOLI; PALMISANO, GIUSEPPE; ANDRADE, LUCIANA NOGUEIRA DE SOUSA; CHAMMAS, ROGER. Deciphering the Functional Status of Breast Cancers through the Analysis of Their Extracellular Vesicles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 16, p. 33-pg., . (18/15549-1, 18/18257-1, 20/04923-0, 21/00140-3, 19/05583-0)
SAN FRANCISCO, JUAN; ASTUDILLO, CONSTANZA; LUIS VEGA, JOSE; CATALAN, ALEJANDRO; GUTIERREZ, BESSY; ARAYA, JORGE E.; ZAILBERGER, ANIBAL; MARINA, ANABEL; GARCIA, CARLOS; SANCHEZ, NURIA; et al. Trypanosoma cruzi pathogenicity involves virulence factor expression and upregulation of bioenergetic and biosynthetic pathways. VIRULENCE, v. 13, n. 1, p. 22-pg., . (18/15549-1, 20/04923-0, 18/18257-1, 21/00140-3)
MACEDO-DA-SILVA, JANAINA; MARINHO, CLAUDIO ROMERO FARIAS; PALMISANO, GIUSEPPE; ROSA-FERNANDES, LIVIA. Lights and Shadows of TORCH Infection Proteomics. GENES, v. 11, n. 8, p. 31-pg., . (14/06863-3, 18/20468-0, 18/18257-1, 18/15549-1)
MACEDO-DA-SILVA, JANAINA; ROSA-FERNANDES, LIVIA; GOMES, VINICIUS DE MORAIS; SANTIAGO, VERONICA FEIJOLI; SANTOS, DEIVID MARTINS; MOLNAR, CATARINA MARIA STANISCHESK; BARBOZA, BRUNO RAFAEL; DE SOUZA, EDMARCIA ELISA; MARQUES, RODOLFO FERREIRA; BOSCARDIN, SILVIA BEATRIZ; et al. Protein Arginylation Is Regulated during SARS-CoV-2 Infection. Viruses-Basel, v. 15, n. 2, p. 25-pg., . (18/15549-1, 18/18257-1, 20/06409-1, 22/09915-0, 20/02988-7, 21/00140-3, 20/12277-0, 21/14179-9, 15/26722-8)
LAZARI, LUCAS C.; ZERBINATI, RODRIGO M.; ROSA-FERNANDES, LIVIA; SANTIAGO, VERONICA FEIJOLI; ROSA, KLAISE F.; ANGELI, CLAUDIA B.; SCHWAB, GABRIELA; PALMIERI, MICHELLE; SARMENTO, DMITY J. S.; MARINHO, CLAUDIO R. F.; et al. ALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-1. OURNAL OF ORAL MICROBIOLOG, v. 14, n. 1, . (18/15549-1, 20/06409-1, 20/04923-0, 18/18257-1, 15/26722-8, 17/03966-4, 21/07490-0, 18/20468-0)
KAWAHARA, REBECA; RECUERO, SAULO; NOGUEIRA, FABIO C. S.; DOMONT, GILBERTO B.; LEITE, KATIA R. M.; SROUGI, MIGUEL; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia. PROTEOMICS, v. 19, n. 21-22, p. 12-pg., . (17/03010-8, 18/18257-1, 18/15549-1, 14/06863-3, 15/02866-0)
CHATTERJEE, SAYANTANI; LEE, LING Y.; KAWAHARA, REBECA; ABRAHAMS, JODIE L.; ADAMCZYK, BARBARA; ANUGRAHAM, MERRINA; ASHWOOD, CHRISTOPHER; SUMER-BAYRAKTAR, ZEYNEP; BRIGGS, MATTHEW T.; CHIK, JENNY H. L.; et al. Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers. PROTEOMICS, v. 19, n. 21-22, p. 13-pg., . (18/15549-1, 17/03010-8, 14/06863-3, 15/02866-0)
SANTIAGO, VERONICA FEIJOLI; DOMBROWSKI, JAMILLE GREGORIO; KAWAHARA, REBECA; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; MURILLO, OSCAR; SANTANA, THAIS VIGGIANI; PACCINI COUTINHO, JOAO VICTOR; MACEDO-DA-SILVA, JANAINA; LAZARI, LUCAS CARDOSO; et al. Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy. GENES, v. 14, n. 8, p. 20-pg., . (21/14751-4, 18/15549-1, 20/06747-4, 20/04923-0, 17/04032-5, 21/00140-3, 19/12068-5, 18/20468-0)
KAWAHARA, REBECA; RECUERO, SAULO; NOGUEIRA, FABIO C. S.; DOMONT, GILBERTO B.; LEITE, KATIA R. M.; SROUGI, MIGUEL; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia. PROTEOMICS, v. 19, n. 21-22, SI, . (18/15549-1, 15/02866-0, 18/18257-1, 17/03010-8, 14/06863-3)
MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; et al. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7, . (13/07467-1, 16/04000-3, 17/17943-6, 15/19530-5, 14/06863-3, 18/15549-1, 13/07937-8)
LATROFA, MARIA STEFANIA; PALMISANO, GIUSEPPE; ANNOSCIA, GIADA; PIERRI, CIRO LEONARDO; CHANDRASHEKAR, RAMASWAMY; OTRANTO, DOMENICO. Major antigen and paramyosin proteins as candidate biomarkers for serodiagnosis of canine infection by zoonotic Onchocerca lupi. PLoS Neglected Tropical Diseases, v. 15, n. 2, . (17/04032-5, 18/18257-1, 14/06863-3, 18/15549-1)
MISERANI MAGALHAES, RUBENS DANIEL; MATTOS, ELICIANE CEVOLANI; ROZANSKI, ANDREI; FAVORETTO GALANTE, PEDRO ALEXANDRE; PALMISANO, GIUSEPPE; CRUZ, ANGELA KAYSEL; COLLI, WALTER; CAMARGO, ANAMARIA ARANHA; MANSO ALVES, MARIA JULIA. Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix. PLoS Neglected Tropical Diseases, v. 14, n. 5, . (14/10046-0, 13/16002-2, 18/15549-1, 18/18257-1, 14/25494-9, 14/06863-3)
MARTINS, LARISSA ALMEIDA; PALMISANO, GIUSEPPE; CORTEZ, MAURO; KAWAHARA, REBECA; DE FREITAS BALANCO, JOSE MARIO; FUJITA, ANDRE; ALONSO, BEATRIZ IGLESIAS; BARROS-BATTESTI, DARCI MORAES; BRAZ, GLORIA REGINA CARDOSO; TIRLONI, LUCAS; et al. The intracellular bacterium Rickettsia rickettsii exerts an inhibitory effect on the apoptosis of tick cells. PARASITES & VECTORS, v. 13, n. 1, . (12/24105-3, 18/15549-1, 18/18257-1, 14/11513-1, 14/06863-3, 14/05855-7, 13/26450-2)
CARNEIRO, ANDREIA; MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA FEIJOLI; DE OLIVEIRA, GILBERTO SANTOS; GUIMARAES, THIAGO; MENDONCA, CLARISSA FEROLLA; DE OLIVEIRA BRANQUINHO, JESSICA LAIS; LUCENA, CINTIA VERDAN; OSORIO, JULIANA; PERNAMBUCO, EDUARDO; et al. Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training. JOURNAL OF PROTEOMICS, v. 258, p. 17-pg., . (18/13283-4, 14/27198-8, 18/18257-1, 20/04923-0, 18/15549-1, 21/00140-3)
CAVALCANTE, TAINA; MEDEIROS, MARIANA MEDINA; MULE, SIMON NGAO; PALMISANO, GIUSEPPE; STOLF, BEATRIZ SIMONSEN. The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (17/04032-5, 18/18257-1, 18/15549-1, 18/14972-8)
KAWAHARA, REBECA; RECUERO, SAULO; SROUGI, MIGUEL; LEITE, KATIA R. M.; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. MOLECULAR & CELLULAR PROTEOMICS, v. 20, . (14/06863-3, 15/02866-0, 17/03010-8, 18/15549-1, 18/18257-1)
SUMAM DE OLIVEIRA, DAFFINY; KRONENBERGER, THALES; PALMISANO, GIUSEPPE; WRENGER, CARSTEN; DE SOUZA, EDMARCIA ELISA. Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (18/10150-3, 20/04923-0, 19/26771-0, 20/12277-0, 17/03966-4, 18/18257-1, 18/15549-1, 15/26722-8)
DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, . (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 20/06747-4, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)
LAZARI, LUCAS CARDOSO; GHILARDI, FABIO DE ROSE; ROSA-FERNANDES, LIVIA; ASSIS, DIEGO M.; NICOLAU, JOSE CARLOS; SANTIAGO, VERONICA FEIJOLI; DALCOQUIO, TALIA FALCAO; ANGELI, CLAUDIA B.; BERTOLIN, ADRIADNE JUSTI; MARINHO, CLAUDIO R. F.; et al. Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19. LIFE SCIENCE ALLIANCE, v. 4, n. 8, . (20/04705-2, 18/15549-1, 17/03966-4, 15/26722-8, 18/20468-0, 20/04923-0, 18/18257-1)
COUTINHO, JOAO V. P.; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; DE OLIVEIRA, GILBERTO SANTOS; MANCHOLA, NUBIA CAROLINA; SANTIAGO, VERONICA FEIJOLI; COLLI, WALTER; WRENGER, CARSTEN; MANSO ALVES, MARIA JULIA; PALMISANO, GIUSEPPE. The thermal proteome stability profile of Trypanosoma cruzi in epimastigote and trypomastigote life stages. JOURNAL OF PROTEOMICS, v. 248, . (18/13283-4, 18/15549-1, 14/06863-3, 17/03966-4, 15/26722-8, 17/19854-0, 17/04032-5, 18/18257-1)
MULE, SIMON NGAO; ROSA-FERNANDES, LIVIA; COUTINHO, JOAO V. P.; GOMES, VINICIUS DE MORAIS; MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA FEIJOLI; QUINA, DANIEL; DE OLIVEIRA, GILBERTO SANTOS; THAYSEN-ANDERSEN, MORTEN; LARSEN, MARTIN R.; et al. Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay. JOURNAL OF PROTEOMICS, v. 248, . (18/15549-1, 13/07937-8, 20/04923-0, 17/04032-5, 18/18257-1)
MULE, SIMON NGAO; SAAD, JOYCE SILVA; FERNANDES, LIVIA ROSA; STOLF, BEATRIZ S.; CORTEZ, MAURO; PALMISANO, GIUSEPPE. Protein glycosylation inLeishmaniaspp.. MOLECULAR OMICS, v. 16, n. 5, p. 407-424, . (20/04923-0, 18/15549-1, 16/23689-2, 17/04032-5)
CAPELLI-PEIXOTO, JANAINA; MULE, SIMON NGAO; TANO, FABIA TOMIE; PALMISANO, GIUSEPPE; STOLF, BEATRIZ SIMONSEN. Proteomics and Leishmaniasis: Potential Clinical Applications. PROTEOMICS CLINICAL APPLICATIONS, v. 13, n. 6, . (17/26197-6, 17/04287-3, 14/26777-4, 14/06863-3, 18/18257-1, 18/15549-1, 17/04032-5)
CHATTERJEE, SAYANTANI; LEE, LING Y.; KAWAHARA, REBECA; ABRAHAMS, JODIE L.; ADAMCZYK, BARBARA; ANUGRAHAM, MERRINA; ASHWOOD, CHRISTOPHER; SUMER-BAYRAKTAR, ZEYNEP; BRIGGS, MATTHEW T.; CHIK, JENNY H. L.; et al. Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers. PROTEOMICS, v. 19, n. 21-22, SI, . (17/03010-8, 18/15549-1, 15/02866-0, 14/06863-3)
KISCHKEL, BRENDA; BONICHE-ALFARO, CAMILA; MENEZES, ISABELA DE GODOY; ROSSI, SUELEN ANDREIA; ANGELI, CLAUDIA BLANES; DE ALMEIDA, SANDRO ROGERIO; PALMISANO, GIUSEPPE; LOPES-BEZERRA, LEILA; NOSANCHUK, JOSHUA D.; TABORDA, CARLOS PELLESCHI. Immunoproteomic and Immunopeptidomic Analyses of Histoplasma capsulatum Reveal Promiscuous and Conserved Epitopes Among Fungi With Vaccine Potential. FRONTIERS IN IMMUNOLOGY, v. 12, . (18/18257-1, 16/08730-6, 14/06863-3, 17/25780-0, 18/26402-1, 18/15549-1)
MULE, SIMON NGAO; GOMES, VINICIUS DE MORAIS; WAILEMANN, ROSANGELA A. M.; MACEDO-DA-SILVA, JANAINA; ROSA-FERNANDES, LIVIA; LARSEN, MARTIN R.; LABRIOLA, LETICIA; PALMISANO, GIUSEPPE. HSPB1 influences mitochondrial respiration in ER-stressed beta cells. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 9, . (17/04032-5, 14/02745-6, 17/03618-6, 18/18257-1, 16/04676-7, 20/04923-0, 16/14845-0, 13/07937-8, 18/15549-1, 21/00507-4)
CARNEIRO, ANDREIA; VIANA-GOMES, DIEGO; MACEDO-DA-SILVA, JANAINA; OLIVEIRA LIMA, GISCARD HUMBERTO; MITRI, SIMONE; ALVES, SERGIO RABELLO; KOLLIARI-TURNER, ALEXANDER; ZANOTELI, EDMAR; DE AQUINO NETO, FRANCISCO RADLER; PALMISANO, GIUSEPPE; et al. Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis. Neuromuscular Disorders, v. 31, n. 7, p. 583-595, . (20/04923-0, 18/15549-1, 18/18257-1)
RIBEIRO, GIOVANE DE JESUS GOMES; YAN, SUN LIU REI; PALMISANO, GIUSEPPE; WRENGER, CARSTEN. Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022. PHARMACEUTICS, v. 15, n. 6, p. 19-pg., . (18/15549-1, 18/18257-1, 20/04923-0, 17/26358-0, 15/26722-8)
TANO, FABIA TOMIE; BARBOSA, GUSTAVO ROLIM; DE REZENDE, ELOIZA; OLIVEIRA SOUZA, RODOLPHO ORNITZ; MUXEL, SANDRA MARCIA; SILBER, ARIEL MARIANO; PALMISANO, GIUSEPPE; STOLF, BEATRIZ SIMONSEN. Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains. PLoS One, v. 17, n. 8, p. 26-pg., . (18/15549-1, 18/18257-1, 18/14972-8, 17/26197-6, 14/06863-3)
FLOREZ-ALVAREZ, LIZDANY; DE SOUZA, EDMARCIA ELISA; BOTOSSO, VIVIANE FONGARO; LEAL DE OLIVEIRA, DANIELLE BRUNA; HO, PAULO LEE; TABORDA, CARLOS PELLESCHI; PALMISANO, GIUSEPPE; CAPURRO, MARGARETH LARA; REBELLO PINHO, JOAO RENATO; FERREIRA, HELENA LAGE; et al. Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential. FRONTIERS IN MICROBIOLOGY, v. 13, p. 16-pg., . (16/20045-7, 19/12303-4, 18/18257-1, 20/04923-0, 17/03966-4, 17/27131-9, 22/01812-8, 18/15549-1, 15/26722-8, 20/12277-0, 20/06409-1, 16/08730-6)
MATTOS, ELICIANE CEVOLANI; PALMISANO, GIUSEPPE; GOLDMAN, GUSTAVO H.. Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin. MSPHERE, v. 5, n. 3, p. 16-pg., . (18/15549-1, 18/18257-1, 17/19288-5, 16/07870-9, 14/06863-3)

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